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Multimodal, polypragmatisch und kostenintensiv

Rückenschmerzbehandlungen auf dem Prüfstand

Multimodal, polypragmatic, and very costly

Treatments for low back pain under review

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Zusammenfassung

Die angebotenen Therapien für Rückenschmerzen sind vielfältig, von singulären Interventionen bis hin zu komplexen chirurgischen Eingriffen und aufwendigen multimodalen Therapieprogrammen. Wie sieht es aber mit der aktuellen Evidenz aus? Ist alles, was teuer ist, auch effektiv? In diesem Review wird eine Übersicht über gängige Einzeltherapien und Komplexbehandlungen mit, soweit möglich, einer Kosten- und Evidenzanalyse gegeben. Aus der aktuellen Evidenz lässt sich insbesondere bei Patienten mit chronischen und chronifizierungsgefährdeten Rückenschmerzen die Notwendigkeit zur frühzeitigen multimodalen interdisziplinären Diagnostik ableiten. Monomodale Diagnostik- und Therapiekonzepte sind oft nicht zielführend. Weitere Forschung in Richtung Subgruppenbildung wäre sinnvoll, um gezielte Therapieprogramme zu ermöglichen. Diagnostische Bildgebung, interventionelle sowie operative Verfahren sollten mit einer größeren Zurückhaltung angewandt werden.

Abstract

There are many therapies for low back pain, from simple interventions up to complex surgical procedures and multimodal therapy programs. But what does the medical evidence say? Are expensive therapies worth the money they cost? This review gives an overview of frequently used interventions and complex therapy programs and as far as possible the medical evidence and costs. Reviewing the scientific evidence the need for early interdisciplinary multimodal diagnostics in patients with chronic low back pain becomes evident. Single interventions are often not indicated. Further research is needed to define subgroups for special treatment programs. Radiography, interventional pain therapies, and operations should be used with great care.

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Literatur

  1. Kendrick D, Fielding K, Bentley E et al (2001) Radiography of the lumbar spine in primary care patients with low back pain: randomised controlled trial. BMJ 322:400–405

    Article  PubMed  CAS  Google Scholar 

  2. Watson PJ, Main CJ, Waddel G (1998) Medically certified work loss, recurrence and costs of wage compensation for back pain: a follow up study of the working population of Jersey. Br J Rheumatol 37:82–86

    Article  PubMed  CAS  Google Scholar 

  3. Wenig CM, Schmidt CO, Kohlmann T, Schweikert B (2009) Costs of back pain in Germany. Eur J Pain 13:280–286

    Article  PubMed  Google Scholar 

  4. Juniper M, Le TK, Mladsi D (2009) The epidemiology, economic burden and pharmacological treatment of chronic low back pain in France, Germany, Italy, Spain and the UK: a literature-based review. Expert Opin Pharmacother 10(A6):2581–2592

    Article  PubMed  CAS  Google Scholar 

  5. Andersson GB (1999) Epidemiological features of chronic low back pain. Lancet 91(78):581–585

    Article  Google Scholar 

  6. Watson PJ, Main CJ, Waddel G et al (1998) Medicals certified work loss, recurrence and cost of wage compensation for back pain: a follow-up study of the working population of Jersey. Br J Rheumatol 37:82–86

    Article  PubMed  CAS  Google Scholar 

  7. Niemier K, Seidel W (2009) Funktionelle Schmerztherapie des Bewegungssystems. Springer, Berlin Heidelberg New York

  8. Hampton JR (1975) Relative contribution of history taking, physical examination and laboratory investigation to diagnosis and management of medical patients. BMJ 2:486–489

    Article  PubMed  CAS  Google Scholar 

  9. Peterson MC, Holbrook JH, Hales D von (1992) Contributions of the history, physical examination and laboratory investigations in making medical diagnoses. West J Med 156(2):163–165

    PubMed  CAS  Google Scholar 

  10. Deyo R, Mirza S, Turner Y (2009) Overtreating chronic back pain: time to back off? J Am Board Fam Med 22(1):62–68

    Article  PubMed  Google Scholar 

  11. Scavone JC, Latshaw RF, Rohrar GV (1981) Use of lumbar spine films: statistical evaluation at a teaching hospital. JAMA 246:1105–1108

