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Experiences in US-Guided Percutaneous Radiofrequency Ablation of 44 Renal Tumors in 31 Patients: Analysis of Predictors for Complications and Technical Success

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Abstract

Purpose

Preliminary clinical studies have shown the feasibility, safety, and efficacy of radiofrequency thermal ablation (RFA) of renal tumors, but only a few have analyzed the prognostic factors for technical success and there are no long-term results. Our objective was to statistically evaluate our mid-term results of percutaneous US-guided RFA in order to define predictors for complications and technical success.

Methods

We selected for treatment 44 tumors in 31 patients (24 with renal cell carcinoma, 7 with hereditary tumors, 15 with a solitary kidney), up to 5 cm in diameter.

Results

Eight adverse events occurred; 3 (6.8%) were major complications, successfully treated with interventional radiology procedures in 2 cases. Exophytic extension of the tumor was protective against complications (p = 0.040). Technical success was obtained in 38 lesions after one RFA session and in 39 (89%) after one more session, when possible. At the end of treatment, central extension was the only negative predictor for technical success (p = 0.007), while neither size >3 cm (p = 0.091) nor other prognostic factors were statistically significant.

Conclusion

US-guided percutaneous RFA can be proposed for non-central renal tumors up to 5 cm, also in patients without surgical contraindications, thanks to a low incidence of complications and a high success rate. Randomized controlled trials versus surgery are now needed to investigate long-term comparative results.

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Acknowledgment

The work of E.P. was supported by the Compagnia di San Paolo, Special Project Oncology. Presented at CIRSE 2004.

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Authors and Affiliations

  1. Institute of Diagnostic and Interventional Radiology, University of Turin, Via Genova 3, Turin, 10126, Italy

    Andrea Veltri, Amedeo Calvo, Irene Tosetti, Andrea Genovesio, Valentina Virzì & Giovanni Gandini

  2. Unit of Cancer Epidemiology, University of Turin, Via Santena 7, Turin, 10126, Italy

    Eva Pagano

  3. Unit of Urology, San Giovanni Battista Hospital, C.so Bramante 88, Turin, 10126, Italy

    Ugo Ferrando

  4. Institute of Urology, University of Turin, C.so Bramante 88, Turin, 10126, Italy

    Dario Fontana

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  1. Andrea Veltri
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  2. Amedeo Calvo
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  3. Irene Tosetti
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  4. Eva Pagano
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  5. Andrea Genovesio
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  7. Ugo Ferrando
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  8. Dario Fontana
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  9. Giovanni Gandini
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Correspondence to Andrea Veltri.

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Veltri, A., Calvo, A., Tosetti, I. et al. Experiences in US-Guided Percutaneous Radiofrequency Ablation of 44 Renal Tumors in 31 Patients: Analysis of Predictors for Complications and Technical Success. Cardiovasc Intervent Radiol 29, 811–818 (2006). https://doi.org/10.1007/s00270-005-0261-3

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  • DOI: https://doi.org/10.1007/s00270-005-0261-3

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