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Glycosylation of IgA1 and pathogenesis of IgA nephropathy

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Abstract

IgA nephropathy, described in 1968 as IgA-IgG immune-complex disease, is an autoimmune disease. Galactose-deficient IgA1 is recognized by unique autoantibodies, resulting in the formation of pathogenic immune complexes that ultimately induce glomerular injury. Thus, formation of the galactose-deficient IgA1-containing immune complexes is a critical factor in the pathogenesis of IgA nephropathy. Studies of molecular defects of IgA1 can define new biomarkers specific for IgA nephropathy that can be developed into clinical assays to aid in the diagnosis, assessment of prognosis, and monitoring of disease progression.

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Acknowledgments

This work is dedicated to Milan Tomana, a pioneer in the studies of immunoglobulin glycosylation, at the occasion of his 80th birthday. This study is supported in part by grants DK078244, DK082753, DK083663, DK075868, DK080301, DK077279, DK071802, and GM098539 from the National Institutes of Health and a grant from the IgA Nephropathy Foundation of America.

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  1. University of Alabama at Birmingham, Birmingham, AL, USA

    Jan Novak, Bruce A. Julian, Jiri Mestecky & Matthew B. Renfrow

  2. Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, BBRB 761A (Box 1), Birmingham, AL, 35294, USA

    Jan Novak

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This article is published as part of the Special Issue on Glycosylation and Immunity [34:3].

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Novak, J., Julian, B.A., Mestecky, J. et al. Glycosylation of IgA1 and pathogenesis of IgA nephropathy. Semin Immunopathol 34, 365–382 (2012). https://doi.org/10.1007/s00281-012-0306-z

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