    Article  PubMed  CAS  Google Scholar 

  12. Simmons ED, Guyer RG, Graham-Smith A et al (2003) Radiograph assessment for patients with low back pain. Spine J 3:3–5

    Article  Google Scholar 

  13. Chou R, Fu R, Carrino J et al (2009) Imaging strategies for low back pain: systematic review and meta-analysis. Lancet 373:463–472

    Article  PubMed  Google Scholar 

  14. Jarvic JG, Hollingworth W, Martin B et al (2003) Rapid magnetic resonance imaging vs. radiographs for patients with low back pain. JAMA 289:2810–2818

    Article  Google Scholar 

  15. Modic MT, Obuchowski NA, Ross JS et al (2005) Acute low back pain and radiculopathy: MR imaging findings and their prognostic role and effect on outcome. Radiology 237:597–604

    Article  PubMed  Google Scholar 

  16. Wiesel SW, Tsourmas N, Feffler HL et al (1984) A study of computer assisted tomography. The incidence of positive cat scans in an asymptomatic group of patients. Spine 9:549–551

    Article  PubMed  CAS  Google Scholar 

  17. Boden SD, McCowin PR, Davis DO et al (1990) Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am 72(8):1178–1184

    PubMed  CAS  Google Scholar 

  18. Maus T (2010) Imagin the back pain patient. Phys Med Rehabil Clin N Am 21:725–766

    Article  PubMed  Google Scholar 

  19. Jarvic JJ, Hollingworth W, Heagerty P et al (2001) The longitudinal assessment of imaging and disability of the back (LAID Back) study. Spine 26(10):1158–1166

    Article  Google Scholar 

  20. Niemier K, Seidel W, Pioch E, Werin A (2003) Sommerfeld assessment system: introduction and evaluation of a multiprofessional assessment system for the differential diagnosis of chronic musculoskeletal pain syndromes. JOM 25:21–26

    Google Scholar 

  21. El-Metwally A, Salminen JJ, Auvinen A (2004) Prognosis of non-specific musculoskeletal pain in preadolescents: a prospective 4-year follow-up study till adolescence. Pain 110(3):550–559

    Article  PubMed  Google Scholar 

  22. Radebold A, Cholewicki J, Polzhofer GK et al (2001) Impaired postural control of the lumbar spine is associated with delayed muscle response times in patients with low back pain. Spine 26:724–730

    Article  PubMed  CAS  Google Scholar 

  23. Pfingsten M, Franz C, Hildebrandt J et al (1996) Das Göttinger Rücken Intensiv Programm (GRIP) – ein multimodales Behandlungsprogramm für Patienten mit chronischen Rückenschmerzen, Teil 3. Psychosoziale Aspekte. Schmerz 10:326–344

    Article  PubMed  CAS  Google Scholar 

  24. Nguyen TH, Randolph DC, Talmage J et al (2011) Long-term outcomes of lumbar fusion among workers compensation subjects. Spine 36(4):320–331

    PubMed  Google Scholar 

  25. Webster BS, Verma S, Pransky GS (2004) Outcomes of workers compensation claimants with low back pain undergoing intradiscal electrothermal therapie. Spine 29(4):435–441

    Article  PubMed  Google Scholar 

  26. http://www.versorgungsleitlinien.de/themen/kreuzschmerz. Zugegriffen: 18.05.2011

  27. Niemier K, Ritz W, Amelung P, Seidel W (2007) Evaluierung der funktionellen muskuloskeletalen Diagnostik als Bestandteil eines multiprofessionellen Diagnostiksystems für Patienten mit chronischen und chronifizierungsgefährdeten Schmerzen des Bewegungssystems. Manuelle Med 45:123–127

    Article  Google Scholar 

  28. Fullen BM, Doody C, David Baxter G et al (2008) Chronic low back pain: non-clinical factors impacting on management by Irish doctors. Ir J Med Sci 177:257–263

    Article  PubMed  CAS  Google Scholar 

  29. Fullen BM, David Baxter G, O’Donnovan BGG et al (2008) Doctors attitudes and beliefs regarding acute low back pain management: a systematic review. Pain 136:388–396

    Article  PubMed  CAS  Google Scholar 

  30. Lang E, Eisele R, Kastner S et al (2000) Ergebnisqualität der ambulanten Versorgung von Patienten mit chronischen Rückenschmerzen. Schmerz 14:146–159

