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Association of HLA loci alleles and antigens in Saudi patients with vitiligo

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Abstract

HLA complex is composed of several closely linked loci, each containing several alleles, yielding a high expression of polymorphism. Vitiligo, a commonly acquired dermatological disorder, has been associated with different HLA antigens in different ethnic groups. In this study, HLA classes I (HLA-A, B, and C) and II (HLA-DR, DQ) antigens/alleles were analyzed in a group of 80 Saudi subjects consisting of vitiligo patients (40) and matched controls (40). The frequency of antigens of various HLA loci was tested using two-stage microcytotoxicity assays, while the frequency of alleles of HLA-DR was screened by polymerase chain reaction/sequence specific primers (PCR/SSP) method. The frequencies of HLA-B7, B15, Bw6, Cw6, Cw7, and DRB4*010101 were found to be significantly higher in vitiligo patients compared to controls [P = 0.029, 0.015, 0.033, 0.009, 0.043, and 0.015, respectively, with relative risk (RR) ≥ 3, etiologic fraction (EF) ≥ 0.4]. On the other hand, HLA-A9, B5, DQ1, and DRB3*010101 were significantly decreased in vitiligo patients compared to healthy Saudis [P = 0.008, 0.004, 0.028, and 0.04, respectively, with RR < 1 and preventive fraction (PF) < 0.5]. Among the patients, the highest allele frequency was noted for DRB4*010101(70%), while in controls it was for DRB3*010101 (72.5%). These results for antigens and allele frequency of various HLA Loci in vitiligo patients and control subjects suggested that HLA-B7, Bw6, Cw6, Cw7, and DRB4*010101 could be susceptible to vitiligo, while HLA-A9, B5, DQ1, and DRB3*010101 might be negatively associated with the development of vitiligo in Saudis.

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Authors and Affiliations

  1. Department of Dermatology, Armed Forces Hospital, P. O. Box 7897 (W 912), Riyadh, 11159, Saudi Arabia

    Abdullah Abanmi, Fahad Al Harthi, Riyadh Al Baqami, Saleh Al Assaf, Abdulrahman Zouman, Misbahul Arfin & Mohammad Tariq

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  1. Abdullah Abanmi
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  2. Fahad Al Harthi
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  3. Riyadh Al Baqami
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Correspondence to Mohammad Tariq.

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Abanmi, A., Harthi, F.A., Baqami, R.A. et al. Association of HLA loci alleles and antigens in Saudi patients with vitiligo. Arch Dermatol Res 298, 347–352 (2007). https://doi.org/10.1007/s00403-006-0699-4

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  • DOI: https://doi.org/10.1007/s00403-006-0699-4

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