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Management of stage I cervical sarcoma botryoides in childhood and adolescence

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Abstract

Rhabdomyosarcomas are the most common soft tissue sarcomas in childhood. The botryoid variant arises in infancy from the vagina or urinary bladder and extremely rarely from the uterine cervix. Treatment regimes range from local excision of the tumour to radical hysterectomy with adjuvant multidrug therapy and/or radiotherapy. In cases of minimal cervical invasion, the less invasive local excision in combination with adjuvant chemotherapy has resulted in excellent survival rates with complete functional preservation of the bladder, rectum, vagina, and ovaries. We present here a 30-year literature review and a case report of a cervical sarcoma botryoides in a 5-year-old girl. Conclusion:based on the literature review and our own observation, we recommend minor surgical approaches in combination with chemotherapy as the treatment of choice for early stage I cervical rhabdomyosarcoma.

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Abbreviations

IRS :

Intergroup Rhabdomyosarcoma Study Group

RMS :

rhabdomyosarcoma

VAC :

vincristine, adriamycin, cyclophosphamide

VAI :

vincristine, adriamycin, ifosfamide

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Justus-Liebig-University Giessen, Klinikstrasse 32, 35392 , Giessen, Germany

    Susanne E. M. Gruessner & Hans R. Tinneberg

  2. Department of Biochemistry, University of Nairobi, Nairobi, Kenya

    Charles O. A. Omwandho

  3. Institute of Pathology, Justus-Liebig-University, Giessen, Germany

    Thomas Dreyer & Rainer M. Bohle

  4. Department of Paediatric Oncology, Justus-Liebig-University, Giessen, Germany

    Renate Blütters-Sawatzki & Alfred Reiter

Authors
  1. Susanne E. M. Gruessner
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  2. Charles O. A. Omwandho
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  3. Thomas Dreyer
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  4. Renate Blütters-Sawatzki
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  5. Alfred Reiter
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  6. Hans R. Tinneberg
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  7. Rainer M. Bohle
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Correspondence to Susanne E. M. Gruessner.

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Gruessner, S.E.M., Omwandho, C.O.A., Dreyer, T. et al. Management of stage I cervical sarcoma botryoides in childhood and adolescence. Eur J Pediatr 163, 452–456 (2004). https://doi.org/10.1007/s00431-004-1469-y

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  • DOI: https://doi.org/10.1007/s00431-004-1469-y

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