Abstract
In the Belgian Blue Cattle breed, coat color variation is mainly under the influence of a single autosomal locus, the roan locus, characterized by a pair of codominant alleles: r+ (black) and R (white). Heterozygous r + R animals have intermingled black and white hairs, yielding the “blue” phenotype typical of the breed. Major interest for the roan locus stems from its pleiotropic effect on fertility, owing to the critical role of the R allele in the determinism of White Heifer Disease. We describe the linkage mapping of the roan locus to bovine Chromosome (Chr) 5, in the interval between microsatellite markers BP1 and AGLA293, with an associated lodscore of 11.2. Moreover, we map a candidate gene, the Steel locus coding for the mast cell growth factor, to bovine Chr 5.
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Barendse, W., Armitage, S.M., Kossarek, L.M., Shalom, A., Kirkpatrick, B.W., Ryan, A.M., Clayton, D., Li, L., Neibergs, H.L., Zhang, N., Grosse, W.M., Weiss, J., Creighton, P., McCarthy, R., Ron, M., Teale, A.J., Fries, R., McGraw, R.A., Moore, S.S., Georges, M., Soller, M., Womack, J.E., Hetzel, D.J.S. (1994). A genetic linkage map of the bovine genome. Nature Genet. 6, 227–235.
Barrington, A., Pearson, K. (1906). On the inheritance of coat color in cattle. Biometrika 4, 427–464.
Bishop, M.D., Kappes, S.M., Keele, J.W., Stone, R.T., Senden, S.L.F., Hawkins, G.A., Solinas Toldo, S., Fries, R., Grosz, M.D., Yoo, J., Beattie. C.S. (1994). A genetic linkage map for cattle. R. (1990).
Brannan, C.I., Bedell, M.A., Resnick, J.L., Eppig, J.J., Handel, M.A., Williams, D.E., Lyman, S.D., Donovan, P.J., Jenkins, N.A., Copeland, N.G. (1992). Developmental abnormalities in Steel (17H) mice result from a splicing defect in the Steel factor cytoplasmic tail. Genes Dev. 6, 1832–1842.
Charlier, C., Coppieters, W., Farnir, F., Grobet, L., Leroy, P., Michaux, C., Mni, M., Schwers, A., Vanmanshoven, P., Hanset, R., Georges, M. (1995a). The mh gene causing double-muscling in cattle maps to bovine chromosome 2. Mamm. Genome, in press.
Charlier, C., Belanche, I., Brouwers, B., Coppieter, W., Karim, L., Vanmanshoven, P., Womack, J., Georges, M. (1995b). Mutations in the MSH receptor underly coat color polymorphism in cattle. In preparation.
Chevalet, C., Carpet, F. (1986). Statistical decision rules concerning synteny or independence between markers. Cytogenet. Cell Genet. 43, 132–139.
Dietz, A.B., Georges, M., Threadgill, D.W., Womack, J.E., Schuler, L.A. (1992). Somatic cell mapping, polymorphism, and linkage analysis of bovine prolactin-related proteins and placental lactogen. Genomics 14, 137–143.
Evvard, J.M., Shearer, P.S., Lindstrom, E.W., Smith, A.D.B. (1930). The inheritance of color and horns in blue gray cattle. Iowa Agríc. Exp. Stn. Res. Bull. 133, 1–16.
Georges, M., Nielsen, D., Mackinnon, M., Mishra, A., Okimoto, R., Pasquino, A.T., Sargeant, L.S., Sorensen, A., Steele, MR.R., Zhao, X., Womack, J.E., Hoeschele, I. (1995). Mapping quantitative trait loci controlling milk production by exploiting progeny testing. Genetics 139, 907–920.
Green, M.C. (1990). Catalog of mutant genes and polymorphic loci. In Genetic Variants and Strains of the Laboratory Mouse, M.F. Lyon, A.G. Searle, eds. (Oxford: Oxford University Press), pp. 333–335.
Hanset, R. (1959). L’hérédité des robes dans la race bleu-blanc de Moyenne et Haute Belgique. Ann. Méd. Vét. 3, 161–188.
Hanset, R. (1969a). Croisements expérimentaux avec des génisses atteintes de la White Heifer Disease. Ann. Méd. Vét. 113, 3–11.
Hanset, R. (1969b). La White Heifer Disease dans la race bovine de Moyenne et Haute Belgique: un bilan de dix années. Ann. Méd. Vét. 113, 12–21.
Hanset, R. (1985). Coat colour inheritance in the Belgian White and Blue cattle breed. Génét. Sél. Evol. 17, 443–458.
Hanset, R. Ansay, M. (1961). La White Heifer Disease: nouvelle description et essai de classification rationnelle de ses différentes formes. Ann. Méd. Vét. 105, 133–146.
Ibsen, H.L. (1933). Cattle inheritance. Genetics 18, 441–482.
Jackson, I.J. (1994). Molecular and developmental genetics of mouse coat color. Annu. Rev. Genet. 28, 189–217.
Kelly, E.M. (1974). Mouse News Lett. 50, 52.
Lathrop, M., Lalouel, J.M. (1984). Easy calculations of lodscores and genetic risk on small computers. Am. J. Hum. Genet. 36, 460–465.
Martin, F.H., Suggs, S.V., Langley, K.E., Lu, H.S., Ting, J., Okino, K.H., Morris, C.F., McNiece, I.K., Jacobsen, F.W., Mendiaz, E.A., Birkett, N.C., Smith, K.A., Johnson, M., Parker, V.P., Flores, J.C., Patel, A.C., Fisher, E.F., Erjavec, H.O., Herrera, C.J., Wypych, J., Sachdev, R.K., Pope, J.A., Leslie, I., Wen, D., Lin, C.H., Cupples, R.L., Zsebo, K.M. (1990). Primary structure and functional expression of rat and human stem cell factor DNAs. Cell 63, 203–211.
Taylor, B.A., Frankel, W.N., Burmeister, M., Bryda, E. (1993). Mouse Chromosome 10. Mamm. Genome 4(Suppl.), S154-S163.
Wriedt, C. (1925). Color-sided cattle. J. Hered. 16, 51–56.
Wright, S. (1971). Color inheritance in mammals: cattle. J. Hered. 8, 521–527.
Zhou, J.-H., Hikono, H., Ohtaki, M., Kubota, T., Sakurai, M. (1994). Cloning and characterization of cDNAs encoding two normal isoforms of bovine stem cell factor. Biochim. Biophys. Acta 1223, 148–150.
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Charlier, C., Denys, B., Belanche, J.I. et al. Microsatellite mapping of the bovine roan locus: A major determinant of White Heifer Disease. Mammalian Genome 7, 138–142 (1996). https://doi.org/10.1007/s003359900034
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DOI: https://doi.org/10.1007/s003359900034