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Autoimmune manifestations in viral hepatitis

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Abstract

Infections by the viruses responsible for hepatitis B, C and D are accompanied by a number of immunopathological manifestations. A link between infection and autoimmunity is particularly well documented for the hepatitis C virus. Immunopathological manifestations range from production of autoantibodies to overt autoimmune disease, including thyroiditis and autoimmune hepatitis, and to immune-complex-mediated disorders, including cryoglobulinaemia, glomerulonephritis and vasculitis. Several of these manifestations improve with successful antiviral treatment, directly incriminating the virus in their pathogenesis. Mechanisms considered responsible for hepatitis virus-related immunopathology, including molecular mimicry, impairment of regulatory T cells and activation of B lymphocytes, will be examined in this review.

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  1. Institute of Liver Studies and Paediatric Liver, GI & Nutrition Centre, King’s College Hospital, King’s College London School of Medicine, Denmark Hill, London, SE5 9RS, UK

    Diego Vergani & Giorgina Mieli-Vergani

  2. Institute of Liver Studies, King’s College Hospital, Denmark Hill, London, SE5 9RS, UK

    Diego Vergani

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Correspondence to Diego Vergani.

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This article is published as part of the Special Issue on Immunopathology of viral hepatitis

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Vergani, D., Mieli-Vergani, G. Autoimmune manifestations in viral hepatitis. Semin Immunopathol 35, 73–85 (2013). https://doi.org/10.1007/s00281-012-0328-6

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