    Article  PubMed  CAS  Google Scholar 

  31. http://www.gkv-his.de. Zugegriffen: 25.02.2011

  32. Chou R, Huffman LH (2007) Medication for acute and chronic low back pain: a review of the evidence for an american pain society/american college of physicians clinical practice guideline. Ann Intern Med 147:505–514

    PubMed  Google Scholar 

  33. Hildebrand J (2001) Relevance of nerve blocks in treating and diagnosting low back pain – is the quality decisive? Schmerz 15(6):474–483

    Article  Google Scholar 

  34. Staal JB, Bie RA m de, Vet HCW de et al (2008) Injection therapy for subacute and chronic low back pain. Spine 34(1):49–59

    Article  Google Scholar 

  35. Slipman CW, Bhat AL, Gilchrist RV et al (2003) A critical review of the evidence for the use of zygapophysial injections and radiofrequency denervations in the treatment of low back pain. Spine J 3:310–316

    Article  PubMed  Google Scholar 

  36. Henschke N, Kuijpers T, Rubinstein SM et al (2010) Injection therapy and denervation procedures for chronic low-back pain: a systematic review. Eur Spine J 19:1425–1449

    Article  PubMed  Google Scholar 

  37. Kim WM, Lee HG, Jeong CW et al (2010) A randomized controlled trial of intra-articular prolotherapie versus steroid injection for sacroiliac joint pain. J Altern Complement Med 16(12):1285–1290

    Article  PubMed  Google Scholar 

  38. Gofeld M, Jiterenda J, Faclier G (2007) Radiofrequency denervation of the lumbar zygapophysial joints: 10 year prospective clinical audit. Pain Physician 10:291–299

    PubMed  Google Scholar 

  39. Wetzel FTR, McNally TA, Phillips FM (2002) Intradiscal electrothermal therapy used to manage chronic discogenic low back pain. New directions and interventions. Spine 27(22):2621–2626

    Article  PubMed  Google Scholar 

  40. Chao SC, Lee HT, Kao TH et al (2008) Percutaneous pulsed radiofrequency in the treatment of cervical and lumbar radicular pain. Surg Neurol 70:59–65

    Article  PubMed  Google Scholar 

  41. Kemler MA, Barendse GA, Kleef M van et al (2000) Spinal cord stimulation in patients with chronic reflex sympathetic dystrophy. N Engl J Med 343:618–624

    Article  PubMed  CAS  Google Scholar 

  42. North RB, Kidd DH, Farrhoki F et al (2005) Spinal cord stimulation versus repeated lumbosacral spine surgery for chronic pain: a randomized controlled trial. Neurosurgery 56:98–106

    PubMed  Google Scholar 

  43. Kumar K, Taylor RS, Jacques L et al (2007) Spinal cord stimulation versus conventional medical management for neuropathic pain: a multicenter randomised controlled trial in patients with failed back surgery syndrome. Pain 132:179–188

    Article  PubMed  Google Scholar 

  44. Bala MM, Riemsma RP, Nixon J, Kleijnen J (2008) Systematic review of the (cost-)effectiveness of spinal cord stimulation for people with failed back surgery syndrome. Clin J Pain 24(9)741–756

    Google Scholar 

  45. Deer T, Chapple I, Classen A et al (2004) Intrathecal drug delivery for the treatment of chronic low back pain: report from the national outcome registry for low back pain. Pain Med 5:6–13

    Article  PubMed  Google Scholar 

  46. Doleys DM, Brown JL, Ness T (2006) Multidimensional outcome analysis of intrathecal, oral opiod and behavioural-functional restoration therapy for failed back surgery syndrome: a retrospective study with four years follow-up. Neuromodulation 9:270–283

    Article  PubMed  Google Scholar 

  47. Saur P, Hildebrandt J, Pfingsten M et al (1996) Das Göttinger Rücken Intensiv Programm (GRIP) – ein multimodales Behandlungsprogramm für Patienten mit chronischen Rückenschmerzen, Teil 2. Somatische Aspekte. Schmerz 10: 237–253

    Article  PubMed  CAS  Google Scholar 

  48. Niemier K, Amelung P, Satorie S et al (2007) Kardio-pulmonale Dekonditionierung von Patienten mit chronischen Schmerzen des Bewegungssystems. Welcher Test ist für die Diagnostik und Therapieplanung geeignet? Phys Med Rehab Kuror 17:209–214

