Skip to main content
SpringerLink
Log in

Profile of microRNAs in the plasma of Parkinson’s disease patients and healthy controls

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K (2004) Stages in the development of Parkinson’s disease-related pathology. Cell Tissue Res 318:121–134

    Article  PubMed  Google Scholar 

  2. Nuytemans K, Theuns J, Cruts M, Van Broeckhoven C (2010) Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Hum Mutat 31:763–780

    Article  PubMed  CAS  Google Scholar 

  3. Eacker SM, Dawson TM, Dawson VL (2009) Understanding microRNAs in neurodegeneration. Nat Rev Neurosci 10:837–841

    PubMed  CAS  Google Scholar 

  4. Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G, Abeliovich A (2007) A MicroRNA feedback circuit in midbrain dopamine neurons. Science 317:1220–1224

    Article  PubMed  CAS  Google Scholar 

  5. Wang G, van der Walt JM, Mayhew G, Li YJ, Zuchner S, Scott WK, Martin ER, Vance JM (2008) Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. Am J Hum Genet 82:283–289

    Article  PubMed  CAS  Google Scholar 

  6. Junn E, Lee KW, Jeong BS, Chan TW, Im JY, Mouradian MM (2009) Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci USA 106:13052–13057

    Article  PubMed  CAS  Google Scholar 

  7. Gehrke S, Imai Y, Sokol N, Lu B (2010) Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 466:637–641

    Article  PubMed  CAS  Google Scholar 

  8. Minones-Moyano E, Porta S, Escaramis G, Rabionet R, Iraola S, Kagerbauer B, Espinosa-Parrilla Y, Ferrer I, Estivill X, Marti E (2011) MicroRNA profiling of Parkinson’s disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function. Hum Mol Genet 20:3067–3078

    Article  PubMed  CAS  Google Scholar 

  9. Reid G, Kirschner MB, van Zandwijk N (2011) Circulating microRNAs: association with disease and potential use as biomarkers. Crit Rev Oncol Hematol 80:193–208

    Article  PubMed  Google Scholar 

  10. Olivieri F, Spazzafumo L, Santini G, Lazzarini R, Albertini MC, Rippo MR, Galeazzi R, Abbatecola AM, Marcheselli F, Monti D, Ostan R, Cevenini E, Antonicelli R, Franceschi C, Procopio AD (2012) Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging. Mech Ageing Dev 133:675–685

    Article  PubMed  CAS  Google Scholar 

  11. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184

    Article  PubMed  CAS  Google Scholar 

  12. Geekiyanage H, Jicha GA, Nelson PT, Chan C (2012) Blood serum miRNA: non-invasive biomarkers for Alzheimer’s disease. Exp Neurol 235:491–496

    Article  PubMed  CAS  Google Scholar 

  13. Li X, Khanna A, Li N, Wang E (2011) Circulatory miR34a as an RNA based, noninvasive biomarker for brain aging. Aging (Albany NY) 3:985–1002

    CAS  Google Scholar 

  14. Martins M, Rosa A, Guedes LC, Fonseca BV, Gotovac K, Violante S, Mestre T, Coelho M, Rosa MM, Martin ER, Vance JM, Outeiro TF, Wang L, Borovecki F, Ferreira JJ, Oliveira SA (2011) Convergence of miRNA expression profiling, alpha-synuclein interaction and GWAS in Parkinson’s disease. PLoS ONE 6:e25443

    Article  PubMed  CAS  Google Scholar 

  15. Margis R, Rieder CR (2011) Identification of blood microRNAs associated to Parkinson’s disease. J Biotechnol 152:96–101

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

Authors thank the “Fundacion Parkinson Asturias” and “Obra Social Cajastur” for their support. This work was supported by grant 11/0093 from the Spanish “Fondo de Investigaciones Sanitarias-Fondos FEDER” European Union. LFC and LDM are predoctoral fellowships of FICYT-Principado de Asturias.

Conflicts of interest

The authors declare no conflicts of interest.

Author information

Authors and Affiliations

  1. Genética Molecular-Laboratorio de Medicina, Hospital Universitario Central de Asturias, Oviedo, Spain

    Lucía F. Cardo, Eliecer Coto, Lorena de Mena & Victoria Alvarez

  2. Neurología, Hospitales Universitario Central Asturias and Álvarez Buylla-Mieres, Asturias, Spain

    Renée Ribacoba, Germán Moris & Manuel Menéndez

  3. Department of Medicine, University of Oviedo, Oviedo, Spain

    Eliecer Coto

  4. Genética Molecular, Hospital Central Asturias-Maternidad, 33006, Oviedo, Spain

    Victoria Alvarez

Authors
  1. Lucía F. Cardo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eliecer Coto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lorena de Mena
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Renée Ribacoba
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Germán Moris
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Manuel Menéndez
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Victoria Alvarez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Victoria Alvarez.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOC 317 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cardo, L.F., Coto, E., de Mena, L. et al. Profile of microRNAs in the plasma of Parkinson’s disease patients and healthy controls. J Neurol 260, 1420–1422 (2013). https://doi.org/10.1007/s00415-013-6900-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-013-6900-8

Keywords

Search

Navigation