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Molecular pathology of well-differentiated thyroid carcinomas

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Abstract

The newly discovered molecular features of well-differentiated thyroid carcinomas derived from follicular cells are reviewed, within the frame of the 2004 WHO classification of thyroid tumours, under the following headings: “Follicular carcinoma”, “Papillary carcinoma”, “Follicular variant of papillary carcinoma” and “Hürthle cell tumours”. A particular emphasis is put on the meaning of PAX8–PPARγ rearrangements, RAS and BRAF mutations, and deletions and mutations of mitochondrial genes and of nuclear genes encoding for mitochondrial enzymes, for thyroid tumorigenesis.

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Acknowledgements

We are grateful to Fundação para a Ciência e Tecnologia for grant support to Ana Preto, Ana Sofia Rocha, Patrícia Castro and Valdemar Máximo. This study was supported by Fundação para a Ciência e Tecnologia POCTI/FEDER (POCTI/NSE/48171/2002).

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Authors and Affiliations

  1. Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), R. Roberto Frias s/n, 4200, Porto, Portugal

    Manuel Sobrinho-Simões, Ana Preto, Ana Sofia Rocha, Patrícia Castro, Valdemar Máximo, Elsa Fonseca & Paula Soares

  2. Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal

    Manuel Sobrinho-Simões, Patrícia Castro, Elsa Fonseca & Paula Soares

  3. Department of Pathology, University Hospital of S. João, Porto, Portugal

    Manuel Sobrinho-Simões & Elsa Fonseca

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  1. Manuel Sobrinho-Simões
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  2. Ana Preto
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  3. Ana Sofia Rocha
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Correspondence to Manuel Sobrinho-Simões.

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Sobrinho-Simões, M., Preto, A., Rocha, A.S. et al. Molecular pathology of well-differentiated thyroid carcinomas. Virchows Arch 447, 787–793 (2005). https://doi.org/10.1007/s00428-005-0065-5

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