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Clinical application of bilateral high temporal and spatial resolution dynamic contrast-enhanced magnetic resonance imaging of the breast at 7 T

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Abstract

Objective

The objective of our study was to evaluate the clinical application of bilateral high spatial and temporal resolution dynamic contrast-enhanced magnetic resonance imaging (HR DCE-MRI) of the breast at 7 T.

Methods

Following institutional review board approval 23 patients with a breast lesion (BIRADS 0, 4–5) were included in our prospective study. All patients underwent bilateral HR DCE-MRI of the breast at 7 T (spatial resolution of 0.7 mm3 voxel size, temporal resolution of 14 s). Two experienced readers (r1, r2) and one less experienced reader (r3) independently assessed lesions according to BI-RADS®. Image quality, lesion conspicuity and artefacts were graded from 1 to 5. Sensitivity, specificity and diagnostic accuracy were assessed using histopathology as the standard of reference.

Results

HR DCE-MRI at 7 T revealed 29 lesions in 23 patients (sensitivity 100 % (19/19); specificity of 90 % (9/10)) resulting in a diagnostic accuracy of 96.6 % (28/29) with an AUC of 0.95. Overall image quality was excellent in the majority of cases (27/29) and examinations were not hampered by artefacts. There was excellent inter-reader agreement for diagnosis and image quality parameters (κ = 0.89–1).

Conclusion

Bilateral HR DCE-MRI of the breast at 7 T is feasible with excellent image quality in clinical practice and allows accurate breast cancer diagnosis.

Key points

• Dynamic contrast-enhanced 7-T MRI is being developed in several centres.

• Bilateral high resolution DCE-MRI of the breast at 7 T is clinically applicable.

• 7-T HR DCE-MRI of the breast provides excellent image quality.

• 7-T HR DCE-MRI should detect breast cancer with high diagnostic accuracy.

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Acknowledgments

Funding was provided by the Austrian Nationalbank ‘Jubiläumsfond’ Project 5082.

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Authors and Affiliations

  1. Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    K. Pinker, P. Baltzer, M. Bernathova, M. Weber, D. Leithner & T. H. Helbich

  2. Department of Biomedical Imaging and Image-guided Therapy, MR Centre of Excellence, Medical University Vienna, Vienna, Austria

    W. Bogner, S. Trattnig, S. Gruber & O. Zaric

  3. Department of Radiology, King’s College, London, UK

    O. Abeyakoon

  4. Department of Surgery, Medical University Vienna, Vienna, Austria

    P. Dubsky

  5. Department of Pathology, Medical University Vienna, Vienna, Austria

    Z. Bago-Horvath

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  1. K. Pinker
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  2. W. Bogner
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  3. P. Baltzer
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  4. S. Trattnig
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  5. S. Gruber
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  8. O. Zaric
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  11. M. Weber
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  13. T. H. Helbich
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Correspondence to T. H. Helbich.

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Pinker, K., Bogner, W., Baltzer, P. et al. Clinical application of bilateral high temporal and spatial resolution dynamic contrast-enhanced magnetic resonance imaging of the breast at 7 T. Eur Radiol 24, 913–920 (2014). https://doi.org/10.1007/s00330-013-3075-8

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  • DOI: https://doi.org/10.1007/s00330-013-3075-8

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