    Article  Google Scholar 

  49. Hodges PW, Richardson CA (1996) Inefficient muscular stabilization of the lumbar spine associated with low back pain. A motor control evaluation of the transverse abdominis. Spine 21(22):2640–2650

    Article  PubMed  CAS  Google Scholar 

  50. Niemier K, Ritz W, Seidel W (2007) Der Einfluss muskuloskeletaler Funktionsstörungen auf chronische Schmerzsyndrome des Bewegungssystems. Schmerz 21(2):139–145

    Article  PubMed  CAS  Google Scholar 

  51. Tulder M van, Malmivaara A, Esmail R, Koes B (2000) Exercise therapy for low back pain. A systematic review within the framework of the Cochrane collaboration back review group. Spine 25(21):2784–2796

    Article  PubMed  Google Scholar 

  52. Mannion AF, Müntener M, Tailela S, Dvorak J (2001) Comparison of three active therapies for chronic low back pain: results of a randomized clinical trial with one year follow up. Rheumatology (Oxford) 40:722–778

    Google Scholar 

  53. Ferreira PH, Ferreira ML, Maher CG et al (2006) Specific stabilization exercise for spinal an pelvic pain. Aust J Physiother 52:79–88

    Article  PubMed  Google Scholar 

  54. Fordyce WE (1976) Behavioral methods for chronic pain and illness. Mosby, St Louis

  55. Turner JA, Jensen MP (1993) Efficacy of cognitive therapy for chronic low back pain. Pain 52:169–177

    Article  PubMed  CAS  Google Scholar 

  56. Vlayen JW, Haazen IW, Schuermann JA et al (1995) Behavioural rehabilitation of chronic low back pain: comparison of an operant treatment, operant-cognitive treatment and an operant-respondent treatment. Br J Clin Psychol 34:95–118

    Article  Google Scholar 

  57. Tulder MW van, Ostelo R, Vlaeyen JWS et al (2000) Behavioural treatment for chronic low back pain. A systematic review within the framework of the Cochrane back review group. Spine 25(20):2688–2699

    Article  PubMed  Google Scholar 

  58. Liccardone JC, Brimhall A, King LN (2005) Osteopathic manipulative treatment for low back pain: a systematic review and meta-analysis of randomized controlled trials. BMC Musculoskelet Disord 6:43. Doi:10.1186/147-2474-6-43

    Article  Google Scholar 

  59. Bronfort G, Haas M, Evans RL, Bouter LM (2004) Efficacy of spinal manipulation and mobilization for low back pain and neck pain: a systematic review and best evidence synthesis. Spine J 4:335–356

    Article  PubMed  Google Scholar 

  60. Bronfort G, Assendelft WJJ, Evans R et al (2001) Efficacy of spinal manipulation for chronic headache: a systematic review. J Manipulative Physiol Ther 24(7):457–466

    PubMed  CAS  Google Scholar 

  61. Pioch E, Seidel W (2003) Manuelle Medizin bei chronischen Schmerzen. Evaluation eines stationären Behandlungskonzeptes. Schmerz 17:34–43

    Article  PubMed  CAS  Google Scholar 

  62. Blomberg S, Hallin G, Grann K et al (1994) Manual therapy with steroid injections – a new approach to treatment of low back pain. Spine 19(5):569–577

    Article  PubMed  CAS  Google Scholar 

  63. Furlan AD, Imamura M, Dryden T, Irvin E (2009) Massage for low back pain. An updated systematic review within the framework of the Cochrane back review group. Spine 34(16):1669–1684

    Article  PubMed  Google Scholar 

  64. Heymanns MW, Tulder MW van, Esmail R et al (2005) Back schools for nonspecific low back pain. A systematic review within the framework of the Cochrane collaboration back review group. Spine 30(19):2153–2163

    Article  Google Scholar 

  65. Chou R, Huffmann LH (2007) Nonpharmacological therapies for acute and chronic low back pain: a review of the evidence for an American pain society/American College of Physicians clinical practice guideline. Ann Intern Med 147:492–504

    PubMed  Google Scholar 

  66. Middelkoop M van, Rubinstein SM, Kuijpers T et al (2011) A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain. Eur Spine J 20:19–39

