Abstract
Objectives: This study explores several factors potentially associated with reduced fecundability among women working in cut flowers production. Methods: A cross-sectional study of first pregnancies was undertaken in 47 Colombian floriculture companies. Two thousand and eighty-five women were interviewed regarding potential reproductive, lifestyle and work history predictors of time-to-pregnancy (TTP), measured in months. Fecundability odds ratios (fOR) were estimated using a discrete time analogue of Cox’s proportional hazard model. Results: Associated with longer TTP were: irregular relationships with her partner (fOR 0.82, 95% CI 0.73–0.91), illness in the year prior to pregnancy (fOR 0.78, 95% CI 0.62–0.98), smoking tobacco (fOR 0.71, 95% CI 0.59–0.85), and work in flower production, less than 24 months (fOR 0.86 95% CI 0.75–0.98) or 2 years or more (fOR 0.73, 95% CI 0.63–0.84). Conclusions: Work in flower production, irregular relationship, illness and tobacco exposure would be associated with impaired fecundability.
Similar content being viewed by others
References
Abell A, Juul S, Bonde JPE (2000) Time to pregnancy among female greenhouse workers. Scand J Work Environ Health 26:131–136
Akre O, Cnattingius S, Bergström R, Kvist U, Trichopoulos D, Ekbom A (1999) Human fertility does not decline: evidence from Sweden. Fertil Steril 71:1066–1069
Baird DD, Wilcox AJ, Weinberg CR (1986) Use of time to pregnancy to study environmental exposures. Am J Epidemiol 124:470–480
Baird DD, Weinberg CR, Rowland AS (1991) Reporting errors in time-to-pregnancy data collected with a short questionnaire. Impact on power and estimation of fecundability ratios. Am J Epidemiol 133:1282–1290
Brouwer DH, Brouwer R, De Milk G, Maas CL, van Hemmen JJ (1992a) Pesticides in the cultivation of carnations in greenhouses; part I: exposure and concomitant health risk. Am Ind Hyg Assoc J 53:575–581
Brouwer DH, Brouwer R, Tijssen S, van Hemmen JJ (1992b) Pesticides in the cultivation of carnations in greenhouses; part II: relationship between foliar residues and exposures. Am Ind Hyg Assoc J 53:582–587
Cristosomo L, Molina VV (2002) Pregnancy outcomes of farming households in Neuva Ecija with conventional pesticide use versus integrated pest management. Int J Occup Environ Health 8:243–248
Curtis KM, Savitz DA, Weinberg CR, Arbuckle TE (1999) The effect of pesticide exposure on time to pregnancy. Epidemiology 10:112–117
De Cock J, Westveer K, Heederik D, te Velde E, van Kooij R (1994) Time to pregnancy and occupational exposure to pesticides in fruit growers in The Netherlands. Occup Environ Med 51:693–699
Dinno A (2002) DTHAZ: Stata module to compute discrete-time hazard and survival probability. Available in: http://ideas.repec.org/c/boc/bocode/s420701.html
Florack EI, Zielhuis GA, Rolland R (1994) The influence of occupational physical activity on the menstrual cycle and fecundability. Epidemiology 5:14–18
Hanke W, Jurewicz J (2004) The risk of adverse reproductive and developmental disorders due to occupational pesticide exposure: an overview of current epidemiological evidence. Int J Occup Environ Health 17:223–243
Hjollund TB, Jensen TK, Bonde JP, Henriksen TB, Andersson AM, Kolstad HA, Ernst E, Giwercman A, Skakkebaek NE, Olsen J (1999) Distress and reduced fertility: a follow up study of first-pregnancy planners. Fertil Steril 72:47–53
Hosmer DW, Lemeshow S (1989) Applied logistic regression. Wiley, New York
Jensen TK, Hjollund NH, Henriksen TB, Scheike T, Kolstad H, Giwerkman A, Ernst E, Bonde JP, Skakkebaek NE, Olsen J (1998) Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy. BMJ 317:505–510
Jensen TK, Slama R, Ducot B, Suominen J, Cawood EH, Andersen AG, Eustache F, Irvine S, Auger S, Jouannet P, Vierula M, Jorgensen N, Toppari J, Skakkebaek NE, Keiding N, Spira A (2001) Regional differences in waiting time to pregnancy among fertile couples from four European cities. Hum Reprod 16:2697–2704
Joffe M (1997) Time to pregnancy: a measure of reproductive function in either sex. Occup Environ Med 54:289–295
Joffe M (2000) Time trends in biological fertility in Britain. Lancet 355:1961–1965
Joffe M, Villard L, Li Z, Plowman R, Vessey M (1995) A time to pregnancy questionnaire designed for long term recall: validity in Oxford, England. J Epidemiol Community Health 49:314–319
Juhl M, Nyboe Andersen AM, Gronbaek M, Olsen J (2001) Moderate alcohol consumption and waiting time to pregnancy. Hum Reprod 16:2705–2709
Larsen SB, Joffe M, Bonde JP, and the Asclepios Study Group (1998) Time to pregnancy and exposure to pesticides in Danish farmers. Occup Environ Med 55:278–283
Matos EL, Loria DJ, Albiano N, Sobel N, de Buján EC (1988) Efectos de los plaguicidas en trabajadores de cultivos intensivos. Bol Of Sanit Panam 104:160–170
