Skip to main content

Advertisement

SpringerLink
Log in

The plasmacytoid monocyte/interferon producing cells

  • Review Article
  • Published:
Virchows Archiv Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  1. Aderem A, Ulevitch RJ (2000) Toll-like receptors in the induction of the innate immune response. Nature 406:782–787

    CAS  PubMed  Google Scholar 

  2. Asselin-Paturel C, Boonstra A, Dalod M, Durand I, Yessaad N, Dezutter-Dambuyant C, Vicari A, O’Garra A, Biron C, Briere F, Trinchieri G (2001) Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol 2:1144–1150

    Article  CAS  PubMed  Google Scholar 

  3. Baddoura FK, Hanson C,Chan WC (1992) Plasmacytoid monocyte proliferation associated with myeloproliferative disorders. Cancer 69:1457–1467

    CAS  PubMed  Google Scholar 

  4. Barron MA, Blyveis N, Palmer BE, MaWhinney S, Wilson CC (2003) Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals. J Infect Dis 187:26–37

    Article  PubMed  Google Scholar 

  5. Bauer M, Redecke V, Ellwart JW, Scherer B, Kremer JP, Wagner H, Lipford GB (2001) Bacterial cpg-DNA triggers activation and maturation of human cd11c(−), cd123(+) dendritic cells. J Immunol 166:5000–5007

    CAS  PubMed  Google Scholar 

  6. Beiske K, Langholm R, Godal T, Marton PF (1986) T-zone lymphoma with predominance of ‘plasmacytoid T-cells’ associated with myelomonocytic leukaemia—a distinct clinicopathological entity. J Pathol 150:247–255

    CAS  PubMed  Google Scholar 

  7. Bendriss-Vermare N, Barthelemy C, Durand I, Bruand C, Dezutter-Dambuyant C, Moulian N, Berrih-Aknin S, Caux C, Trinchieri G, Briere F (2001) Human thymus contains IFN-alpha-producing CD11c(−), myeloid CD11c(+), and mature interdigitating dendritic cells. J Clin Invest 107:835–844

    CAS  PubMed  Google Scholar 

  8. Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J, Pascual V (2003) Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 197:711–723

    Article  CAS  PubMed  Google Scholar 

  9. Bjorck P (2001) Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. Blood 98:3520–3526

    Article  CAS  PubMed  Google Scholar 

  10. Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J (2001) Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 294:1540–1543

    Article  CAS  PubMed  Google Scholar 

  11. Blom B, Ho S, Antonenko S, Liu YJ (2000) Generation of interferon alpha-producing predendritic cell (Pre-DC)2 from human CD34(+) hematopoietic stem cells. J Exp Med 192:1785–1796

    Article  CAS  PubMed  Google Scholar 

  12. Burg S, Rissoan M-C, Brindon J-M, Dhuen T, D’Agostini M, Bendriss-Vermare N, Brière F (2002) Role of granzyme B in human plasmacytoid dendritic cells (abstract). In: Seventh International Symposium on Dendritic Cells 52:P45

  13. Caux C, Vanbervliet B, Massacrier C, Dezutter-Dambuyant C, de Saint-Vis B, Jacquet C, Yoneda K, Imamura S, Schmitt D, Banchereau J (1996) CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J Exp Med 184:695–706

    CAS  PubMed  Google Scholar 

  14. Cederblad B, Blomberg S, Vallin H, Perers A, Alm GV, Ronnblom L (1998) Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon-alpha- producing cells. J Autoimmun 11:465–470

    Article  CAS  PubMed  Google Scholar 

  15. Cella M, Sallusto F,Lanzavecchia A (1997) Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 9:10–16

    CAS  PubMed  Google Scholar 

  16. Cella M, Jarrossay D, Facchetti F, Alebardi O, Nakajima H, Lanzavecchia A, Colonna M (1999) Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 5:919–923

    Article  CAS  PubMed  Google Scholar 

  17. Cella M, Facchetti F, Lanzavecchia A, Colonna M (2000) Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent Th1 polarization. Nat Immunol 1:305–310

    Article  CAS  PubMed  Google Scholar 

  18. Chaperot L, Bendriss N, Manches O, Gressin R, Maynadie M, Trimoreau F, Orfeuvre H, Corront B, Feuillard J, Sotto JJ, Bensa JC, Briere F, Plumas J, Jacob MC (2001) Identification of a leukemic counterpart of the plasmacytoid dendritic cells. Blood 97:3210–3217

