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Cervical and oral teratoma in the fetus: a systematic review of etiology, pathology, diagnosis, treatment and prognosis

  • Materno-fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

The aim of the study was to produce a systematic review about etiology, pathology, diagnosis, prognosis and clinical management regarding oral and cervical teratomas.

Materials and methods

A systematic review of Pubmed/Medline using the following keywords was made: epignathus, cervical teratoma, fetus, oral teratoma, prenatal diagnosis, prognosis, treatment, ultrasound.

Conclusion

The following clinical conclusions can be reached: (1) teratomas are rare, usually benign congenital tumors which recognized multifactorial etiology; (2) prenatal ultrasound diagnosis can be made early in pregnancy (15–16 weeks); (3) 3D ultrasound and MRI may enhance the accuracy of the antenatal diagnosis (location, extension and intracranial spread) and may aid in the selection of patients requiring treatment; (4) prenatal karyotype and search for associated abnormalities is mandatory in all teratomas; (5) delivery should involve elective Cesarean section with ex utero intrapartum treatment procedure or resection of the tumor mass, which may be performed on placental support operation on placental support procedure to increase the chances of postnatal survival.

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Authors and Affiliations

  1. Prenatal Diagnostic Service, Prenatal Diagnostic Unit, Division of Obstetrics and Gynecology, Guastalla Civil Hospital, AUSL Reggio Emilia, Via Donatori Sangue, 1, 42016, Guastalla (Reggio Emilia), Italy

    Gabriele Tonni

  2. Neonatal Intensive Care Unit, Policlinic Hospital “Le Scotte”, University of Siena, Siena, Italy

    C. De Felice

  3. Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology, Policlinic Hospital “Le Scotte”, University of Siena, Siena, Italy

    G. Centini

  4. Human Pathology and Oncology, Pathologic Anatomy Section, Policlinic Hospital “Le Scotte”, University of Siena, Siena, Italy

    C. Ginanneschi

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  1. Gabriele Tonni
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  2. C. De Felice
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  3. G. Centini
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  4. C. Ginanneschi
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Correspondence to Gabriele Tonni.

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Tonni, G., De Felice, C., Centini, G. et al. Cervical and oral teratoma in the fetus: a systematic review of etiology, pathology, diagnosis, treatment and prognosis. Arch Gynecol Obstet 282, 355–361 (2010). https://doi.org/10.1007/s00404-010-1500-7

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  • DOI: https://doi.org/10.1007/s00404-010-1500-7

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