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Expression of epidermal growth factor receptor in the inverted papilloma and squamous cell carcinoma of nasal cavity

  • Rhinology
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Abstract

The present study was undertaken to compare positive rate of immunostaining (PR) and positive intensity of immunostaining (PI) of epidermal growth factor receptor (EGFR) in inverted papilloma (IP), synchronous carcinoma with IP and metachronous carcinoma with IP of the nasal cavity. Ten subjects with nasal polyps, ten subjects with inverted papilloma (IP), five subjects with synchronous carcinoma with IP and ten subjects with metachronous carcinoma with IP were enrolled with a control group of ten subjects of inferior turbinate. Each specimen was divided into two portions: one for RNA isolation and the other for detection of EGFR protein. Positive rate of immunostaining, positive intensity of immunostaining for EGFR protein and EGFR mRNA were significantly up-regulated in the IP, synchronous carcinoma with IP and metachronous carcinoma with IP when comparing polyp and normal mucosa. A role for EGFR in the malignant transformation from IP to SCC of the nasal cavity is suggested.

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Acknowledgments

The authors would like to thank the Taiwan national Science Council for financial support (grant NSC 95-2314-B-006-017), and Professor. Ying-Tai Jin (Department of Pathology, National Cheng Kung University) for pathological assistance.

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Authors and Affiliations

  1. Department of Otolaryngology, National Cheng Kung University Hospital, No. 138, Sheng Li Road, Tainan, 704, Taiwan

    Jiung-Chih Chao & Sheen-Yie Fang

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  1. Jiung-Chih Chao
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  2. Sheen-Yie Fang
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Correspondence to Sheen-Yie Fang.

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Chao, JC., Fang, SY. Expression of epidermal growth factor receptor in the inverted papilloma and squamous cell carcinoma of nasal cavity. Eur Arch Otorhinolaryngol 265, 917–922 (2008). https://doi.org/10.1007/s00405-008-0582-3

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  • DOI: https://doi.org/10.1007/s00405-008-0582-3

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