    Article  CAS  PubMed  Google Scholar 

  19. Chen YH, Lan JL (1998) Kikuchi disease in systemic lupus erythematosus: clinical features and literature review. J Microbiol Immunol Infect 31:187–192

    CAS  PubMed  Google Scholar 

  20. Colonna M, Krug A, Cella M (2002) Interferon-producing cells: on the front line in immune responses against pathogens. Curr Opin Immunol 14:373–379

    Article  CAS  PubMed  Google Scholar 

  21. Comeau MR, Van der Vuurst de Vries AR, Maliszewski CR, Galibert L (2002) CD123 bright plasmacytoid predendritic cells: progenitors undergoing cell fate conversion? J Immunol 169:75–83

    CAS  PubMed  Google Scholar 

  22. Dalod M, Salazar-Mather TP, Malmgaard L, Lewis C, Asselin-Paturel C, Briere F, Trinchieri G, Biron CA (2002) Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo. J Exp Med 195:517–528

    Article  CAS  PubMed  Google Scholar 

  23. Danon AD, Krishnan J, Frizzera G (1993) Morpho-immunophenotypic diversity of Castleman’s disease, hyaline-vascular type: with emphasis on a stroma-rich variant and a new pathogenetic hypothesis. Virchows Arch A Pathol Anat Histopathol 423:369–382

    CAS  PubMed  Google Scholar 

  24. Dominguez DC, Torres ML, Antony S (2003) Is human herpesvirus 6 linked to kikuchi-fujimoto disease? The importance of consistent molecular and serologic analysis. South Med J 96:226–233

    PubMed  Google Scholar 

  25. Donaghy H, Pozniak A, Gazzard B, Qazi N, Gilmour J, Gotch F, Patterson S (2001) Loss of blood CD11c(+) myeloid and CD11c(−) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood 98:2574–2576

    Article  CAS  PubMed  Google Scholar 

  26. Dumoulin FL, Leifeld L, Sauerbruch T, Spengler U (1999) Autoimmunity induced by interferon-alpha therapy for chronic viral hepatitis. Biomed Pharmacother 53:242–254

    Article  CAS  PubMed  Google Scholar 

  27. Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, Buck DW, Schmitz J (2000) BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol 165:6037–6046

    CAS  PubMed  Google Scholar 

  28. Dzionek A, Sohma J, Nagafune M, Cella M, Colonna M, Facchetti F, Gunther G, Johnston I, Lanzavecchia A, Nagasaka T, Okada T, Vermi W, Winkels G, Yamamoto T, Zysk M, Yamaguchi Y, Schmitz J (2001) BDCA-2, a novel plasmacytoid dendritic cell cell-specific type II C-type lectin, mediates antigen-capture and is a potent inhibitor of interferon-alpha/beta induction. J Exp Med 194:1823–1834

    Article  CAS  PubMed  Google Scholar 

  29. Dzionek A, Inagaki Y, Okawa K, Nagafune J, Rock JJ, Sohma Y, Winkels G, Zysk M, Yamaguchi Y, Schmitz JJ (2002) Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions (1). Hum Immunol 63:1133–1148

    Article  CAS  PubMed  Google Scholar 

  30. Eckert F, Schmid U (1989) Identification of plasmacytoid T cells in lymphoid hyperplasia of the skin. Arch Dermatol 125:1518–1524

    Article  CAS  PubMed  Google Scholar 

  31. Edwards AD, Diebold SS, Slack EM, Tomizawa H, Hemmi H, Kaisho T, Akira S, Sousa CR (2003) Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol 33:827–833

    Article  CAS  PubMed  Google Scholar 

  32. Facchetti F, De-Wolf-Peeters C (1991) The plasmacytoid monocyte (the so-called plasmacytoid T-cell). An enigmatic cell of the human lymphoid tissue. Biotest Bulletin 4:225–240

    Google Scholar 

  33. Facchetti F, Vermi W (2002) Plasmacytoid monocytes and plasmacytoid dendritic cells. Immune system cells linking innate and acquired immunity. Pathologica 94:163–175

