Skip to main content
SpringerLink
Log in

A hypervariable STR polymorphism in the complement factor I (CFI) gene: Asian-specific alleles

  • Short Communication
  • Published:
International Journal of Legal Medicine Aims and scope Submit manuscript

Abstract

In this study, a short tandem repeat (STR) polymorphism in intron 7 of the human complement factor I (CFI) gene was studied in 637 DNA samples obtained from African, German, Thai, and Japanese populations and German and Japanese families. A total of 41 alleles were observed and classified into two groups, L and H, based on size differences. Group H, which consisted of 16 alleles, was observed only in Thai and Japanese populations at frequencies of 0.162 and 0.116, respectively, and was strongly associated with c.1217A in exon 11 (CFI*Ah). The heterozygosity values ranged from 0.89 in German to 0.93 in Thai populations. This STR would be a useful supplementary marker for forensic individualization.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Schroeder KB, Schurr TG, Long JC et al (2007) A private allele ubiquitous in the Americas. Biol Lett 3:218–223

    Article  CAS  PubMed  Google Scholar 

  2. Phillips C, Rodriguez A, Mosquera-Miguel A et al (2009) D9S1120, a simple STR with a common Native American-specific allele: forensic optimization, locus characterization and allele frequency studies. Forens Sci Int Genet 3:7–13

    Article  Google Scholar 

  3. Yuasa I, Nakagawa M, Umetsu K et al (2008) Molecular basis of complement factor I (CFI) polymorphism: one of two polymorphic suballeles responsible for CFI A is Japanese-specific. J Hum Genet 53:1016–1021

    Article  CAS  PubMed  Google Scholar 

  4. Bär W, Brinkmann B, Budowle B et al (1997) DNA recommendations. Further report of the DNA Commission of the ISFH regarding the use of short tandem repeat systems. Int J Legal Med 110:175–176

    Article  PubMed  Google Scholar 

  5. Excoffier L, Laval G, Schneider S (2005) Arlequin ver 3.0: an integrated software package for population genetics data analysis. Evol Bioinform Online 1:47–50

    CAS  PubMed  Google Scholar 

  6. Hartl DL, Clark AG (1997) Principles of population genetics, 3rd edn. Sinauer, Sunderland, MA

    Google Scholar 

  7. Handley LJL, Manica A, Goudet J, Balloux F (2007) Going the distance: human population genetics in a clinal world. Trends Genet 23:432–439

    Article  CAS  PubMed  Google Scholar 

  8. Keinan A, Mullikin JC, Patterson N, Reich D (2007) Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans. Nat Genet 39:1251–1255

    Article  CAS  PubMed  Google Scholar 

  9. Griffiths RA, Barber MD, Johnson PE et al (1998) New reference allelic ladders to improve allelic designation in a multiplex STR system. Int J Legal Med 111:267–272

    Article  CAS  PubMed  Google Scholar 

  10. Butler JM et al (2005) Forensic DNA typing. Biology, technology, and genetics of STR markers. Elsevier, Amsterdam

    Google Scholar 

  11. Montelius K, Karlsson AO, Holmlund G (2008) STR data for the AmpFlSTR Identifiler loci from Swedish population in comparison to European, as well as with non-European population. Forensic Sci Int Genet 2:e49–52

    Article  PubMed  Google Scholar 

  12. Hohoff C, Schürenkamp M, Brinkmann B (2009) Meiosis study in a population sample from Nigeria: allele frequencies and mutation rates of 16 STR loci. Int J Legal Med 123:259–261

    Google Scholar 

  13. Grubwieser P, Zimmermann B, Niederstätter H, Pavlic M, Steinlechner M, Parson W (2007) Evaluation of an extended set of 15 candidate STR loci for paternity and kinship analysis in an Austrian population sample. Int J Legal Med 121:85–89

    Article  CAS  PubMed  Google Scholar 

  14. Hering S, Augustin C, Edelmann J, Heidel M, Chamaon K, Dressler J, Szibor R (2008) Complex variability of intron 40 of the von Willebrand factor (vWF) gene. Int J Legal Med 122:67–71

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This study was supported in part by a Grant-in-Aid for Scientific Research (20590678 to IY) from the Japan Society for the Promotion of Science.

Author information

Authors and Affiliations

  1. Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago, 683-8503, Japan

    Isao Yuasa & Yoshito Irizawa

  2. Division of Legal Medicine, Ehime University School of Medicine, Ehime, Japan

    Hiroaki Nishimukai

  3. Osaka Red Cross Blood Center, Osaka, Japan

    Yasuo Fukumori

  4. Department of Experimental and Forensic Pathology, Faculty of Medicine, Yamagata University, Yamagata, Japan

    Kazuo Umetsu

  5. Department of Legal Medicine, Iwate Medical University School of Medicine, Morioka, Japan

    Nori Nakayashiki

  6. Division of Population Genetics, National Institute of Genetics, Mishima, Japan

    Naruya Saitou

  7. Institut für Blutgruppenforschung, Cologne, Germany

    Lotte Henke & Jürgen Henke

Authors
  1. Isao Yuasa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yoshito Irizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiroaki Nishimukai
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yasuo Fukumori
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kazuo Umetsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nori Nakayashiki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Naruya Saitou
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Lotte Henke
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Jürgen Henke
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Isao Yuasa.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Table S1

Allele nomenclature, fragment length, and repeat composition of 113 PCR fragments (alleles 16-55.3) (DOC 44 kb)

Table S2

Comparison of nucleotide sequence in STR and its flanking regions (DOC 31 kb)

Table S3

Distribution of allele frequencies for SNPs and STR in the CFI gene and parameters of forensic interest (DOC 31 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yuasa, I., Irizawa, Y., Nishimukai, H. et al. A hypervariable STR polymorphism in the complement factor I (CFI) gene: Asian-specific alleles. Int J Legal Med 125, 121–125 (2011). https://doi.org/10.1007/s00414-009-0369-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00414-009-0369-0

Keywords

Search

Navigation