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Accuracy of intra-operative PTH measurement during subtotal parathyroidectomy for tertiary hyperparathyroidism after renal transplantation

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Abstract

Background and aims

Intra-operative parathyroid hormone (IOPTH) results are not known in the setting of tertiary hyperparathyroidism (HPT) after renal transplantation.

Materials and methods

A retrospective analysis of 35 tertiary HPT patients who all underwent subtotal parathyroidectomy and IOPTH monitoring was conducted.

Results

The mean follow-up time was 2.2±1.4 years. Thirty-four patients were cured; one patient (2.8%) had a persistent disease and was cured after reoperation. Median parathyroid hormone (PTH) (median percent decrease from highest) at baseline and at 5, 10, 20, and 30 min were 244, 78 (69%), 63 (75%), 53 (79%), and 49 pg/ml (83%), respectively. Four patients who were cured had a decrease of <50% at 5 min and two of them had a decrease of <50% at 10 min. The patient with persistent disease had a decrease of >50% at 10 min. The sensitivity of the test was 94% at 10 min using the Miami criteria.

Conclusion

This study shows that IOPTH in tertiary hyperparathyroidism has a high sensitivity. However, because of the low risk of persistent hyperparathyroidism when a subtotal parathyroidectomy is performed, its potential impact on the overall success rate is very small. We therefore do not recommend the routine use of IOPTH in tertiary hyperparathyroidism.

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Acknowledgements

We thank Dr. R. Azar, Dr. F. Dequiedt, Dr. P. Duchatelle, Dr. F. Dumont, Dr. D. Fleury, Dr. F. Lamotte, Dr. H. Lemonies de Sagazan, Dr. A. Tacquet, Dr. V. Lemaitre, Dr. P. Vanhille, and Dr. F. Wambergue for their help in the clinical follow-up of these patients. F.T. was supported by a grant from the University Hospital of Geneva for his fellowship in Lille.

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Authors and Affiliations

  1. General and Endocrine Surgery, University Hospital of Lille, 59037, Lille, France

    Frederic Triponez, David Dosseh, Jonathan Lokey, Martha Mozzon & Charles A. G. Proye

  2. Nephrology and Hemodialysis, University Hospital of Lille, 59037, Lille, France

    Marc Hazzan & Christian Noel

  3. Laboratory of Endocrinological Biochemistry, University Hospital of Lille, 59037, Lille, France

    Benoit Soudan

  4. Thoracic and Endocrine Surgery, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland

    Frederic Triponez

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  1. Frederic Triponez
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  2. David Dosseh
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  3. Marc Hazzan
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  4. Christian Noel
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Correspondence to Frederic Triponez.

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Triponez, F., Dosseh, D., Hazzan, M. et al. Accuracy of intra-operative PTH measurement during subtotal parathyroidectomy for tertiary hyperparathyroidism after renal transplantation. Langenbecks Arch Surg 391, 561–565 (2006). https://doi.org/10.1007/s00423-006-0070-4

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  • DOI: https://doi.org/10.1007/s00423-006-0070-4

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