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Ultrastructural alterations induced by nifurtimox and another nitro derivative on epimastigotes of Trypanosoma cruzi

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Abstract.

We report the ultrastructural alterations induced on epimastigotes by nifurtimox and 5-nitro-2-thienyl-malononitrile (5NO2TM), a novel compound with anti-Trypanosoma cruzi activity. Parasites treated with concentrations of nifurtimox lower than usually employed for this kind of study showed vacuolisation, alterations of the mitochondria, the nucleus and the ribosomes. 5NO2TM caused the same kind of damage, but to a greater degree. This result correlates with the fact that cultures treated with this compound experienced a greater loss of viability.

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Authors and Affiliations

  1. Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain, Spain

    S. Muelas-Serrano & A. Gómez-Barrio

  2. Instituto de Química Médica, Consejo Superior de Investigaciones Científicas, C/Juan de la Cierva 3, 28003 Madrid, Spain, Spain

    V. Arán

  3. Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Alcalá, 28871 Alcalá de Henares, Spain, Spain

    J. Pérez-Serrano & F. Rodríguez-Caabeiro

Authors
  1. S. Muelas-Serrano
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  2. J. Pérez-Serrano
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  3. A. Gómez-Barrio
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  4. V. Arán
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  5. F. Rodríguez-Caabeiro
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Muelas-Serrano, S., Pérez-Serrano, J., Gómez-Barrio, A. et al. Ultrastructural alterations induced by nifurtimox and another nitro derivative on epimastigotes of Trypanosoma cruzi . Parasitol Res 88, 97–101 (2002). https://doi.org/10.1007/s004360100497

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  • DOI: https://doi.org/10.1007/s004360100497

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