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Augenärztliches Screening bei Frühgeborenen

Ophthalmological screening for retinopathy of prematurity

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Zusammenfassung

Die Frühgeborenenretinopathie zählt in der Kindheit in den Industrienationen zu den 3 häufigsten Ursachen einer Erblindung nach dem Gesetz. Ein adäquates augenärztliches Screening stellt eine wesentliche Voraussetzung für die Möglichkeit einer erfolgreichen Therapie der Erkrankung dar. International und national wurden in den letzten Jahren und Jahrzehnten immer wieder Richtlinien zum augenärztlichen Screening Frühgeborener aktualisiert. Die Empfehlungen stehen dabei in direktem Zusammenhang mit den Entwicklungen der Neonatologie, dem Überleben immer unreiferer Kinder auf der einen Seite und dem verbesserten Wissen über Zusammenhänge zwischen verschiedenen neonatologischen Parametern und deren gezieltem Einfluss auf das Risiko der Entwicklung einer Frühgeborenenretinopathie andererseits. Die vorliegende Arbeit gibt einen Überblick über die Klassifikation der Frühgeborenenretinopathie, über einen Vergleich der nationalen und internationalen Empfehlungen zum Screening sowie über neuere Aspekte des Screenings anhand neonatologischer Daten.

Abstract

Retinopathy of prematurity (ROP) is one of the three leading causes of legal blindness in childhood in developed countries. Adequate screening is one of the most important steps towards successful treatment. During the last decades, international and national guidelines for ROP screening have been continually updated. These guidelines correspond to progress in neonatal care and to a better understanding of the relationship between different neonatal parameters and the risk of developing ROP. The present article surveys ROP classification, the current national and international guidelines and new aspects of ROP screening.

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Literatur

  1. An International Committee for the Classification of Retinopathy of Prematurity (2005) The international classification of retinopathy of prematurity revisited. Arch Ophthalmol 123:991–999

    Article  Google Scholar 

  2. An International Committee for the Classification of Retinopathy of Prematurity (1984) An international classification of retinopathy of prematurity. Br J Ophthalmol 68:690–697

    Article  Google Scholar 

  3. Brennan R, Gnanaraj L, Cottrell DG (2003) Retinopathy of prematurity in practice. I: screening for threshold disease. Eye 17:183–188

    Article  PubMed  CAS  Google Scholar 

  4. Chiang MF, Wang L, Busuioc M et al (2008) Telemedical retinopathy of prematurity diagnosis: accuracy, reliability, and image quality. Arch Ophthalmol 125(1):1531–1538

    Article  Google Scholar 

  5. Cryotherapy for Retinopathy of Prematurity Cooperative Group (1988) Multicenter trial of cryotherapy for retinopathy of prematurity. Preliminary results. Arch Ophthalmol 106:471–479

    Article  Google Scholar 

  6. Gallagher K, Moseley M, Tandon A et al (2003) Asymmetric location of retinopathy of prematurity in the nasal and temporal retina. Arch Ophthalmol 121:1563–1568

    Article  PubMed  Google Scholar 

  7. Hellgren G, Willett K, EngstromE et al (2010) Proliferative retinopathy is associated with impaired increase in BDNF and RANTES expression levels after preterm birth. Neonatology 98:409–418

    Article  PubMed  CAS  Google Scholar 

  8. Hughes S, Yang H, Chan-Ling T (2000) Vascularizaton of the human fetal retina: roles of vasculogenesis and angiogenesis. Invest Ophthalmol Vis Sci 41:1217–1228

    PubMed  CAS  Google Scholar 

  9. Jandeck C, Kellner U, Heimann H et al (2005) Frühgeborenenretinopathie-Screening: Ergebnisse eines Zentrums zwischen 1991 und 2002. Klin Monatsbl Augenheilkd 222:577–585

    Article  PubMed  CAS  Google Scholar 

  10. Jandeck C, Kellner U, Lorenz B, Seiberth V (2008) Leitlinie zur augenärztlichen Screening-Untersuchung von Frühgeborenen. Ophthalmologe 105:955–964

    Article  PubMed  CAS  Google Scholar 

  11. Löfquist C, Andersson E, Sigurdsson J et al (2006) Longitudinal postnatal weight and insulin-like growth factor I measurements in the prediction of retinopathy of prematurity [published correction appears in Arch Ophthalmol 125(3):426]. Arch Ophthalmol 124(12):1711–1718

    Article  Google Scholar 

  12. Löfquist C, Hansen-Pupp I, Andersson E et al (2009) Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I. Arch Ophthalmol 127(5):622–627