    Article  PubMed  Google Scholar 

  67. Brosseau LB, Milne S, Robinson V et al (2002) Efficacy of the transcutaneous electrical nerve stimulation for the treatment of chronic low back pain. Spine 27(6):596–603

    Article  PubMed  Google Scholar 

  68. Saper RB, Karen JS, Cullum-Dugan D et al (2009) Yoga for chronic low back pain in a predominantly minority population: a pilot randomized controlled trial. Altern Ther Health Med 15(6):18–27

    PubMed  Google Scholar 

  69. Shermann KJ, Chercin CC, Erro J et al (2005) Comparing yoga, exercise and a self-care book for chronic low back pain. A randomized, controlled trial. Ann Intern Med 143:849–856

    Google Scholar 

  70. http://www.gbe-bund.de/. Zugegriffen: 25.02.2011

  71. Hüppe A, Raspe H (2003) Die Wirksamkeit von stationärer medizinischer Rehabilitation in Deutschland bei chronischen Rückenschmerzen: eine systematische Literaturübersicht 1980–2001. Rehabilitation 42:143–154

    Article  PubMed  Google Scholar 

  72. Hüppe A, Raspe H (2005) Efficacy of inpatient rehabilitation for chronic low back pain in Germany: update of a systemic review. Rehabilitation 44(1):24–33

    Article  PubMed  Google Scholar 

  73. Merkesdal S, Mau W (2005) Prediction of cost-of-illness in patients with low back pain undergoing orthopeadic outpatient rehabilitation. Int J Rehabil Res 28(2):119–126

    Article  PubMed  Google Scholar 

  74. Cherkin CC, Deyo RA, Loeser JD (1994) An international comparison of back surgery rates. Spine 19(11):1201–1206

    PubMed  CAS  Google Scholar 

  75. Lurie JD, Birkmeyer NJ, Weinstein JN (2003) Rates of advanced spinal imaging and spine surgery. Spine 28:616–620

    PubMed  Google Scholar 

  76. Niethard U (2011) Für eine konservative Orthopädie und Unfallchirurgie. Orthopade 4(11):317–318

    Google Scholar 

  77. Fritzell PF, Hägg OH, Wessberg P et al (2001) Lumbar fusion vs. nonsurgical treatment for low back pain. A multicenter randomized controlled trial from the Swedish lumbar spine study. Volvo award in clinical studies. Spine 26:2521–2532

    Article  PubMed  CAS  Google Scholar 

  78. Brox JI, Sorensen R, Friis A et al (2003) Randomized clinical trial of lumbar instrumented fusion and cognitive intervention and exercises in patients with chronic low back pain and disc degeneration. Spine 28(17):1913–1921

    Article  PubMed  Google Scholar 

  79. Mirza SK, Deyo FA (2007) Systematic review of randomized trials comparing lumbar fusion surgery to nonoperative core for treatment of chronic back pain. Spine 32(7):816–823

    Article  PubMed  Google Scholar 

  80. Carreon LY, Glassman SD, Howard J (2008) Fusion and nonsurgical treatment for symptomatic degenerative disease: a systematic review of Ostwestry Disability Index and MOS short form-36 outcomes. Spine J 8:747–755

    Article  PubMed  Google Scholar 

  81. Atlas SJ, Keller RB, Chang YC et al (2001) Surgical and nonsurgical management of sciatica secondary to lumbar disc herniation: five years outcome from the main lumbar spine study. Spine 26(10):1179–1187

    Article  PubMed  CAS  Google Scholar 

  82. Atlas SJ, Keller RB, Chang YC et al (2005) Long term outcomes of surgical and nonsurgical management of sciatica secondary to lumbar disc herniation: 10 years results from the main lumbar spine study. Spine 30(8):927–935

    Article  PubMed  Google Scholar 

  83. Weber H (1983) Lumbar disk herniation. A controlled, prospective study with ten years of observation. Spine 8(2):131–140

    Article  PubMed  CAS  Google Scholar 

  84. Atlas SJ, Keller RB, Wu YA (2005) Long term outcomes of surgical and nonsurgical management of lumbar stenosis: 8–10 years results from the main lumbar spine study. Spine 30(8):936–9943

    Article  PubMed  Google Scholar 

  85. Rivero-Arias O, Campbell H, Gray A et al (2005) Surgical stabilisation of the spine compared with a programme of intensive rehabilitation for the management of patients with chronic low back pain: cost utility analysis based on a randomized controlled trial. BMJ. Doi:10.1136/bmj.38441.429618.BF

