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Melanoma complicating treatment with Natalizumab (Tysabri) for multiple sclerosis

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References

  1. Adelman B, Sandrock A, Panzara MA (2005) Natalizumab and progressive multifocal leukoencephalopathy. N Engl J Med 353:432–433

    Article  PubMed  CAS  Google Scholar 

  2. Bauer R, Humphries M, Fassler R, Winklmeier A, Craig SE, Bossehoff AK (2006) Regulation of integrin activity by MIA. J Biol Chem 281:11669–11677

    Article  PubMed  CAS  Google Scholar 

  3. Davenpor RJ, Munday JR (2007) Alpha4-integrin antagonism—an effective approach for the treatment of inflammatory diseases? Drug Discov Today 12(13-14):569

    Article  Google Scholar 

  4. http://investor.biogenidec.com/phoenix.zhtml?c=148682&p=irol-TPME. Accessed 29 April 2009

  5. Kedl RM, Mescher MF (1997) Migration and activation of antigen-specific CD8+ T cells upon in vivo stimulation with allogeneic tumour. J Immunol 159:650–663

    PubMed  CAS  Google Scholar 

  6. Larouche N, Larouche K, Be’liveau A et al (1998) Transcriptional regulation of the alpha 4-integrin subunit gene in the metastatic spread of uveal melanoma. Anticancer Res 18(5a):3539–3547

    PubMed  CAS  Google Scholar 

  7. Mullen JT, Vartanian TK, Atkins MB (2008) Melanoma complicating treatment with natalizumab for multiple sclerosis. N Engl J Med 358(6):647–648

    Article  PubMed  CAS  Google Scholar 

  8. Ogawa M, Tsutsui T, Zou JP et al (1997) Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumour sites following administration of interleukin 12. Cancer Res 57:2216–2222

    PubMed  CAS  Google Scholar 

  9. Panzara MA, Bozic C, Sandrock AW (2008) More on melanoma with transdifferentiation. N Engl J Med 359(1):99

    Article  PubMed  CAS  Google Scholar 

  10. Polman CH, O’Connor PW, Havrdova E et al (2006) A randomised placebo- controlled trial of natalizumab for relapsing multiple sclerosis. N Eng J Med 354:899–910

    Article  CAS  Google Scholar 

  11. Qian F, Vaux DL, Weissman IL (1994) Expression of the integrin alpha 4 beta 1 on melanoma cells can inhibit the invasive stage of metastasis formation. Cell 77(3):335–347

    Article  PubMed  CAS  Google Scholar 

  12. Rudick RA, Stuart WH, Calabresi PA et al (2006) Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med 354:911–923

    Article  PubMed  CAS  Google Scholar 

  13. Stüve O, Marra CM, Bar-Or A et al (2006) Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis. Arch Neurol 63(10):1383–1387

    Article  PubMed  Google Scholar 

  14. Ulrich C, Schmook T, Sachse MM et al (2004) Comparative epidemiology and pathogenic factors for nonmelanoma skin cancer in organ transplant patients. Dermatol Surg 30:622–627

    Article  PubMed  Google Scholar 

  15. Yang Y, Cardarelli PM, Lehnert K et al (1998) LPAM-1 (integrin alpha 4 beta 7)-ligand binding: overlapping binding sites recognizing VCAM-1, MAdCAM-1 and CS-1 are blocked by fibrinogen, a fibronectin-like polymer and RGD-like cyclic peptides. Eur J Immunol 28(3):995–1004

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Basil Sharrack.

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Ismail, A., Kemp, J. & Sharrack, B. Melanoma complicating treatment with Natalizumab (Tysabri) for multiple sclerosis. J Neurol 256, 1771–1772 (2009). https://doi.org/10.1007/s00415-009-5200-9

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  • DOI: https://doi.org/10.1007/s00415-009-5200-9

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