    Article  Google Scholar 

  13. Lorenz B (2008) Aktuelle augenärztliche Aspekte der akuten Retinopathia praematurorum. Ophthalmologe 105:1092–1100

    Article  PubMed  CAS  Google Scholar 

  14. Mintz-Hittner HA, Kennedy KA, Chuang AZ, fort he BEAT-ROP Cooperative Group (2011) Efficacy of ntravitreal Bevacizumab for Stage 3+ retinopathy of prematurity. N Engl J Med 364(7):603–615

    Article  PubMed  CAS  Google Scholar 

  15. Morizane H (1976) Initial sign an clinical course of the most severe form of acute proliferative retrolental fibroplasias (type II) (in Japanese). Nippon Ganka Gakkai Zasshi 80:54–61

    PubMed  CAS  Google Scholar 

  16. Palmer EA, Flynn JT, Hardy RJ et al (1991) The cryotherapy for retinopathy of prematurity cooperative group. Incidence and early course of retinopathy of prematurity. Ophthalmology 98:1628–1640

    PubMed  CAS  Google Scholar 

  17. Schiariti V, Matsuba C, Hoube JS, Synnes AR (2008) Severe retinopathy of prematurity and visual outcomes in British Columbia: a 10-year analysis. J Perinatol 28(8):566–572

    Article  PubMed  CAS  Google Scholar 

  18. Slidsborg C, Olesen HB, Jensen PK et al (2008) Treatment for retinopathy of prematurity in Denmark in a ten-year period (1996–2005): Is the incidence increasing? Pediatrics 121(1):97–105

    Article  PubMed  Google Scholar 

  19. Soejima N, Takagi I, Takashima Y (1976) Clinical studies on retinopathy of prematurity, severe and rapidly progressive type. Folia Ophthalmol Jpn 27:155–161

    Google Scholar 

  20. (2012) Stellungnahme der Deutschen Ophthalmologischen Gesellschaft, der Retinologischen Gesellschaft und des Berufsverbands der Augenärzte Deutschlands zum Einsatz von Bevacizumab in der Therapie der Frühgeborenenretinopathie; Stand 20.12.2011. Ophthalmologe 109(2):197–204

  21. The Committee for the Classification of Retinopathy of Prematurity (1984) An international classification of retinopathy of prematurity. Arch Ophthalmol 102:1130–1134

    Article  Google Scholar 

  22. The Early Treatment for Retinopathy of Prematurity Cooperative Group (2003) Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 121(12):1684–1696

    Article  Google Scholar 

  23. The Early Treatment for Retinopathy of Prematurity Cooperative Group (2006) The early treatment for retinopathy of prematurity study: structural findings at age 2 years. Br J Ophthalmol 90:1378–1382

    Article  Google Scholar 

  24. The International Committee for the Classification of Late Stages of Retinopathy of Prematurity (1987) An international classification of retinopathy of prematurity: II. The classification of retinal detachment. Arch Ophthalmol 105:906–912

    Article  Google Scholar 

  25. The STOP-ROP Multicenter Study Group (2000) Supplemental therapeutic oxygen for prethreshold retinopathy of prematurity (STOP-ROP): a randomized, controlled trial, I: primary outcomes. Pediatrics 105:295–310

    Article  Google Scholar 

  26. Uemura Y, Tsukahara I, Nagata M et al (1974) Diagnostic and therapeutic criteria for retinopathy of prematurity. Committee’s report appointed by the Japanese Ministry of Health and Welfare. Japanese Ministry of health and Welfare, Tokyo

  27. Wallace DK, Quinn GE, Freedman SF et al (2008) Agreement among pediatric ophthalmologists in diagnosing plus and pre-plus disease in retinopathy of prematurity. J AAPOS 12(4):352–356

    Article  PubMed  Google Scholar 

  28. Wikstrand MH, Hard A-L, Niklasson A et al (2011) Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity. Acta Paediatr 100:1528–1533

    Article  PubMed  Google Scholar 

  29. Wu C, Van der Veen DK, Hellström A et al (2010) Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity. Arch Ophthalmol 128(4):443–447

    Article  PubMed  Google Scholar 

  30. Wu C, Löfquist C, Smith LEH et al. for the WINROP Consortium (2012) Importance of early postnatal weight gain for normal retinal angiogenesis in very preterm infants. Arch Ophthalmol 130(8):992–999

    Article  PubMed  Google Scholar 

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Correspondence to I. Oberacher-Velten.

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Oberacher-Velten, I., Segerer, H. & Helbig, H. Augenärztliches Screening bei Frühgeborenen. Ophthalmologe 109, 1182–1188 (2012). https://doi.org/10.1007/s00347-012-2617-9

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