Abstract
Follow-up colonoscopy of a 25-year-old Japanese man with ulcerative colitis (UC) who had undergone endoscopic mucosal resection twice for early colon cancers revealed the presence of a new 1.5-cm-diameter tumor in the sigmoid colon. It was diagnosed by preoperative biopsy as a poorly differentiated adenocarcinoma. Sigmoidectomy was performed, and the pathological findings revealed lymphoepithelioma-like carcinoma (LEC). In situ hybridization to detect Epstein-Barr virus (EBV)-encoded small RNAs showed positive signals in stromal lymphocytes, but weak signals in the tumor cells. The association between EBV and LEC was obscure in this case. Unlike typical UC-mediated colon cancers, the lesion was poorly differentiated, and negative for p53 signals immunohistochemically. These findings may hint at a novel mechanism of carcinogenesis in UC-mediated colorectal cancer.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M Vilor Y Tsutsumi (1995) ArticleTitleLocalization of Epstein-Barr virus genome in lymphoid cells in poorly differentiated adenocarcinoma with lymphoid stroma of the colon Pathol Int 45 695–7 Occurrence Handle8548044 Occurrence Handle1:STN:280:DyaK287hslCjsw%3D%3D Occurrence Handle10.1111/j.1440-1827.1995.tb03524.x
H Matsunou F Konishi H Hori T Ikeda K Sasaki Y Hirose et al. (1996) ArticleTitleCharacteristics of Epstein-Barr virus-associated gastric carcinoma with lymphoid stroma in Japan Cancer 77 1998–2004 Occurrence Handle8640662 Occurrence Handle10.1002/(SICI)1097-0142(19960515)77:10<1998::AID-CNCR6>3.0.CO;2-D Occurrence Handle1:STN:280:DyaK283gs1Sitg%3D%3D
JC Iezzoni MJ Gaffey LM Weiss (1995) ArticleTitleThe role of Epstein-Barr virus in lymphoepithelioma-like carcinomas Am J Clin Pathol 103 308–15 Occurrence Handle7872253 Occurrence Handle1:STN:280:DyaK2M7nslSqsQ%3D%3D
S Kon K Kasai N Tsuzuki M Nishibe T Kitagawa T Nishibe et al. (2001) ArticleTitleLymphoepithelioma-like carcinoma of rectum: possible relation with EBV Pathol Res Pract 197 577–82 Occurrence Handle11518052 Occurrence Handle10.1078/0344-0338-00130 Occurrence Handle1:STN:280:DC%2BD3MvnsVyqtQ%3D%3D
M Tokunaga CE Land Y Uemura T Tokudome S Tanaka E Sato (1993) ArticleTitleEpstein Barr virus in gastric carcinoma Am J Pathol 143 1250–4 Occurrence Handle8238241 Occurrence Handle1:STN:280:DyaK2c%2Fls1Kntw%3D%3D
L Zhou Y Miyagi H Enomoto Y Tanaka I Aoki M Tsukada (1998) ArticleTitleEvaluation of Epstein-Barr virus infection in hypopharyngeal carcinomas from 37 Japanese patients Mod Pathol 11 509–12 Occurrence Handle9647586 Occurrence Handle1:STN:280:DyaK1czgvFyjsw%3D%3D
L Nacopoulou P Azaris N Papacharalampous P Davaris (1981) ArticleTitlePrognostic significance of histologic host response in cancer of the large intestine Cancer 47 930–6 Occurrence Handle7226044 Occurrence Handle10.1002/1097-0142(19810301)47:5<930::AID-CNCR2820470519>3.0.CO;2-1 Occurrence Handle1:STN:280:DyaL3M7osF2gtA%3D%3D
JP Palazzp KR Mittal (1996) ArticleTitleLymphoepithelioma-like carcinoma of the rectum in a patient with ulcerative colitis Am J Gastroenterol 91 398–9
S Fujii T Fujimori T Chiba (2003) ArticleTitleUsefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia J Exp Clin Cancer Res 22 107–15 Occurrence Handle12725330 Occurrence Handle1:CAS:528:DC%2BD3sXjt1yqsL4%3D
M Bruwer KW Schmid N Senninger G Schurmann (2002) ArticleTitleImmunohistochemical expression of P53 and oncogenes in ulcerative colitis-associated colorectal carcinoma World J Surg 26 390–6 Occurrence Handle11865380 Occurrence Handle10.1007/s00268-001-0237-7
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kojima, Y., Mogaki, M., Takagawa, R. et al. A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis. J Gastroenterol 42, 181–185 (2007). https://doi.org/10.1007/s00535-006-1981-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00535-006-1981-0