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Significant association of metabolic syndrome with silent brain infarction in elderly people

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Abstract

A silent brain infarction (SBI) can predict clinical overt stroke or dementia. Studies focusing on the elderly population, where SBI is most common, are sparse. We examined the associations between SBI and metabolic syndrome (MetS) in healthy elderly individuals. Neurologically healthy subjects (1,254 persons, 723 males) aged ≥65 years who underwent brain MRI were evaluated. MetS was diagnosed following the AHA/NHLBI-2005 criteria. We examined associations between full syndrome (at least three of the five conditions) as well as its components and SBI while controlling for possible confounders. One hundred and ninety-seven subjects (15.7%) were found to have one or more SBIs on MRI. Age (1-year difference) was found to be significantly related to SBI prevalence (OR 1.09; 95% CI 1.05–1.12). MetS was significantly associated with SBI (OR 1.68; 95% CI 1.15–2.44). The component model of MetS showed a strong significance between elevated blood pressure (OR 1.89; 95% CI 1.23–2.91) and SBI. Subjects exhibiting more components of MetS showed more prevalent SBI and multiple SBIs. MetS was found to be significantly associated with SBI in neurologically healthy elderly people. The positive trend between the number of MetS components and SBI could be used as a diagnostic tool to predict and prevent future stroke.

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Acknowledgements

This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare (A060171).

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Authors and Affiliations

  1. Department of Neurology, Seoul National University Boramae Hospital, Seoul, South Korea

    Hyung-Min Kwon, Hyunwoo Nam & Yong-Seok Lee

  2. Department of Neurology, Seoul National University Hospital, Yongon-dong 28, Chongno-gu, Seoul, 110-744, Republic of Korea

    Beom Joon Kim, Wi-Sun Ryu, Chi-Kyung Kim, Su-Ho Lee, Sang-Bae Ko, Seung-Hoon Lee & Byung-Woo Yoon

  3. Healthcare Research Institute, Seoul National University Hospital, Healthcare System Gangnam Center, Seoul, South Korea

    Jin-Ho Park

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  1. Hyung-Min Kwon
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Correspondence to Byung-Woo Yoon.

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Kwon, HM., Kim, B.J., Park, JH. et al. Significant association of metabolic syndrome with silent brain infarction in elderly people. J Neurol 256, 1825–1831 (2009). https://doi.org/10.1007/s00415-009-5201-8

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  • DOI: https://doi.org/10.1007/s00415-009-5201-8

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