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Immunomodulatory treatment strategies in multiple sclerosis

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Abstract

Multiple sclerosis (MS) represents the prototypic inflammatory autoimmune disorder of the central nervous system and the most common cause of neurological disability in young adults. The mainstays in the immunomodulatory therapy of MS are currently interferon beta and glatiramer acetate, both of which have proven to be clinically and paraclinically effective. Current clinical evidence indicates that treatment should be initiated as early as possible. In this review we summarize available data from clinical studies on clinical efficacy of immunomodulatory drugs for treating patients with multiple sclerosis.

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Authors and Affiliations

  1. Dept. of Neurology, Heinrich-Heine University, Moorenstrasse 5, 40225, Düsseldorf, Germany

    Bernd C. Kieseier &  Verena I. Leussink

  2. Dept. of Neurology, Julius-Maximilians University, Würzburg, Germany

    Heinz Wiendl

  3. Neurology Section, VA North Texas Health Care System Medical Service, Dallas, Texas, USA

    Olaf Stüve

  4. Dept. of Neurology and Dept. of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

    Olaf Stüve

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  1. Bernd C. Kieseier
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  2. Heinz Wiendl
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  3. Verena I. Leussink
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  4. Olaf Stüve
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Correspondence to Bernd C. Kieseier.

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Conflict of interest BCK and HW have received honoraria for speaking at meetings supported by, consulted for or served on advisory boards for: Sanofi Aventis, Bayer Schering, Biogen Idec, Merck Serono, Teva Pharmaceuticals, Novartis.

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Kieseier, B.C., Wiendl, H., Leussink, V.I. et al. Immunomodulatory treatment strategies in multiple sclerosis. J Neurol 255 (Suppl 6), 15–21 (2008). https://doi.org/10.1007/s00415-008-6004-z

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