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Intensive hemodialysis for cardiomyopathy associated with end-stage renal disease

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Abstract

Heart and kidney dysfunction often coexist, and increasing evidence supports the interaction of these two organs, as demonstrated by the clinical condition known as cardiorenal syndrome (CRS). We report a pediatric patient with end-stage renal disease (ESRD) who developed a dilated cardiomyopathy and decompensated heart failure after undergoing unilateral nephrectomy and while on maintenance peritoneal dialysis. He showed marked improvement in his cardiac function with the addition of intensive hemodialysis. We discuss the pathophysiology of cardiorenal syndrome in patients with ESRD and suggest that intensive dialysis may be an effective therapy for this condition.

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References

  1. Ronco C, House AA, Haapio M (2008) Cardiorenal syndrome: refining the definition of a complex symbiosis gone wrong. Intensive Care Med 34:957–962

    Article  Google Scholar 

  2. Berl T, Henrich W (2006) Kidney-heart interactions: epidemiology, pathogenesis, and treatment. Clin J Am Soc Nephrol 1:8–18

    Article  CAS  Google Scholar 

  3. Meyer TW, Hostetter TH (2007) Uremia. N Engl J Med 357:1316–1325

    Article  CAS  Google Scholar 

  4. Parekh RS, Carroll CE, Wolfe RA, Port FK (2002) Cardiovascular mortality in children and young adults with end-stage kidney disease. J Pediatr 141:191–197

    Article  CAS  Google Scholar 

  5. Mitsnefes MM, Daniels SR, Schwartz SM, Khoury P, Strife CF (2001) Changes in left ventricular mass in children and adolescents during chronic dialysis. Pediatr Nephrol 16:318–323

    Article  CAS  Google Scholar 

  6. Foley RN, Parfrey PS, Harnett JD, Kent GM, Martin CJ, Murray DC, Barre PE (1995) Clinical and echocardiographic disease in patients starting end-stage renal disease therapy. Kidney Int 47:186–192

    Article  CAS  Google Scholar 

  7. Aoki J, Ikari Y, Nakajima H, Mori M, Sugimoto T, Hatori M, Tanimoto S, Amiya E, Hara K (2005) Clinical and pathologic characteristics of dilated cardiomyopathy in hemodialysis patients. Kidney Int 67:333–340

    Article  Google Scholar 

  8. Weisensee D, Low-Friedrich I, Riehle M, Bereiter-Hahn J, Schoeppe W (1993) In vitro approach to ‘uremic cardiomyopathy’. Nephron 65:392–400

    Article  CAS  Google Scholar 

  9. Konings CJ, Kooman JP, Schonck M, Dammers R, Cheriex E, Palmans Meulemans AP, Hoeks AP, van Kreel B, Gladziwa U, van der Sande FM, Leunissen KM (2002) Fluid status, blood pressure, and cardiovascular abnormalities in patients on peritoneal dialysis. Perit Dial Int 22:477–487

    PubMed  Google Scholar 

  10. Matteucci MC, Wuhl E, Picca S, Mastrostefano A, Rinelli G, Romano C, Rizzoni G, Mehls O, de Simone G, Schaefer F (2006) Left ventricular geometry in children with mild to moderate chronic renal insufficiency. J Am Soc Nephrol 17:218–226

    Article  Google Scholar 

  11. Abdel-Aty H, Boye P, Zagrosek A, Wassmuth R, Kumar A, Messroghli D, Bock P, Dietz R, Friedrich MG, Schulz-Menger J (2005) Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches. J Am Coll Cardiol 45:1815–1822

    Article  Google Scholar 

  12. Nixon JV, Mitchell JH, McPhaul JJ Jr, Henrich WL (1983) Effect of hemodialysis on left ventricular function. Dissociation of changes in filling volume and in contractile state. J Clin Invest 71:377–384

    Article  CAS  Google Scholar 

  13. Hung J, Harris PJ, Uren RF, Tiller DJ, Kelly DT (1980) Uremic cardiomyopathy—effect of hemodialysis on left ventricular function in end-stage renal failure. N Engl J Med 302:547–551

    Article  CAS  Google Scholar 

  14. Chan C, Floras JS, Miller JA, Pierratos A (2002) Improvement in ejection fraction by nocturnal haemodialysis in end-stage renal failure patients with coexisting heart failure. Nephrol Dial Transplant 17:1518–1521

    Article  Google Scholar 

  15. Hayashi SY, Brodin LA, Alvestrand A, Lind B, Stenvinkel P, Mazza do Nascimento M, Qureshi AR, Saha S, Lindholm B, Seeberger A (2004) Improvement of cardiac function after haemodialysis. Quantitative evaluation by colour tissue velocity imaging. Nephrol Dial Transplant 19:1497–1506

    Article  Google Scholar 

  16. Zolty R, Hynes PJ, Vittorio TJ (2008) Severe left ventricular systolic dysfunction may reverse with renal transplantation: uremic cardiomyopathy and cardiorenal syndrome. Am J Transplant 8:2219–2224

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, ML 7022, Cincinnati, OH, 45229, USA

    Edward Nehus, Jens Goebel, Mark Mitsnefes & Benjamin Laskin

  2. Division of Cardiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Angela Lorts

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  1. Edward Nehus
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  2. Jens Goebel
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  3. Mark Mitsnefes
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  4. Angela Lorts
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  5. Benjamin Laskin
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Correspondence to Edward Nehus.

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Nehus, E., Goebel, J., Mitsnefes, M. et al. Intensive hemodialysis for cardiomyopathy associated with end-stage renal disease. Pediatr Nephrol 26, 1909–1912 (2011). https://doi.org/10.1007/s00467-011-1921-y

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  • DOI: https://doi.org/10.1007/s00467-011-1921-y

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