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Interleukin-6 levels in synovial fluids of patients with rheumatoid arthritis correlated with the infiltration of inflammatory cells in synovial membrane

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Abstract

To compare the histological appearance of synovial membrane and interleukin (IL)-6 levels in synovial fluids of patients with rheumatoid arthritis (RA). Synovial tissue and synovial fluids were obtained from 51 knee joints with RA undergoing synovectomy or joint replacements. A histological inflammation score was determined based on the hyperplasia of the synovial lining and infiltration of inflammatory cells. The concentrations of IL-6 in synovial fluids were measured by ELISA. The association between IL-6 levels and histological findings was evaluated. We found a positive correlation between the infiltration of inflammation cells in synovial tissues and the concentration of IL-6 in synovial fluids. The IL-6 level in synovial fluid partially reflects histological synovial inflammation.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, School of Medicine, Nagasaki University, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan

    Tomoko Matsumoto, Toshiyuki Tsurumoto & Hiroyuki Shindo

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  1. Tomoko Matsumoto
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  2. Toshiyuki Tsurumoto
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  3. Hiroyuki Shindo
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Correspondence to Tomoko Matsumoto.

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Matsumoto, T., Tsurumoto, T. & Shindo, H. Interleukin-6 levels in synovial fluids of patients with rheumatoid arthritis correlated with the infiltration of inflammatory cells in synovial membrane. Rheumatol Int 26, 1096–1100 (2006). https://doi.org/10.1007/s00296-006-0143-2

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  • DOI: https://doi.org/10.1007/s00296-006-0143-2

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