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Familial prostate cancer and HOXB13 founder mutations: geographic and racial/ethnic variations

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References

  • Akbari MR, Trachtenberg J, Lee J, Tam S, Bristow R, Loblaw A, Narod SA, Nam RK (2012) Association between germline HOXB13 G84E mutation and risk of prostate cancer. J Natl Cancer Inst 104: 1260–1262

    Google Scholar 

  • Choi M, Scholl UI, Ji W, Tikhonova IR, Zumbo P, Nayir A, Bakkaloglu A, Özen S, Sanjad S, Nelson-Williams C, Farhi A, Mane S (2009) Genetic diagnosis by whole exome capture and massively parallel DNA sequencing. Proc Natl Acad Sci USA 106:19096–19101

    Article  PubMed  CAS  Google Scholar 

  • Cooper DN, Krawczak M, Antonorakis SE (1995) The nature and mechanisms of human gene mutation. In: Scriver C, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease, 7th edn. McGraw-Hill, New York, pp 259–291

    Google Scholar 

  • Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y, Bizon C, Yan G, Gielzak M, Partin AW, Shanmugam V, Izatt T, Sinari S, Craig DW, Zheng L, Walsh PC, Montie JE, Xu J, Carpten JD, Isaacs WB, Cooney KA (2012) Germline mutations in HOXB13 and prostate-cancer risk. N Engl J Med 366:141–149

    Article  PubMed  CAS  Google Scholar 

  • Gao X, Zacharek A, Grignon DJ, Sakr W, Powell IJ, Porter AT, Honn KV (1995) Localization of potential tumor suppressor loci to a <2 Mb region on chromosome 17q in human prostate cancer. Oncogene 11:1241–1247

    PubMed  CAS  Google Scholar 

  • Gillanders EM, Xu J, Chang B-L, Lange EM, Wiklund F, Bailey-Wilson JE, Baffoe-Bonnie A, Jones M, Gildea D, Riedesel E, Albertus J, Isaacs SD, Wiley KE, Mohai CE, Matikainen MP, Tammela TLJ, Zheng SL, Brown WM, Rökman A, Carpten JD, Meyers DA, Walsh PC, Schleutker J, Gronberg H, Cooney KA, Isaacs WB, Trent JM (2004) Combined genome-wide scan for prostate cancer susceptibility genes. J Natl Cancer Inst 96:1240–1247

    Article  PubMed  CAS  Google Scholar 

  • Gnirke A, Melnikov A, Maguire J, Rogov P, LeProust EM, Brockman W, Fennell T, Giannoukos G, Fisher S, Russ C, Gabriel S, Jaffe DB, Lander ES, Nusbaum C (2009) Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nat Biotechnol 27:182–189

    Article  PubMed  CAS  Google Scholar 

  • Hellebrand H, Sutter C, Honisch E, Gross E, Wappenschmidt B, Schem C, Deissler H, Ditsch N, Gress V, Kiechle M, Bartram CR, Schmutzler RK, Niederacher D, Arnold N, Meindl A (2011) Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer. Hum Mutat 32:E2176–E2188

    Article  PubMed  CAS  Google Scholar 

  • Karlsson R, Aly M, Clements M, Zheng L, Adolfsson J, Xu J, Grönberg H, Wiklund F (2012) A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk. Eur Urol. doi: 10.1016/j.eururo.2012.07.027

  • Lange EM, Gillanders EM, Davis CC, Brown WM, Campbell JK, Jones M, Gildea D, Riedesel E, Albertus J, Freas-Lutz D, Markey C, Giri V, Dimmer JB, Montie JE, Trent JM, Cooney KA (2003) Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan Prostate Cancer Genetics Project finds evidence for linkage on chromosome 17 near BRCA1. Prostate 57:326–334

    Article  PubMed  CAS  Google Scholar 

  • Lange EM, Robbins CM, Gillanders EM, Zheng SL, Xu J, Wang Y, White KA, Chang B-L, Ho LA, Trent JM, Carpten JD, Isaacs WB, Cooney KA (2007) Fine-mapping the putative chromosome 17q21-22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis. Hum Genet 121:49–55

    Article  PubMed  CAS  Google Scholar 

  • Lin X, Qu L, Chen Z, Xu C, Ye D, Shao Q, Wang X, Qi J, Chen Z, Zhou F, Wang M, Wang Z, He D, Wu D, Gao X, Yuan J, Wang G, Xu Y, Wang G, Dong P, Jiao Y, Yang J, Ou-Yang J, Jiang H, Zhu Y, Turner AR, Tao S, Na R, Ding Q, Lu D, Shi R, Sun J, Liu F, Zheng SL, Mo Z, Sun Y, Xu J (2012) A novel germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men. Prostate. doi: 10.1002/pros.22552

  • Maher B (2009) Exome-sequencing takes centre stage in cancer profiling. Nature 459:146–147

    Article  PubMed  Google Scholar 

  • Ng SB, Turner EH, Robertson PD, Flygare SD, Bigham AW, Lee C, Shaffer T, Wong M, Bhattacharjee A, Eichler EE, Bamshad M et al (2009) Targeted capture and massively parallel sequencing of 12 human exomes. Nature 461:272–276

    Article  PubMed  CAS  Google Scholar 

  • Thompson ER, Boyle SE, Johnson J, Ryland GL, Sawyer S, Choong DY, kConFab, Chenevix-Trench G, Trainer AH, Lindeman GJ, Mitchell G, James PA, Campbell IG (2012) Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. Hum Mutat 33:95–99

    Article  PubMed  CAS  Google Scholar 

  • Williams BJ, Jones E, Zhu XL, Steele MR, Stephenson RA, Rohr LR, Brothman AR (1996) Evidence for a tumor suppressor gene distal to BRCA1 in prostate cancer. J Urol 155:720–725

    Article  PubMed  CAS  Google Scholar 

  • Xu J, Lange E, Lu L, Zheng S, Zhong W, Thibodeau S, Cannon-Albright L, Camp N, Ray A, Stanford JL, Wiley K, Isaacs S, Walsh P, Naier C, Vogel W, Schleutker J, Luedeke M, Wahlfors T, Tammela T, Schaid D, McDonnell S, DeRycke M, Cancel-Tassin G, Cussenot O, Wiklund F, Gronberg H, Eeles R, Easton D, Kote-Jarai Z, Whittemore A, Hsieh C-L, Giles G, Hopper J, Gianluca S, Catalona W, Mandal D, Ledet E, Foulkes W, Hamel N, Maehle L, Moller P, Isaac P, Bailey-Wilson J, Carpten JD, Seminara D, Cooney K (2012) HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). Hum Genet. doi:10.1007/s00439-012-1229-4

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  1. Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, Omaha, NE, 68178, USA

    Henry T. Lynch & Trudy G. Shaw

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  1. Henry T. Lynch
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  2. Trudy G. Shaw
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Correspondence to Henry T. Lynch.

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Invited editorial on Xu et al. (2012).

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Lynch, H.T., Shaw, T.G. Familial prostate cancer and HOXB13 founder mutations: geographic and racial/ethnic variations. Hum Genet 132, 1–4 (2013). https://doi.org/10.1007/s00439-012-1226-7

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