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Calcium phosphate bone cement: a possible alternative to autologous bone graft. A radiological and biomechanical comparison in rat tibial bone

  • Orthopaedic Surgery
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Background

Donor site morbidity is a problem after autologous bone transplantation. An injectable CaP bone cement indicates properties similar to bone.

Materials and methods

Double osteotomies on rat tibias were performed. The intercalated segments were avascular (10), vascular (10), or avascular with Norian SRS® CaP bone cement replacing cancellous bone (10). Controls were non-operated contralateral tibias (15). All osteotomies were stabilised with an intra-medullary nail. After 8 weeks, all rats were killed. The harvested tibias were compared using X-ray, DEXA scanning, microCT scans and a biomechanical torsional test.

Results

No difference in healing processes or biomechanical results has been found between the avascular bone graft, vascular bone graft and CaP bone cement groups.

Conclusion

The injectable CaP bone cement confirms its similarities to bone, implying that it can be used as an adjunct to secure bone fragments and as a possible alternative to autologous bone transplantation in clinical practice.

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Acknowledgments

Our acknowledgements go to Hong Qu (Chief Engineer, Centre for Molecular biology and neuroscience, Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo), Dr Ragnhild Gunderson (Department of Radiology, Rikshospitalet, Oslo University Hospital), Dr Ulf E.W. Sigurdsen (Department of Orthopaedics, Akershus University Hospital), Per Ludvigsen (Engineer, Biomechanics Laboratory, Rikshospitalet, Oslo University Hospital), and The Department of Comparative Medicine (Rikshospitalet, Oslo University Hospital).

Conflict of interest

The authors confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannveien 20, 0027, Oslo, Norway

    Mona I. Winge, Olav Reikerås & Magne Røkkum

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  1. Mona I. Winge
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  2. Olav Reikerås
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  3. Magne Røkkum
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Correspondence to Mona I. Winge.

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Winge, M.I., Reikerås, O. & Røkkum, M. Calcium phosphate bone cement: a possible alternative to autologous bone graft. A radiological and biomechanical comparison in rat tibial bone. Arch Orthop Trauma Surg 131, 1035–1041 (2011). https://doi.org/10.1007/s00402-011-1271-z

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  • DOI: https://doi.org/10.1007/s00402-011-1271-z

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