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Can abdominal multi-detector CT diagnose spinal osteoporosis?

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Abstract

The aim of this study was to (1) generate quantitative CT (QCT) densitometric data based on routine abdominal multi-detector (MDCT) examinations and (2) investigate whether these data can be used to differentiate osteoporotic from healthy females. Twenty-five female patients (group A) with a history of radiotherapy were examined both with routine abdominal MDCT and standard QCT to generate a MDCT-to-QCT conversion equation. Twenty-one osteoporotic (group B) and 23 healthy female patients (group C) were also recruited in the study. Patients of groups B and C underwent routine abdominal MDCT examination for various clinical indications. Mean bone mineral density (BMD) in patients of group A was 103.4 mg/ml ± 32.8 with routine abdominal MDCT and 91.0 mg/ml ± 28.5 with QCT. Quantitative CT BMDQCT values for patients in groups B and C were calculated utilizing the BMDMDCT values derived from routine abdominal MDCT data sets and the MDCT to QCT conversion equation: \({\text{BMD}}_{{\text{QCT}}} = 0.78 \cdot {\text{BMD}}_{{\text{MDCT}}} + 10.13\). The calculated QCT densitometric data adequately differentiated osteoporotic from healthy females (area under ROC curve 0.828, p = 0.05). In conclusion, this study showed that in a group of female patients, QCT data derived from routine abdominal MDCT examinations discriminated osteoporotic from healthy subjects.

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Authors and Affiliations

  1. Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 2208, Iraklion, 71003, Crete, Greece

    Antonios E. Papadakis & John Damilakis

  2. Department of Radiology, Faculty of Medicine, University of Crete, P.O. Box 2208, Iraklion, 71003, Crete, Greece

    Apostolos H. Karantanas

  3. Department of Orthopedics, Faculty of Medicine, University Hospital of Heraklion, P.O. Box 2208, Iraklion, 71003, Crete, Greece

    Giorgos Papadokostakis

  4. Department of Radiotherapy, Faculty of Medicine, University Hospital of Heraklion, P.O. Box 2208, Iraklion, 71003, Crete, Greece

    Effie Petinellis

Authors
  1. Antonios E. Papadakis
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  2. Apostolos H. Karantanas
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  3. Giorgos Papadokostakis
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  4. Effie Petinellis
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  5. John Damilakis
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Correspondence to Antonios E. Papadakis.

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Papadakis, A.E., Karantanas, A.H., Papadokostakis, G. et al. Can abdominal multi-detector CT diagnose spinal osteoporosis?. Eur Radiol 19, 172–176 (2009). https://doi.org/10.1007/s00330-008-1099-2

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  • DOI: https://doi.org/10.1007/s00330-008-1099-2

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