    Article  CAS  PubMed  Google Scholar 

  34. Facchetti F, de Wolf-Peeters C, Mason DY, Pulford K, van den Oord JJ, Desmet VJ (1988) Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin. Am J Pathol 133:15–21

    CAS  PubMed  Google Scholar 

  35. Facchetti F, De Wolf-Peeters C, van den Oord JJ, De vos R, Desmet VJ (1988) Plasmacytoid T cells: a cell population normally present in the reactive lymph node. An immunohistochemical and electronmicroscopic study. Hum Pathol 19:1085–1092

    CAS  PubMed  Google Scholar 

  36. Facchetti F, De Wolf-Peeters C, De Vos R, van den Oord JJ, Pulford KA, Desmet VJ (1989) Plasmacytoid monocytes (so-called plasmacytoid T cells) in granulomatous lymphadenitis. Hum Pathol 20:588–593

    CAS  PubMed  Google Scholar 

  37. Facchetti F, De Wolf-Peeters C, van den Oord JJ, Desmet VJ (1989) Plasmacytoid monocytes (so-called plasmacytoid T cells) in Hodgkin’s disease. J Pathol 158:57–65

    CAS  PubMed  Google Scholar 

  38. Facchetti F, De Wolf Peeters C, Van Den Oord JJ, De Vos R, Desmet VJ (1989) Plasmacytoid monocytes (so-called plasmacytoid T-cells) in Kikuchi’s lymphadenitis. An immunohistologic study. Am J Clin Pathol 92:42–50

    CAS  PubMed  Google Scholar 

  39. Facchetti F, de Wolf-Peeters C, van den Oord JJ, Meijer CJ, Pals ST, Desmet VJ (1989) Anti-high endothelial venule monoclonal antibody HECA-452 recognizes plasmacytoid T cells and delineates an “extranodular” compartment in the reactive lymph node. Immunol Lett 20:277–281

    Article  CAS  PubMed  Google Scholar 

  40. Facchetti F, Boden G, De Wolf Peeters C, Vandaele R, Degreef H, Desmet VJ (1990) Plasmacytoid monocytes in Jessner’s lymphocytic infiltration of the skin. Am J Dermatopathol 12:363–369

    CAS  PubMed  Google Scholar 

  41. Facchetti F, De Wolf-Peeters C, Kennes C, Rossi G, De Vos R, van den Oord JJ, Desmet VJ (1990) Leukemia-associated lymph node infiltrates of plasmacytoid monocytes (so-called plasmacytoid T-cells). Evidence for two distinct histological and immunophenotypical patterns. Am J Surg Pathol 14:101–112

    CAS  Google Scholar 

  42. Facchetti F, Blanzuoli L, Ungari M, Alebardi O, Vermi W (1998) Lymph node pathology in primary combined immunodeficiency diseases. Springer Semin Immunopathol 19:459–478

    CAS  PubMed  Google Scholar 

  43. Facchetti F, Vergoni F, Rossi E, Ungari M, Vermi W, Grigolato PG, Frizzera G (2002) Neoplastic nature of nodal plasmacytoid monocytes associated with acute myeloid leukemia. Mod Pathol 15:239A

    Google Scholar 

  44. Facchetti F, Vermi W, Santoro A, Vergoni F, Chilosi M, Doglioni C (2003) Neoplasms derived from plasmacytoid monocytes/interferon producing cells. Variability of CD56 and Granzyme B expression. Am J Surg Pathol (in press)

  45. Farkas L, Beiske K, Lund-Johansen F, Brandtzaeg P, Jahnsen FL (2001) Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions. Am J Pathol 159:237–243

    CAS  PubMed  Google Scholar 

  46. Feldman S, Stein D, Amrute S, Denny T, Garcia Z, Kloser P, Sun Y, Megjugorac N, Fitzgerald-Bocarsly P (2001) Decreased interferon-alpha production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. Clin Immunol 101:201–210

    Article  CAS  PubMed  Google Scholar 

  47. Ferry JA, Harris NL (1999) Plasmacytoid monocytes? Am J Clin Pathol 111:569

    CAS  PubMed  Google Scholar 

  48. Feuillard J, Jacob MC, Valensi F, Maynadie M, Gressin R, Chaperot L, Arnoulet C, Brignole-Baudouin F, Drenou B, Duchayne E, Falkenrodt A, Garand R, Homolle E, Husson B, Kuhlein E, Le Calvez G, Sainty D, Sotto MF, Trimoreau F, Bene MC (2002) Clinical and biologic features of CD4(+)CD56(+) malignancies. Blood 99:1556–1563

