Abstract
Hepatobiliary cystadenoma is a rare hepatic neoplasm that has been reported only 10 times in the pediatric population. Although considered a benign cystic tumor of the liver, hepatobiliary cystadenoma has a high risk of recurrence with incomplete excision and a potential risk for malignant degeneration. Complete tumor excision with negative margins is the mainstay in treatment. Unfortunately, due to the paucity of cases and its vague presentation, hepatobiliary cystadenoma is rarely diagnosed preoperatively. Therefore, in patients with hepatic cystic masses without a clear diagnosis, total resection of the lesion with negative margins is indicated to adequately evaluate for malignant potential and limit the risk of recurrence. We describe a 2-year-old girl with an asymptomatic abdominal mass that was found to be hepatobiliary cystadenoma. In addition, the pathogenic, histopathologic and clinical features of hepatobiliary cystadenoma are reviewed.
This is a preview of subscription content, log in via an institution to check access.
References
Edmondson HA (1958) Tumors of the liver and intrahepatic bile ducts. Washington DC, Armed Forces Institute of Pathology (sect VII, fascicle 25)
Gadzijev E, Ferlan-Marolt V, Grkman J (1996) Hepatobiliary cystadenoma and cystadenocarcinoma. Report of five cases. HPB Surg 9:83–92
Senyuz OF, Numan F, Eroglu E et al (2004) Hepatobiliary mucinous cystadenoma in a child. J Pediatr Surg 39:E6–E8
Devaney K, Goodman ZD, Ishak KG (1994) Hepatobiliary cystadenoma and cystadenocarcinoma: a light microscopic and immunohistochemical study of 70 patients. Am J Surg Pathol 18:1078–1091
Alexander RC (1925) Solitary non-parasitic cysts of the liver. Edinburgh Med J 32:61
Wikle HT, Charache H (1936) Solitary nonparasitic cyst of the liver. Report of a case. Am J Surg 31:345–350
Forrest ME, Cho KJ, Shields JJ et al (1980) Biliary cystadenomas: sonographic-angiographic-pathologic correlations. Am J Radiol 135:723–727
Beasley SW, de Campo M, Chow CW et al (1986) Biliary cystadenoma in a young child. Pediatr Surg Int 1:72–73
Williams JG, Newman BM, Sutphen JL et al (1990) Hepatobiliary cystadenoma: a rare hepatic tumor in a child. J Pediatr Surg 25:1250–1252
Cacciaguerra S, Lucenti A, Vasta G et al (1996) Hepatobiliary cystadenoma with hyaline stroma: a pediatric case associated with multiple hemangiomas. Pediatr Surg Int 11:380–383
Wood JA, McLeary MS, Thomas RD et al (1998) Biliary cystadenoma in a child: CT and MR appearances. Pediatr Radiol 28:922
Blanchard SS, Price S, Nakamoto D et al (2003) A rare cause of cholestatic jaundice in teenager: biliary cystadenoma. Am J Gastroenterol 98:S141
Marrone G, Maggiore G, Carollo V et al (2011) Biliary cystadenoma with bile duct communication depicted on liver-specific contrast agent-enhanced MRI in a child. Pediatr Radiol 41:121–124
Akwari OE, Tucker A, Seigler HF et al (1990) Hepatobiliary cystadenoma with mesenchymal stroma. Ann Surg 211:18–27
Adeyiga AO, Lee EY, Eisenberg RL (2012) Focal hepatic masses in pediatric patients. Am J Roentgenol 199:W422–W440
Ishak KG, Wills GW, Cummins SD et al (1977) Biliary cystadenoma and cystadenocarcinoma: report of 14 cases and review of the literature. Cancer 38:322–338
Conflict of interest
The authors cite no personal conflicts of interest or financial arrangements with the organizations, corporations, and/or devices detailed in this manuscript. No sources of external funding were utilized.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tran, S., Berman, L., Wadhwani, N.R. et al. Hepatobiliary cystadenoma: a rare pediatric tumor. Pediatr Surg Int 29, 841–845 (2013). https://doi.org/10.1007/s00383-013-3290-z
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00383-013-3290-z