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Assessing the therapeutic and toxicological effects of cesium chloride following administration to nude mice bearing PC-3 or LNCaP prostate cancer xenografts

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Abstract

Purpose

The purpose of this study was to assess the therapeutic and toxicological effects of cesium chloride (CsCl) administration in mice bearing prostate cancer tumors.

Methods

Three CsCl dose titration studies were completed in tumor-bearing and non-tumor-bearing athymic nude mice. All mice were administered either vehicle (controls), 150, 300, 600, 800, 1,000, or 1,200 mg/kg of CsCl once daily by oral gavage for 30 consecutive days. Body mass was measured daily, food and water consumption were measured every 2 days, and tumor volume was measured twice weekly. Histopathological analysis was conducted on tissues collected from each of the studies. Serum AST/ALT and creatinine were also measured.

Results

Administration of 800–1,200 mg/kg CsCl reduced PC-3 tumor growth but had no effect on LNCaP tumors. Administration of 800–1,200 mg/kg CsCl also resulted in increased water consumption, bladder crystal development, and higher prevalence of cardiac fibrin clots. An observed loss in body mass was dependent on the xenograft type and concentration of CsCl administered. CsCl did not affect serum AST/ALT and creatinine levels.

Conclusions

CsCl may have a therapeutic effect against prostate cancer, but one cannot overlook the acute toxicities also described.

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Acknowledgments

We would like to thank Catherine Wood and Mary Bowden for their assistance in the animal experiments. We would also like to thank CIHR for funding this project (CIHR operating grant MOP-62792).

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Authors and Affiliations

  1. Urologic Sciences, The Prostate Center at Vancouver General Hospital, 2660 Oak Street, Vancouver, BC, Canada, V6H 3Z4

    Jonathan C. Low, Ladan Fazli, Andy Eberding, Hans Adomat & Emma S. Guns

  2. Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada, V6T 1Z3

    Jonathan C. Low & Kishor M. Wasan

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  1. Jonathan C. Low
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  2. Kishor M. Wasan
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  6. Emma S. Guns
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Correspondence to Emma S. Guns.

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Low, J.C., Wasan, K.M., Fazli, L. et al. Assessing the therapeutic and toxicological effects of cesium chloride following administration to nude mice bearing PC-3 or LNCaP prostate cancer xenografts. Cancer Chemother Pharmacol 60, 821–829 (2007). https://doi.org/10.1007/s00280-007-0429-4

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