    Article  CAS  PubMed  Google Scholar 

  49. Fitzgerald-Bocarsly P (1993) Human natural interferon-alpha producing cells. Pharmacol Ther 60:39–62

    Article  CAS  PubMed  Google Scholar 

  50. Fong L, Engleman EG (2000) Dendritic cells in cancer immunotherapy. Annu Rev Immunol 18:245–273

    CAS  PubMed  Google Scholar 

  51. Fong L, Mengozzi M, Abbey NW, Herndier BG, Engleman EG (2002) Productive infection of plasmacytoid dendritic cells with human immunodeficiency virus type 1 is triggered by CD40 ligation. J Virol 76:11033–11041

    Article  CAS  PubMed  Google Scholar 

  52. Fonteneau JF, Gilliet M, Larsson M, Dasilva I, Munz C, Liu YJ, Bhardwaj N (2003) Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity. Blood 2:2

    Google Scholar 

  53. Frizzera G (1988) Castleman’s disease and related disorders. Semin Diagn Pathol 5:346–364

    CAS  PubMed  Google Scholar 

  54. Galibert L, Maliszewski CR, Vandenabeele S (2001) Plasmacytoid monocytes/T cells: a dendritic cell lineage? Semin Immunol 13:283–289

    Article  CAS  PubMed  Google Scholar 

  55. Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J, Cornelissen IL, Nottet HS, KewalRamani VN, Littman DR, Figdor CG, van Kooyk Y (2000) DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100:587–597

    CAS  PubMed  Google Scholar 

  56. Gilliet M, Liu YJ (2002) Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells. Hum Immunol 63:1149–1155

    Article  CAS  PubMed  Google Scholar 

  57. Gilliet M, Liu YJ (2002) Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J Exp Med 195:695–704

    Article  CAS  PubMed  Google Scholar 

  58. Gilliet M, Boonstra A, Paturel C, Antonenko S, Xu XL, Trinchieri G, O’Garra A, Liu YJ (2002) The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J Exp Med 195:953–958

    Article  CAS  PubMed  Google Scholar 

  59. Grouard G, Rissoan MC, Filgueira L, Durand I, Banchereau J, Liu YJ (1997) The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 185:1101–1111

    Article  CAS  PubMed  Google Scholar 

  60. Gutterman JU (1994) Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A 91:1198–1205

    CAS  PubMed  Google Scholar 

  61. Haase AT (1999) Population biology of HIV-1 infection: viral and CD4+ T cell demographics and dynamics in lymphatic tissues. Annu Rev Immunol 17:625–656

    Article  CAS  PubMed  Google Scholar 

  62. Harris NL, Bhan AK (1987) “Plasmacytoid T cells” in Castleman’s disease. Immunohistologic phenotype. Am J Surg Pathol 11:109–113

    CAS  PubMed  Google Scholar 

  63. Harris NL, Demirjian Z (1991) Plasmacytoid T-zone cell proliferation in a patient with chronic myelomonocytic leukemia: histologic and immunohistologic characterization. Am J Surg Pathol 15:87–95

    CAS  PubMed  Google Scholar 

  64. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S (2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 3:196–200

    Article  CAS  PubMed  Google Scholar 

  65. Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D (2003) TCL1 expression in plasmacytoid dendritic cells (DC2) and the related CD4+ CD56+ blastic tumors of skin. Blood 6:6

    Google Scholar 

  66. Hirst CE, Buzza MS, Bird CH, Warren HS, Cameron PU, Zhang M, Ashton-Rickardt PG, Bird PI (2003) The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. J Immunol 170:805–815

    CAS  PubMed  Google Scholar 

  67. Hochrein H, O’Keeffe M,Wagner H (2002) Human and mouse plasmacytoid dendritic cells. Hum Immunol 63:1103–1110

    Article  CAS  PubMed  Google Scholar 

  68. Horny HP, Feller AC, Horst HA, Lennert K (1987) Immunocytology of plasmacytoid T cells: marker analysis indicates a unique phenotype of this enigmatic cell. Hum Pathol 18:28–32

