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Genes associated with Parkinson syndrome

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Abstract

Genetic findings have changed our views on Parkinson’s disease (PD) and parkinsonism, which will be collectively referred to as Parkinsonian Syndrome (PS) in the present manuscript. Mutations in several genes are found to cause monogenic forms of the disorder. Point mutations, duplications and triplications in the α-synuclein gene cause a rare dominant form of PS in families. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as a much more common cause for dominant PS, especially in certain ethnic groups, while mutations in the parkin gene, in DJ-1, PINK1 and ATP13A2 cause autosomal recessive parkinsonism of early onset. The monogenic variants are important tools in identifying cellular pathways that also shed light on the molecular pathogenesis of sporadic PS and some of these genes may play a role in the etiology of the common sporadic form of PS. Here we add recent findings to a greatly challenging puzzle.

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Authors and Affiliations

  1. Dept. of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, Hoppe-Seyler Str. 3, 72076, Tübingen, Germany

    Thomas Gasser

  2. Dept. of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller-Str. 27, Tübingen, Germany

    Saskia Biskup & Thomas Gasser

  3. Dept. of Medical Genetics, University of Tübingen, Calwerstr.7, Tübingen, Germany

    Saskia Biskup

  4. Dept. of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy, Laboratory for Clinical Neurobiology, University of Würzburg, Füchsleinstrasse 15, 97080, Würzburg, Germany

    Manfred Gerlach

  5. Dept. of Neurology, Charité, Campus Virchow, Augustenburger Platz 1, 13353, Berlin, Germany

    Andreas Kupsch

  6. Dept. of Neurology, Technical University of Dresden, Fetscherstraße 74, 01307, Dresden, Germany

    Heinz Reichmann

  7. Dept. of Clinical Neurochemistry, University of Wuerzburg, Fuechsleinstr. 15, 97080, Wuerzburg, Germany

    Peter Riederer

  8. Dept. of Neurology, Klinikum Lippe-Lemgo, Rintelner Straße 85, 32657, Lemgo, Germany

    Peter Vieregge

  9. Dept. of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany

    Ullrich Wüllner

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  1. Saskia Biskup
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  2. Manfred Gerlach
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  3. Andreas Kupsch
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  4. Heinz Reichmann
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  7. Ullrich Wüllner
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  8. Thomas Gasser
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Correspondence to Thomas Gasser.

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Biskup, S., Gerlach, M., Kupsch, A. et al. Genes associated with Parkinson syndrome. J Neurol 255 (Suppl 5), 8–17 (2008). https://doi.org/10.1007/s00415-008-5005-2

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