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Elevated serum alpha-fetoprotein in Wilms tumor may follow the same pattern of other fetal neoplasms after treatment: evidence from three cases

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Abstract

Alpha-fetoprotein (AFP) is a common tumoral marker in pediatric neoplasms; increased serum levels are usually encountered in tumors arising from tissues producing AFP during fetal life. However, elevation of such protein is rarely found in patients with Wilms tumor (WT). Three patients with WT and elevated serum AFP were studied over the course of the disease. One patient had left WT with invasion of aorto-caval lymph nodes and lung metastases. The second patient was referred to our center for abdominal recurrence of bilateral WT whereas the third showed right WT with inferior vena cava thrombosis. AFP levels demonstrated a trend parallel to decrease/increase of tumor size, with further elevation in patients with metastases. Elevated AFP serum levels in patients with WT could be related to peculiar histological features and serial dosage might be a useful diagnostic and prognostic test.

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Authors and Affiliations

  1. Operative Unit of General and Thoracic Surgery, Bambino Gesù Children Hospital, Piazza di S.Onofrio 4, 00165, Rome, Italy

    A. Crocoli, S. Madafferi & A. Inserra

  2. Operative Unit of Oncology, Bambino Gesù Children Hospital, Piazza di S.Onofrio 4, 00165, Rome, Italy

    A. Jenkner

  3. Operative Unit of Urodynamics and Nephro-Urology, Bambino Gesù Children Hospital, Piazza di S.Onofrio 4, 00165, Rome, Italy

    A. Zaccara

Authors
  1. A. Crocoli
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  2. S. Madafferi
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  3. A. Jenkner
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  4. A. Zaccara
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  5. A. Inserra
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Correspondence to A. Crocoli.

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Crocoli, A., Madafferi, S., Jenkner, A. et al. Elevated serum alpha-fetoprotein in Wilms tumor may follow the same pattern of other fetal neoplasms after treatment: evidence from three cases . Pediatr Surg Int 24, 499–502 (2008). https://doi.org/10.1007/s00383-007-2067-7

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  • DOI: https://doi.org/10.1007/s00383-007-2067-7

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