    CAS  PubMed  Google Scholar 

  69. Horny HP, Kaiserling E, Handgretinger R, Ruck P, Frank D, Weber R, Jaschonek KG, Waller HD (1995) Evidence for a lymphotropic nature of circulating plasmacytoid monocytes: findings from a case of CD56+ chronic myelomonocytic leukemia. Eur J Haematol 54:209–216

    CAS  PubMed  Google Scholar 

  70. Ito T, Amakawa R, Fukuhara S (2002) Roles of toll-like receptors in natural interferon-producing cells as sensors in immune surveillance. Hum Immunol 63:1120–1125

    Article  CAS  PubMed  Google Scholar 

  71. Ito T, Amakawa R, Kaisho T, Hemmi H, Tajima K, Uehira K, Ozaki Y, Tomizawa H, Akira S, Fukuhara S (2002) Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J Exp Med 195:1507–1512

    Article  CAS  PubMed  Google Scholar 

  72. Jahnsen FL, Lund-Johansen F, Dunne JF, Farkas L, Haye R, Brandtzaeg P (2000) Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy. J Immunol 165:4062–4068

    CAS  PubMed  Google Scholar 

  73. Jahnsen FL, Farkas L, Lund-Johansen F, Brandtzaeg P (2002) Involvement of plasmacytoid dendritic cells in human diseases. Hum Immunol 63:1201–1205

    Article  CAS  PubMed  Google Scholar 

  74. Kadowaki N, Antonenko S, Lau JY, Liu YJ (2000) Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med 192:219–226

    Article  CAS  PubMed  Google Scholar 

  75. Keir ME, Stoddart CA, Linquist-Stepps V, Moreno ME, McCune JM (2002) IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus. J Immunol 168:325–331

    CAS  PubMed  Google Scholar 

  76. Khoury JD, Medeiros LJ, Manning JT, Sulak LE, Bueso-Ramos C, Jones D (2002) CD56(+) TdT(+) blastic natural killer cell tumor of the skin: a primitive systemic malignancy related to myelomonocytic leukemia. Cancer 94:2401–2408

    Article  CAS  PubMed  Google Scholar 

  77. Krug A, Towarowski A, Britsch S, Rothenfusser S, Hornung V, Bals R, Giese T, Engelmann H, Endres S, Krieg AM, Hartmann G (2001) Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 31:3026–3037

    PubMed  Google Scholar 

  78. Krug A, Uppaluri R, Facchetti F, Dorner BG, Sheehan KC, Schreiber RD, Cella M, Colonna M (2002) IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation. J Immunol 169:6079–6083

    CAS  PubMed  Google Scholar 

  79. Lennert K, Remmele W (1958) Karyometrische Untersuchungen an Lymphknotenzellen des Menschen: I. Mitt. Germinoblasten, Lymphoblasten und Lymphozyten. Acta Haematol (Basel) 19:99–113

    Google Scholar 

  80. Lennert K, Kaiserling E, Muller-Hermelink HK (1975) T-associated plasma-cells. Lancet 1:1031–1032

    Article  CAS  Google Scholar 

  81. Lian ZX, Okada T, He XS, Kita H, Liu YJ, Ansari AA, Kikuchi K, Ikehara S, Gershwin ME (2003) Heterogeneity of dendritic cells in the mouse liver: identification and characterization of four distinct populations. J Immunol 170:2323–2330

    CAS  PubMed  Google Scholar 

  82. Liu YJ (2001) Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 106:259–262

    CAS  PubMed  Google Scholar 

  83. Manfra DJ, Chen SC, Jensen KK, Fine JS, Wiekowski MT, Lira SA (2003) Conditional expression of murine flt3 ligand leads to expansion of multiple dendritic cell subsets in peripheral blood and tissues of transgenic mice. J Immunol 170:2843–2852

    CAS  PubMed  Google Scholar 

  84. Maraskovsky E, Daro E, Roux E, Teepe M, Maliszewski CR, Hoek J, Caron D, Lebsack ME, McKenna HJ (2000) In vivo generation of human dendritic cell subsets by Flt3 ligand. Blood 96:878–884

    CAS  PubMed  Google Scholar 

  85. Martin P, Del Hoyo GM, Anjuere F, Arias CF, Vargas HH, Fernandez LA, Parrillas V, Ardavin C (2002) Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood 100:383–390

