Abstract
The systemic disorder of mineral and bone metabolism which is related to chronic kidney disease (CKD) is called mineral and bone disorder (MBD). Calcifications related to CKD-MBD may occur in ophthalmic tissue, arterial walls, subcutaneous and periarticular soft tissues and organs. The vascular calcifications are the most important causes of mortality and morbidity in CKD. Here, we present a case of systemic lupus erythematosus with early and disseminated calcifications of vascular and periarticular soft tissues related to CKD-MBD.
Zusammenfassung
Die bei chronischer Nierenerkrankung (CKD, „chronic kidney disease“) auftretende systemische Störung des Mineral- und Knochenstoffwechsels wird als MBD („mineral and bone disorder“) bezeichnet. Verkalkungen im Zusammenhang mit CKD-MBD können in okulären Geweben, arteriellen Gefäßwänden, subkutanen und periartikulären Weichgeweben sowie in Organen entstehen. Die Gefäßverkalkungen sind die Hauptgründe für Morbidität und Mortalität bei CKD. Im Beitrag vorgestellt wird ein an systemischem Lupus erythematosus erkrankter Patient mit früher, disseminierter, CKD-MBD-bezogener Kalzifikation von Gefäßen und periartikulärem Weichgewebe.
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References
Moe SM, Drüeke T, Lameire N, Eknoyan G (2007) Chronic kidney disease-mineral-bone disorder: a new paradigm. Adv Chronic Kidney Dis 14:3–12
Asanuma Y, Oeser A, Shintani AK et al (2003) Premature coronary-artery atherosclerosis in systemic lupus erythematosus. N Engl J Med 349:2407–2415
Murphey MD, Sartoris DJ, Quale JL et al (1993) Musculoskeletal manifestations of chronic renal insufficiency. Radiographics 13:357–379
Bellasi A, Raggi P (2012) Vascular imaging in chronic kidney disease. Curr Opin Nephrol Hypertens 21:382–388
Imai N, Nagasawa M, Kimura K (2012) Severe calcification of the arteries. Intern Med 51:1445
Resić H, Masnić F, Ajanović S et al (2011) Non invasive evaluation of vascular calcifications in patients on hemodyalisis. Acta Med Croatica 65:24–29
K/DOQI Workgroup (2005) K/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients. Am J Kidney Dis 45:S1–S153
Milliner DS, Zinsmeister AR, Lieberman E, Landing B (1990) Soft tissue calcification in pediatric patients with end-stage renal disease. Kidney Int 38:931–936
McCullough PA, Sandberg KR, Dumler F, Yanez JE (2004) Determinants of coronary vascular calcification in patients with chronic kidney disease and end-stage renal disease: a systematic review. J Nephrol 17:205–215
Levey AS, Beto JA, Coronado BE et al (1998) Controlling the epidemic of cardiovascular disease in chronic renal disease: what do we know? What do we need to learn? Where do we go from here? National Kidney Foundation Task Force on Cardiovascular Disease. Am J Kidney Dis 32:853–906
O’Neill WC, Lomashvili KA, Malluche HH et al (2011) Treatment with pyrophosphate inhibits uremic vascular calcification. Kidney Int 79:512–517
Budisavljevic MN, Cheek D, Ploth DW (1996) Calciphylaxis in chronic renal failure. J Am Soc Nephrol 7:978–982
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Conflict of interest. F. Yıldız, B. Kelle, D.A. Taş, B. Kaya, E. Altun, and E. Erken state that there are no conflicts of interest.
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Yıldız, F., Kelle, B., Taş, D. et al. Diffuse soft tissue and vascular calcification in systemic lupus erythematosus with chronic kidney disease. Z. Rheumatol. 73, 754–757 (2014). https://doi.org/10.1007/s00393-014-1355-6
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DOI: https://doi.org/10.1007/s00393-014-1355-6