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Association of haptoglobin phenotypes with the development of Kaposi’s sarcoma in HIV patients

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Abstract

Kaposi’s sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by a genetic polymorphism leading to three major phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2). This study investigated the influence of Hp genetic polymorphism on the development of KS in HIV-positive patients. 661 HIV patients were enrolled in the study with a median age of 35 years and a median follow-up time of 57 months. Hp phenotyping was performed using hemoglobin-supplemented starch gel electrophoresis. In case of low Hp concentration high pressure gel permeation chromatography (HPGPC) was used. The Hp 1-1 phenotype was associated with a significant higher risk of KS compared to the combined group of Hp 2-1 and Hp 2-2 patients (p < 0.0005) which remained significant after adjustment for possible confounding variables (age, gender and AIDS status) (p < 0.001). In contrast, the Hp 2-1 phenotype carried the lowest risk. These findings point to the involvement of Hp phenotypes in the pathogenesis of KS, which may be due to a difference in skin immunosurveillance between the Hp phenotypes.

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Authors and Affiliations

  1. Department of Dermatology, Ghent University Hospital, Ghent, Belgium

    Reinhart Speeckaert & Lieve Brochez

  2. Institute for Tropical Medicine, Antwerp University Hospital, Antwerp, Belgium

    Bob Colebunders

  3. Department of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge, Bruges, Belgium

    Johan R. Boelaert

  4. Department of Clinical Chemistry, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium

    Jos Van Acker, Filip Van Wanzeele, Marijn M. Speeckaert, Chris Verhofstede, Marc De Buyzere, Jean Plum & Joris R. Delanghe

  5. Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg

    Robert Hemmer & Vic Arendt

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  1. Reinhart Speeckaert
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Correspondence to Joris R. Delanghe.

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Speeckaert, R., Colebunders, B., Boelaert, J.R. et al. Association of haptoglobin phenotypes with the development of Kaposi’s sarcoma in HIV patients. Arch Dermatol Res 303, 763–769 (2011). https://doi.org/10.1007/s00403-011-1161-9

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  • DOI: https://doi.org/10.1007/s00403-011-1161-9

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