    Article  CAS  PubMed  Google Scholar 

  86. Matsuda H, Suda T, Hashizume H, Yokomura K, Asada K, Suzuki K, Chida K, Nakamura H (2002) Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic cells in peripheral blood of patients with asthma. Am J Respir Crit Care Med 166:1050–1054

    Article  PubMed  Google Scholar 

  87. Miller RL, Gerster JF, Owens ML, Slade HB, Tomai MA (1999) Imiquimod applied topically: a novel immune response modifier and new class of drug. Int J Immunopharmacol 21:1–14

    Article  CAS  PubMed  Google Scholar 

  88. Mohty M, Jarrossay D, Lafage-Pochitaloff M, Zandotti C, Briere F, de Lamballeri XN, Isnardon D, Sainty D, Olive D, Gaugler B (2001) Circulating blood dendritic cells from myeloid leukemia patients display quantitative and cytogenetic abnormalities as well as functional impairment. Blood 98:3750–3756

    Article  CAS  PubMed  Google Scholar 

  89. Mohty M, Isnardon D, Vey N, Briere F, Blaise D, Olive D, Gaugler B (2002) Low blood dendritic cells in chronic myeloid leukaemia patients correlates with loss of CD34+/CD38- primitive haematopoietic progenitors. Br J Haematol 119:115–118

    Article  PubMed  Google Scholar 

  90. Mongkonsritragoon W, Letendre L, Qian J, Li CY (1998) Nodular lesions of monocytic component in myelodysplastic syndrome. Am J Clin Pathol 110:154–162

    CAS  PubMed  Google Scholar 

  91. Müller-Hermelink HK, Steinmann G, Stein H, Lennert K (1983) Malignant lymphoma of plasmacytoid T cells. Morphologic and immunologic studies characterizing a special type of T-cell. Am J Surg Pathol 7:849–862

    PubMed  Google Scholar 

  92. Nakano H, Yanagita M,Gunn MD (2001) CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J Exp Med 194:1171–1178

    Article  CAS  PubMed  Google Scholar 

  93. O’Doherty U, Peng M, Gezelter S, Swiggard WJ, Betjes M, Bhardwaj N, Steinman RM (1994) Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 82:487–493

    CAS  PubMed  Google Scholar 

  94. Okada T, Lian ZX, Naiki M, Ansari AA, Ikehara S, Gershwin ME (2003) Murine thymic plasmacytoid dendritic cells. Eur J Immunol 33:1012–1019

    Article  CAS  PubMed  Google Scholar 

  95. O’Keeffe M, Hochrein H, Vremec D, Caminschi I, Miller JL, Anders EM, Wu L, Lahoud MH, Henri S, Scott B, Hertzog P, Tatarczuch L, Shortman K (2002) Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J Exp Med 196:1307–1319

    Article  CAS  PubMed  Google Scholar 

  96. O’Keeffe M, Hochrein H, Vremec D, Scott B, Hertzog P, Tatarczuch L, Shortman K (2002) Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors. Blood 10:10

    Google Scholar 

  97. Olweus J, BitMansour A, Warnke R, Thompson PA, Carballido J, Picker LJ, Lund-Johansen F (1997) Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin. Proc Natl Acad Sci U S A 94:12551–12556

    PubMed  Google Scholar 

  98. Patterson S, Rae A, Hockey N, Gilmour J, Gotch F (2001) Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus. J Virol 75:6710–6713

    Article  CAS  PubMed  Google Scholar 

  99. Penna G, Sozzani S, Adorini L (2001) Cutting edge: selective usage of chemokine receptors by plasmacytoid dendritic cells. J Immunol 167:1862–1866

    CAS  PubMed  Google Scholar 

  100. Penna G, Vulcano M, Roncari A, Facchetti F, Sozzani S, Adorini L (2002) Cutting edge: differential chemokine production by myeloid and plasmacytoid dendritic cells. J Immunol 169:6673–6676

    CAS  PubMed  Google Scholar 

  101. Penna G, Vulcano M, Sozzani S, Adorini L (2002) Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells. Hum Immunol 63:1164–1171

