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Comparison of the thermodynamic properties of structurally related amphiphilic antidepressants in aqueous solution

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Abstract

 The critical concentrations of amitriptyline, desipramine and nortriptyline hydrochlorides in aqueous solution were determined over the temperature range 288–313 K by a method based on deconvolution into Gaussians of the second derivate of the measured specific conductivity data. The mass-action model was used to calculate the thermodynamic quantities: standard free Gibbs energy, standard enthalpy and standard entropy of aggregate formation. The results are discussed in terms of the structure of the drug aggregates.

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Authors and Affiliations

  1. Grupo de Física de Coloides y Polímeros Departamento de Física de la Materia Condensada y Departamento de Física Aplicada, Facultad de Física Universidad de Santiago de Compostela 15706 Santiago de Compostela Spain e-mail: fmvictor@usc.es Tel.: +34-981-563100 Fax: +34-981-520676, , , , , , ES

    P. Taboada, J. M. Ruso, M. García & V. Mosquera

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  1. P. Taboada
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  2. J. M. Ruso
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  3. M. García
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  4. V. Mosquera
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Received: 12 June 2000 / in revised form: 10 October 2000 Accepted: 16 October 2000

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Taboada, P., Ruso, J., García, M. et al. Comparison of the thermodynamic properties of structurally related amphiphilic antidepressants in aqueous solution. Colloid Polym Sci 279, 716–720 (2001). https://doi.org/10.1007/s003960100495

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  • DOI: https://doi.org/10.1007/s003960100495

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