  86. Dimova V, Lautenbacher S (2010) Chronischer Schmerz nach Operationen. Epidemiologie unter besonderer Berücksichtigung psychologischer Risikofaktoren. Anasthesiol Intensivmed Notfallmed Schmerzther 45:488–493

    Article  PubMed  Google Scholar 

  87. Hildebrandt J, Pfingsten M, Franz C et al (1996) Das Göttinger Rücken Intensiv Programm (GRIP) – ein multimodales Behandlungsprogramm für Patienten mit chronischen Rückenschmerzen, Teil 1. Ergebnisse im Überblick. Schmerz 10:190–203

    Article  PubMed  CAS  Google Scholar 

  88. Pfingsten M, Hildebrandt J, Saur P (1997) Das Göttinger Rücken Intensiv Programm (GRIP) – ein multimodales Behandlungsprogramm für Patienten mit chronischen Rückenschmerzen, Teil 4. Prognostik und Fazit. Schmerz 11:30–41

    Article  PubMed  CAS  Google Scholar 

  89. Guzman J, Esmail R, Karjalainen K et al (2001) Multidisciplinary rehabilitation for chronic low back pain: systematic review. BMJ 322:1511–1516

    Article  PubMed  CAS  Google Scholar 

  90. Nagel B, Korb J (2009) Multimodale Schmerztherapie des Rückenschmerzes. Nachhaltig wirksam und kosteneffektiv. Orthopade 38:907–912

    Article  PubMed  CAS  Google Scholar 

  91. Kohles S, Barnes D, Gatchel RJ, Mayer TG (1989) Improved physical performance outcomes after functional restoration treatment in patients with chronic low-back pain. Spine 15(12):1321–1324

    Article  Google Scholar 

  92. Hildebrandt J, Pfingsten M, Saur P, Jansen J (1997) Prediction of success from a multidisciplinary treatment program for chronic low back pain. Spine 22(9):990–1001

    Article  PubMed  CAS  Google Scholar 

  93. Marnitz U, Weh L, Müller G et al (2008) Integrationsversorgung von Patienten mit Rückenschmerzen. Schmerzbezogene Ergebnisse und Arbeitsfähigkeit. Schmerz 22:415–423

    Article  PubMed  CAS  Google Scholar 

  94. http://www.multimodale-schmerztherapie.de. Zugegriffen: 25.02.2011

  95. Rogerson MD, Gatchel RJ, Bierner SM et al (2010) A cost utility analysis of interdisciplinary early intervention versus treatment as usual for high-risk acute low back pain patients. Pain Pract 10(5):382–395

    Article  PubMed  Google Scholar 

  96. Heymanns MW, Bururen S van, Knol DL et al (2010) The prognosis of chronic low back pain is determined by changes in pain and disability in the initial period. Spine J 10:847–856

    Article  Google Scholar 

  97. Linton SJ, Andersson MA (2000) A randomized trial of cognitive-behaviour intervention and two forms of information for patients with spinal pain. Spine 25(21):2825–2831

    Article  PubMed  CAS  Google Scholar 

  98. Gatchel RJ, Bernstein D, Stowell AW, Pransky G (2008) Psychosocial differences between high-risk acute vs. chronic low back pain patients. Pain Pract 8(2):91–97

    Article  PubMed  Google Scholar 

  99. DGSS (2009) Langzeitanwendung von Opioiden bei nicht tumorbedingten Schmerzen (LONTS). http://www.awmf.org/uploads/tx_szleitlinien/041–003 l.pdf

  100. Worz R, Bolten W, Heller B (1996) Flupirtin in comparison with chlormezanone in chronic musculoskeletal back pain. Result of a multicenter randomized double blind study. Fortschr Med 114:500–504

    PubMed  CAS  Google Scholar 

  101. Arzneimittelkommission der Deutschen Ärzteschaft (2007) Empfehlungen zur Therapie von Kreuzschmerzen, 3 Aufl. Arzneimittelkommission der Deutschen Ärzteschaft, Berlin

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Niemier, K. Multimodal, polypragmatisch und kostenintensiv. Manuelle Medizin 50, 16–27 (2012). https://doi.org/10.1007/s00337-011-0888-x

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