    Article  CAS  PubMed  Google Scholar 

  102. Petrella T, Dalac S, Maynadie M, Mugneret F, Thomine E, Courville P, Joly P, Lenormand B, Arnould L, Wechsler J, Bagot M, Rieux C, Bosq J, Avril MF, Bernheim A, Molina T, Devidas A, Delfau-Larue MH, Gaulard P, Lambert D (1999) CD4+ CD56+ cutaneous neoplasms: a distinct hematological entity? Groupe Francais d’Etude des Lymphomes Cutanes (GFELC). Am J Surg Pathol 23:137–146

    Article  CAS  PubMed  Google Scholar 

  103. Petrella T, Comeau MR, Maynadie M, Couillault G, De Muret A, Maliszewski CR, Dalac S, Durlach A, Galibert L (2002) ‘Agranular CD4+ CD56+ hematodermic neoplasm’ (blastic NK-cell lymphoma) originates from a population of CD56+ precursor cells related to plasmacytoid monocytes. Am J Surg Pathol 26:852–862

    Article  PubMed  Google Scholar 

  104. Pileri S, Kikuchi M, Helbron D, Lennert K (1982) Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch A Pathol Anat Histol 395:257–271

    CAS  PubMed  Google Scholar 

  105. Prasthofer EF, Prchal JT, Grizzle WE, Grossi CE (1985) Plasmacytoid-T-cell lymphoma associated with chronic myeloproliferative disorder. Am J Surg Pathol 9:380–387

    CAS  PubMed  Google Scholar 

  106. Pulendran B, Banchereau J, Burkeholder S, Kraus E, Guinet E, Chalouni C, Caron D, Maliszewski C, Davoust J, Fay J, Palucka K (2000) Flt3-ligand and granulocyte colony-stimulating factor mobilize distinct human dendritic cell subsets in vivo. J Immunol 165:566–572

    CAS  PubMed  Google Scholar 

  107. Rissoan MC, Duhen T, Bridon JM, Bendriss-Vermare N, Peronne C, de Saint Vis B, Briere F, Bates EE (2002) Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood 100:3295–3303

    Article  CAS  PubMed  Google Scholar 

  108. Ronnblom L, Alm GV (2001) A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J Exp Med 194:F59–F63

    Article  CAS  PubMed  Google Scholar 

  109. Rothenfusser S, Tuma E, Endres S, Hartmann G (2002) Plasmacytoid dendritic cells: the key to CpG(1). Hum Immunol 63:1111–1119

    Article  CAS  PubMed  Google Scholar 

  110. Salio M, Cella M, Vermi W, Facchetti F, Palmowski MJ, Smith CL, Shepherd D, Colonna M, Cerundolo V (2003) Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions. Eur J Immunol 33:1052–1062

    Article  CAS  PubMed  Google Scholar 

  111. Schiavoni G, Mattei F, Sestili P, Borghi P, Venditti M, Morse HC, 3rd, Belardelli F, Gabriele L (2002) ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J Exp Med 196:1415–1425

    Article  CAS  PubMed  Google Scholar 

  112. Scrader JW (2003) Interleukin 3. In: Thomas AW, Lotze MT (eds) The cytokine handbook, Academic Press, London, pp 201–225

  113. Shodell M, Siegal FP (2002) Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing. Scand J Immunol 56:518–521

    Article  CAS  PubMed  Google Scholar 

  114. Shortman K, Liu YJ (2002) Mouse and human dendritic cell subtypes. Nature Rev Immunol 2:151–161

    Article  CAS  Google Scholar 

  115. Siegal FP, Lopez C, Fitzgerald PA, Shah K, Baron P, Leiderman IZ, Imperato D, Landesman S (1986) Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity. J Clin Invest 78:115–123

    CAS  PubMed  Google Scholar 

  116. Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, Ho S, Antonenko S, Liu YJ (1999) The nature of the principal type 1 interferon-producing cells in human blood (see comments). Science 284:1835–1837

    Article  CAS  PubMed  Google Scholar 

  117. Siegal FP, Fitzgerald-Bocarsly P, Holland BK, Shodell M (2001) Interferon-alpha generation and immune reconstitution during antiretroviral therapy for human immunodeficiency virus infection. Aids 15:1603–1612