Misra DP, Grason H, Weisman C (2000) An intersection of women’s and perinatal health: the role of chronic conditions. Women’s Health Issues 10:256–267
Nurminen T (1995) Maternal pesticide exposure and pregnancy outcome. J Occup Environ Med 37:935–940
Olsen J (1994) Options in making use of pregnancy history in planning and analysing studies of reproductive failure. J Epidemiol Community Health 48:171–174
Olsen J, Skov T (1993) Design options and methodological fallacies in the studies of reproductive failures. Environ Health Perspect 101(Suppl 2):S145–S152
Parazzini F, Chatenoud E, Di Cintio E, La Vecchia C, Benzi G, Fedele L (1999) Alcohol consumption is not related to fertility in Italian women. BMJ 318:397
Paz-y-Miño C, Bustamante G, Sánchez ME, Leone PE (2002) Cytogenetic monitoring in a population occupationally exposed to pesticides in Ecuador. Environ Health Perspect 110:1077–1080
Petrelli G, Figà-Talamanca I (2001) Reduction in fertility of male greenhouse workers exposed to pesticides. Eur J Epidemiol 17:675–677
Restrepo M, Muñoz N, Day NE, Parra JE, de Romero L, Nguyen-Dinh X (1990a) Prevalence of adverse reproductive outcomes in a population occupationally exposed to pesticides in Colombia. Scand J Work Environ Health 16:232–238
Restrepo M, Muñoz N, Day NE, Parra JE, Hernández C, Blettner M, Giraldo A (1990b) Birth defects among children born to a population occupationally exposed to pesticides in Colombia. Scand J Work Environ Health 16:239–246
Sallmén M, Liesivuori J, Taskinen H, Lindbohm ML, Anttila A, Aalto L, Hemminki K (2003) Time to pregnancy among the wives of Finnish greenhouses workers. Scand J Work Environ Health 29:85–93
Sharara FI, Seifer DB, Flaws JA (1998) Environmental toxicants and female reproduction. Fertil Steril 70:613–622
Singh D (1994) Waist-to-hip ratio and judgment of attractiveness and healthiness of female figures by male and female physicians. Int J Obes Relat Metab Disord 18:731–737
Steenland K, Cedillo L, Tucker J, Hines C, Sorensen K, Deddens J, Cruz V (1997) Thyroid hormones and cytogenetic outcomes in backpack sprayers using ethylenebis(dithiocarbamate) (EBDC) fungicides in Mexico. Environ Health Perspect 105:1126–1130
Tenembaum D (2002) Would a rose not smell as sweet?. Environ Health Perspect 110:A240–A247
Thonneau P, Abell A, Larsen SB, Bonde JP, Joffe M, Clavert A, Ducot B, Multigner L, Danscher G, for the ASCLEPIOS Study Group (1999) Effects of pesticide exposure on time to pregnancy: results of a multicenter study in France and Denmark. ASCLEPIOS Study Group. Am J Epidemiol 150:157–163
Tielemans E, Louwerse E, de Cock J, Brouwer D, Zielhuis G, Heederik D (1999) Exposure to fungicides in fruit growing: Re-entry time as a predictor for dermal exposure. Am Ind Hyg Assoc J 60:789–793
Tolosa J, Varona M, Cárdenas O, Torres C, Pardo D, Carrasquilla G, Durana C, Leiva MC, Frumkin H (2003) Descripción del uso y manejo de plaguicidas en las empresas de flores afiliadas a Asocolflores (Informe presentado a Asocolflores). Bogotá
Weinberg CR, Wilcox AJ (1998) Reproductive epidemiology. In: Rothman KJ, Greenland S (eds) Modern epidemiology, 2nd edn. Lippincott-Raven, Philadelphia, pp 585–608
Weinberg CR, Wilcox AJ, Baird DD (1989) Reduced fecundability in women with prenatal exposure to cigarette smoking. Am J Epidemiol 129:1072–1078
Weinberg CR, Baird DD, Wilcox AJ (1994) Sources of bias in studies of time to pregnancy. Stat Med 13:671–681
Wilcox AJ, Weinberg CR, Baird DD (1995) Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy, and sex of the baby. N Engl J Med 333:1517–1521
World Health Organization (WHO) (1990) Public health impact of pesticides used in agriculture. WHO, Geneva
Zhou H, Weinberg CR (1999) Potential for bias in estimating human fecundability parameters: a comparison of statistical models. Stat Med 18:411–422
Acknowledgments
Thanks to all flower production workers and farm managers who participated in the study, as well as to the Colombian Association of Flower Exporters (Asocolflores) for their collaboration. Thanks also to Selahadin Ibrahim for statistical advice and the Department of public health sciences, School of Medicine, University of Toronto for infrastructural support. This study was supported by the Colombian Institute for the Development of Science and Technology “Francisco José de Caldas”—Colciencias (Contract No. 112-2000) and the Research Division (DIB) at Universidad Nacional de Colombia—Bogotá.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Idrovo, A.J., Sanìn, L.H., Cole, D. et al. Time to first pregnancy among women working in agricultural production. Int Arch Occup Environ Health 78, 493–500 (2005). https://doi.org/10.1007/s00420-005-0615-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00420-005-0615-9