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Influence of training on markers of platelet activation in response to a bout of heavy resistance exercise

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Abstract

Recent connections between platelet activity and cardiovascular disease have raised questions of whether platelet function varies in exercising individuals. Resistance training has been linked to a possible reduction in hyper-aggregability of platelets, especially following acute strenuous exercise. The present investigation was designed to explore the effects of an acute resistance exercise test on the primary hemostatic system in both resistance-trained (RT) and untrained (UT) individuals. Ten RT (five men and five women; age, 26.0 ± 4.5 years; height, 175.12 ± 8.54 cm; weight, 79.56 ± 13.56 kg) and ten UT (five men and five women; age, 26.4 ± 6.2 years; height, 170.31 ± 7.45 cm; weight 67.88 ± 16.90 kg) individuals performed an Acute Exhaustive Resistance Exercise Test (AERET; six sets of ten repetitions of squats at 80 % of the 1-Repetition Maximum (RM)). Blood samples were obtained before, immediately after, and at 15, 60, and 120 min following the AERET. Blood samples were analyzed for platelet count, von Willebrand factor antigen (vWF:Ag), beta-thromboglobulin (β-TG), and platelet factor 4 (PF4). B-TG showed significant differences (p < 0.05) between RT and UT at +15 and +60 min. Both groups showed a main effect for time in platelet count, vWF, and β-TG following the AERET, whereas PF4 remained unchanged. All blood variables returned to baseline 120 min after exercise. Compared with UT, RT demonstrated reduced platelet activation in response to an acute bout of heavy resistance exercise. Reduced platelet activation may be attributed to training status, as shown by a reduction in plasma concentrations of B-TG in the RT group.

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Acknowledgments

The authors are grateful to our research and medical staff and to a dedicated group of test subjects for their participation in the study. Current Address: Dr. Juan Aristizabal School of Nutrition and Dietetics, University of Antioquia, Carrera, 75 #56-87, Medellin, Columbia.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 2095 Hillside Road, Unit 1110 Gampel Pavilion, Room 203, Storrs, CT, 06269-1110, USA

    William J. Kraemer

  2. Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 2095 Hillside Road, Unit 1110 Gampel Pavilion, Storrs, CT, 06269-1110, USA

    Brent C. Creighton, Brian R. Kupchak, Juan C. Aristizabal, Shawn D. Flanagan, Courtenay Dunn-Lewis, Brittanie M. Volk, Brett A. Comstock, Jeff S. Volek, David R. Hooper, Tunde K. Szivak & Carl M. Maresh

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  1. Brent C. Creighton
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Correspondence to William J. Kraemer.

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Communicated by Dag Linnarsson.

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Creighton, B.C., Kupchak, B.R., Aristizabal, J.C. et al. Influence of training on markers of platelet activation in response to a bout of heavy resistance exercise. Eur J Appl Physiol 113, 2203–2209 (2013). https://doi.org/10.1007/s00421-013-2645-4

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