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Inhibition of HBV infection by bovine lactoferrin and iron-, zinc-saturated lactoferrin

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Abstract

In this study, we investigated the effect of bovine lactoferrin (BLf), lactoferrin hydrolysate, or iron-, zinc-saturated lactoferrin on hepatitis B virus (HBV)-infected HepG2 cells. Fluorescent quantitative polymerase chain reaction (FQ-PCR) was used to quantify HBV-DNA copies. BLf, iron- or zinc-saturated lactoferrin significantly inhibited the amplification of HBV-DNA in a dose-dependent manner in HBV-infected HepG2 cells. However, the inhibitive effect of lactoferrin hydrolysate on HBV-DNA copies was insignificant. These findings suggest that BLf inhibits the function of HBV by integrated structure. In conclusion, BLf, iron- or zinc-saturated BLf is one of the candidates for anti-HBV reagents in treatment of patients with hepatitis.

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Acknowledgment

This research was supported by grant from Heilongjiang Education Department (No. 1055G004 Research project).

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Authors and Affiliations

  1. Key Laboratory of Dairy Science, Ministry of Education; College of Food Science, Northeast Agricultural University, 150030, Harbin, Heilongjiang, China

    Songtao Li, Haibo Zhou & Ning Liu

  2. Staff Room of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, 150086, Harbin, Heilongjiang, China

    Songtao Li

  3. Staff Room of Epidemiology, College of Public Health, Harbin Medical University, 150086, Harbin, Heilongjiang, China

    Haibo Zhou & Guirong Huang

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  1. Songtao Li
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  2. Haibo Zhou
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  4. Ning Liu
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Correspondence to Ning Liu.

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Li, S., Zhou, H., Huang, G. et al. Inhibition of HBV infection by bovine lactoferrin and iron-, zinc-saturated lactoferrin. Med Microbiol Immunol 198, 19–25 (2009). https://doi.org/10.1007/s00430-008-0100-7

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  • DOI: https://doi.org/10.1007/s00430-008-0100-7

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