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Preoperative infliximab treatment and postoperative complications after laparoscopic restorative proctocolectomy with ileal pouch–anal anastomosis: a case-matched study

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Abstract

Background

Infliximab offers promising new therapeutic options for treatment of moderate to severe ulcerative colitis. However, several studies suggest that it increases postoperative complication rates for patients who later require a restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA). This study aimed to assess the postoperative course of patients after laparoscopic IPAA, comparing those who had and those who had not received infliximab before surgery.

Methods

The authors identified patients from their institution’s IPAA database, finding 13 patients who had received preoperative infliximab treatment. Using age, gender, and type of procedure (2 or 3 stages) as criteria, they matched these cases with infliximab-naive patients drawn from the same database. The differences in perioperative data between the two groups were analyzed. Complications and their severity were assessed using the Strasberg classification.

Results

No significant difference was found between patients treated with and those treated without infliximab for each variable studied, namely, mean operative time (353 vs. 355 min), complication rate (23 vs. 38%), and mean hospital stay (22 vs. 25 days).

Conclusion

The study findings showed no adverse impact from previous infliximab therapy on the laparoscopic IPAA postoperative course.

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Disclosures

Benjamin Coquet-Reinier, Stéphane V. Berdah, Jean-Charles Grimaud, David Birnbaum, Pierre-Alain Cougard, Marc Barthet, Ariadne Desjeux Vincent Moutardier, and Christian Brunet have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of Digestive Diseases Surgery, Hôpital Nord, Chemin des Bourrellys, 13915, Marseille Cedex 20, France

    Benjamin Coquet-Reinier, Stéphane V. Berdah, Jean-Charles Grimaud, David Birnbaum, Pierre-Alain Cougard, Marc Barthet, Ariadne Desjeux, Vincent Moutardier & Christian Brunet

  2. Université de la Méditerranée, 13007, Marseille, France

    Stéphane V. Berdah

Authors
  1. Benjamin Coquet-Reinier
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  2. Stéphane V. Berdah
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  3. Jean-Charles Grimaud
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  4. David Birnbaum
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  5. Pierre-Alain Cougard
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  6. Marc Barthet
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  7. Ariadne Desjeux
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  8. Vincent Moutardier
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  9. Christian Brunet
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Corresponding author

Correspondence to Stéphane V. Berdah.

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Coquet-Reinier, B., Berdah, S.V., Grimaud, JC. et al. Preoperative infliximab treatment and postoperative complications after laparoscopic restorative proctocolectomy with ileal pouch–anal anastomosis: a case-matched study. Surg Endosc 24, 1866–1871 (2010). https://doi.org/10.1007/s00464-009-0861-0

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  • DOI: https://doi.org/10.1007/s00464-009-0861-0

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