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Pseudoexfoliation syndrome and asymptomatic myocardial dysfunction

  • Clinical Investigation
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Abstract

Background

The purpose of this study was to investigate the frequency of asymptomatic left ventricular dysfunction in patients with pseudoexfoliation syndrome.

Methods

Two-dimensional and pulsed Doppler echocardiography of transmitral flow was performed on 27 patients with pseudoexfoliation syndrome, aged 66.9±5.6 years, and 24 healthy volunteers aged 63.9±6.5 years. Left ventricular (LV) systolic contraction and ejection were assessed by LV ejection fraction (EF) and fractional shortening (FS). LV diastolic filling parameters tested were: early fast diastolic filling (E wave), late diastolic filling (A wave), ratio E/A, velocity time integral E wave (VTIE) and A wave (VTIA), their ratio (VTIE/VTIA), pressure at the end of filling (LVEDP) and a pulmonary capillary wedge pressure (PCWP).

Results

Systolic parameters EF and FS, diastolic filling parameters such as A, LVEDP and PCWP were not significantly different between patients with pseudoexfoliation syndrome and controls (P>0.05). A significant difference (P<0.05) was found with regard to the diastolic filling parameters: E (61.6±15.1 vs 83.7±21.4), ratio E/A (0.8±0.1 vs 1.1±0.2), VTIE (8.6±1.8 vs 9.8±1.9), VTIA (10.3±2.4 vs 7.8±1.6) and ratio VTIA/VTIE (1.2±0.2 vs 0.8±0.2).

Conclusion

Our study suggests the possibility of an association between patients with pseudoexfoliation syndrome and a discrete asymptomatic myocardial diastolic dysfunction.

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Authors and Affiliations

  1. Department of Ophthalmology, Clinical Hospital of Split, Spinčićeva 1, 21000, Split, Croatia

    Lovro Bojić, Milan Ivanišević, Veljko Rogošić & Mladen Lešin

  2. Department of Internal Medicine, Division of Cardiology, Clinical Hospital of Split, Split, Croatia

    Ratko Ermacora & Stojan Polić

  3. Department of Ophthalmology, Zagreb Clinical Hospital of the Sisters of Mercy, Zagreb, Croatia

    Zdravko Mandić

Authors
  1. Lovro Bojić
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  2. Ratko Ermacora
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  3. Stojan Polić
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  4. Milan Ivanišević
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  5. Zdravko Mandić
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  6. Veljko Rogošić
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  7. Mladen Lešin
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Correspondence to Lovro Bojić.

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The authors have no proprietary or financial interest in any research or devices described in the presented study.

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Bojić, L., Ermacora, R., Polić, S. et al. Pseudoexfoliation syndrome and asymptomatic myocardial dysfunction. Graefe's Arch Clin Exp Ophthalmol 243, 446–449 (2005). https://doi.org/10.1007/s00417-004-1074-9

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  • DOI: https://doi.org/10.1007/s00417-004-1074-9

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