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Markers that discriminate between European and African ancestry show limited variation within Africa

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Abstract.

Markers informative for ancestry are necessary for admixture mapping and improving case-control association analyses. In particular, African Americans are an admixed population for which genetic studies require accurately evaluating admixture. This will require markers that can be used in African Americans to determine if a given genomic region is of European or African ancestry. This report shows that, despite studies indicating high intra-African sequence variation, markers with large inter-ethnic differences have only small variations in allele distribution among divergent African populations and should be valuable for evaluating admixture in complex disease genetic studies.

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Authors and Affiliations

  1. Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616-8669, USA, , , , ,

    Heather E. Collins-Schramm, Darwin J. Operario & Michael F. Seldin

  2. National Human Genome Center at Howard University, 2041 Georgia Ave., Rm. 615, Washington, DC 20060, USA, , , , ,

    Rick A. Kittles

  3. Center for Medical Genetics, Marshfield Medical Research Foundation, Marshfield, WI 54449, USA, , , , ,

    James L. Weber

  4. Rosalind Russell Medical Research Center for Arthritis, University of California, San Franciso, San Francisco, CA 94143, USA, , , , ,

    Lindsey A. Criswell

  5. Preventive Medicine and Epidemiology, Loyola University, Maywood, IL 60153, USA, , , , ,

    Richard S. Cooper

Authors
  1. Heather E. Collins-Schramm
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  2. Rick A. Kittles
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  3. Darwin J. Operario
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  4. James L. Weber
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  5. Lindsey A. Criswell
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  6. Richard S. Cooper
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  7. Michael F. Seldin
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Collins-Schramm, H.E., Kittles, R.A., Operario, D.J. et al. Markers that discriminate between European and African ancestry show limited variation within Africa. Hum Genet 111, 566–569 (2002). https://doi.org/10.1007/s00439-002-0818-z

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  • DOI: https://doi.org/10.1007/s00439-002-0818-z

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