    Article  CAS  PubMed  Google Scholar 

  118. Soilleux EJ, Morris LS, Leslie G, Chehimi J, Luo Q, Levroney E, Trowsdale J, Montaner LJ, Doms RW, Weissman D, Coleman N, Lee B (2002) Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. J Leukoc Biol 71:445–457

    CAS  PubMed  Google Scholar 

  119. Sorg RV, Kogler G, Wernet P (1999) Identification of cord blood dendritic cells as an immature CD11c- population. Blood 93:2302–2307

    CAS  PubMed  Google Scholar 

  120. Soumelis V, Scott I, Gheyas F, Bouhour D, Cozon G, Cotte L, Huang L, Levy JA, Liu YJ (2001) Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients. Blood 98:906–912

    Article  CAS  PubMed  Google Scholar 

  121. Soumelis V, Scott I, Liu YJ, Levy J (2002) Natural type 1 interferon producing cells in HIV infection. Hum Immunol 63:1206–1212

    Article  CAS  PubMed  Google Scholar 

  122. Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271–296

    PubMed  Google Scholar 

  123. Svensson H, Cederblad B, Lindahl M, Alm G (1996) Stimulation of natural interferon-alpha/beta-producing cells by Staphylococcus aureus. J Interferon Cytokine Res 16:7–16

    CAS  PubMed  Google Scholar 

  124. Vallin H, Blomberg S, Alm GV, Cederblad B, Ronnblom L (1999) Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-alpha (IFN-alpha) production acting on leucocytes resembling immature dendritic cells. Clin Exp Immunol 115:196–202

    Article  CAS  PubMed  Google Scholar 

  125. van den Oord JJ, de Wolf-Peeters C,Desmet VJ (1986) The composite nodule. A structural and functional unit of the reactive human lymph node. Am J Pathol 122:83–91

    PubMed  Google Scholar 

  126. Vermi W, Bonecchi R, Facchetti F, Bianchi D, Sozzani S, Festa S, Berenzi A, Cella M, Colonna M (2003) Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas. J Pathol 200:255–268

    Article  PubMed  Google Scholar 

  127. Vollenweider R, Lennert K (1983) Plasmacytoid T-cell clusters in non-specific lymphadenitis. Virchows Arch 44:1–14

    CAS  Google Scholar 

  128. Waller EK, Rosenthal H, Jones TW, Peel J, Lonial S, Langston A, Redei I, Jurickova I, Boyer MW (2001) Larger numbers of CD4(bright) dendritic cells in donor bone marrow are associated with increased relapse after allogeneic bone marrow transplantation. Blood 97:2948–2956

    PubMed  Google Scholar 

  129. Wollenberg A, Wagner M, Gunther S, Towarowski A, Tuma E, Moderer M, Rothenfusser S, Wetzel S, Endres S, Hartmann G (2002) Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases. J Invest Dermatol 119:1096–1102

    Article  CAS  PubMed  Google Scholar 

  130. Zou W, Borvak J, Wei S, Isaeva T, Curiel DT, Curiel TJ (2001) Reciprocal regulation of plasmacytoid dendritic cells and monocytes during viral infection. Eur J Immunol 31:3833–3839

    Article  CAS  PubMed  Google Scholar 

  131. Zou W, Machelon V, Coulomb-L’Hermin A, Borvak J, Nome F, Isaeva T, Wei S, Krzysiek R, Durand-Gasselin I, Gordon A, Pustilnik T, Curiel DT, Galanaud P, Capron F, Emilie D, Curiel TJ (2001) Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat Med 7:1339–1346

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors wish to thank Amanda Blasius and Anne Krug for their critical comments to the manuscript. The enthusiastic technical support of Silvana Festa, Francesca Gentili, Wilma Pellegrini, Anna Galletti and the secretarial assistance of Gisella Scibè were also greatly appreciated.

Author information

Authors and Affiliations

  1. Department of Pathology, University of Brescia, Brescia, Italy

    Fabio Facchetti & William Vermi

  2. Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom

    David Mason

  3. Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA

    Marco Colonna

Authors
  1. Fabio Facchetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. William Vermi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David Mason
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Marco Colonna
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fabio Facchetti.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Facchetti, F., Vermi, W., Mason, D. et al. The plasmacytoid monocyte/interferon producing cells. Virchows Arch 443, 703–717 (2003). https://doi.org/10.1007/s00428-003-0918-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-003-0918-8

Keywords

Search

Navigation