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Proteomics in acute kidney injury—current status and future promise

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Abstract

Pediatric acute kidney injury (AKI) is associated with increased morbidity, mortality and associated healthcare costs. Unfortunately, there are currently no effective therapies available, and this has been attributed in part to the late diagnosis of AKI. Therefore, significant efforts have been made to develop early diagnostic tools for AKI in the hope that early identification of renal injury will allow for effective therapeutic intervention. Different transcriptomic, proteomic and metabolomic technologies offer unbiased approaches to identifying novel biomarkers of AKI. This review will provide an overview of non-invasive pediatric AKI biomarkers. It will focus on unbiased technologies by using examples of biomarkers identified with “-omic” technologies and different methodological and implementation challenges will be highlighted. Finally, emerging proteomic techniques that may be applicable to biomarker discovery will be presented. Ultimately, the development of novel biomarkers of AKI may lead to the early diagnosis and effective therapeutic intervention of AKI to improve patient outcomes.

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Acknowledgments

Dr. Ho is funded by the Canadian Institutes of Health Research, The Kidney Foundation of Canada and the KRESCENT New Investigator Program.

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Authors and Affiliations

  1. Section of Nephrology, Department Internal Medicine, University of Manitoba, Winnipeg, MB, Canada

    Julie Ho & Claudio Rigatto

  2. Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, MB, Canada

    Julie Ho

  3. Section of Nephrology, Department Paediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada

    Allison Dart

  4. Sections of Nephrology & Biomedical Proteomics, Health Sciences Centre, GE421C, 820 Sherbrook Street, Winnipeg, MB, R3A 1R9, Canada

    Julie Ho

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  1. Julie Ho
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Correspondence to Julie Ho.

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Ho, J., Dart, A. & Rigatto, C. Proteomics in acute kidney injury—current status and future promise. Pediatr Nephrol 29, 163–171 (2014). https://doi.org/10.1007/s00467-013-2415-x

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  • DOI: https://doi.org/10.1007/s00467-013-2415-x

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