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Venous Thromboembolism After Surgery for Benign Prostatic Hyperplasia

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Abstract

A systematic review has been performed on venous thromboembolism after surgery for benign prostatic hyperplasia. The risk of deep vein thrombosis is two to four times higher after open surgery than after transurethral resection. The risk after the newer transurethral methods (laser, radiofrequency, heat) is not known. Specific studies on thromboprophylaxis are few and have limited numbers of patients. Nonetheless, thromboprophylaxis (heparin) reduces the frequency of postoperative deep vein thrombosis after open surgery. Studies on patients undergoing transurethral resection are lacking. Antifibrinolytic treatment to diminish bleeding does not seem to increase the risk of thrombosis.

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References

  1. Bergqvist D, Blomqvist P, Eliasson M et al (2002) Blodpropp-förebyggande, diagnostik och behandling av venös tromboembolism: en systematisk kunskapssammanställning. In: SBU-Rapport No. 158. pp I:1–546, II:541–350, III:541–580

  2. Geerts WH, Bergqvist D, Pineo GF et al (2008) Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 133:381S–453S

    Article  PubMed  CAS  Google Scholar 

  3. Hjertberg H, Olsson J, Ekstrom T et al (1996) Do low molecular weight heparin and dextran increase the blood loss in transurethral resection of the prostate? Br J Urol 78:897–900

    PubMed  CAS  Google Scholar 

  4. Becker J, Schampi B (1973) The incidence of postoperative venous thrombosis of the legs: a comparative study on the prophylactic effect of dextran 70 and electrical calf-muscle stimulation. Acta Chir Scand 139:357–367

    PubMed  CAS  Google Scholar 

  5. Gordon-Smith I, Hickman J, El Masri S (1972) The effect of the fibrinolytic inhibitor epsilon-aminocaproic acid on the incidence of deep-vein thrombosis after prostatectomy. Br J Surg 59:522–524

    Article  PubMed  CAS  Google Scholar 

  6. Hedlund PO (1975) Postoperative venous thrombosis in benign prostatic disease: a study of 316 patients, using the 125I-fibrinogen uptake test. Scand J Urol Nephrol 27:1–100

    PubMed  Google Scholar 

  7. Sinclair J, Forbes CD, Prentice CR et al (1976) The incidence of deep vein thrombosis in prostatectomised patients following the administration of the fibrinolytic inhibitor, aminocaproic acid (EACA). Urol Res 4:129–131

    Article  PubMed  CAS  Google Scholar 

  8. Clagett GP, Reisch JS (1988) Prevention of venous thromboembolism in general surgical patients: results of meta-analysis. Ann Surg 208:227–240

    Article  PubMed  CAS  Google Scholar 

  9. Collins R, Scrimgeour A, Yusuf S et al (1988) Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin: overview of results of randomized trials in general, orthopedic, and urologic surgery. N Engl J Med 318:1162–1173

    Article  PubMed  CAS  Google Scholar 

  10. Gruber U (1975) Dextran and the prevention of postoperative thromboembolic complications. Surg Clin North Am 55:679–694

    PubMed  CAS  Google Scholar 

  11. Jorgensen LN, Wille-Jorgensen P, Hauch O (1993) Prophylaxis of postoperative thromboembolism with low molecular weight heparins. Br J Surg 80:689–704

    Article  PubMed  CAS  Google Scholar 

  12. Kakkar VV (1977) Fibrinogen uptake test for detection of deep vein thrombosis: a review of current practice. Semin Nucl Med 7:229–244

    Article  PubMed  CAS  Google Scholar 

  13. Koch A, Bouges S, Ziegler S et al (1997) Low molecular weight heparin and unfractionated heparin in thrombosis prophylaxis after major surgical intervention: update of previous meta- analyses. Br J Surg 84:750–759

    Article  PubMed  CAS  Google Scholar 

  14. Leizorovicz A, Haugh MC, Chapuis FR et al (1992) Low molecular weight heparin in prevention of perioperative thrombosis. BMJ 305:913–920

    Article  PubMed  CAS  Google Scholar 

  15. Mismetti P, Laporte S, Darmon JY et al (2001) Meta-analysis of low molecular weight heparin in the prevention of venous thromboembolism in general surgery. Br J Surg 88:913–930

    Article  PubMed  CAS  Google Scholar 

  16. Nurmohamed MT, Rosendaal FR, Buller HR et al (1992) Low-molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis. Lancet 340:152–156

    Article  PubMed  CAS  Google Scholar 

  17. Nicolaides A, Fareed J, Kakkar AK et al (2006) Prevention and treatment of venous thromboembolism. Int Angiol 25:101–161

    Google Scholar 

  18. National Institute for Health and Clinical Excellence (NICE) (2007) Venous thromboembolism: reducing the risk of venous thromboembolism in inpatients undergoing surgery. http://www.nice.org.uk/CG46

  19. Anonymous (2004) Socialstyrelsens riktlinjer för vård av blodpropp. pp 102–103

  20. Donat R, Mancey-Jones B (2002) Incidence of thromboembolism after transurethral resection of the prostate (TURP): a study on TED stocking prophylaxis and literature review. Scand J Urol Nephrol 36:119–123

    Article  PubMed  CAS  Google Scholar 

  21. Becker J, Borgström S (1968) Incidence of thrombosis associated with epsilon-aminocaproic acid administration and with combined epsilon-aminocaproic acid and subcutaneous heparin therapy. Acta Chir Scand 134:343

    PubMed  CAS  Google Scholar 

  22. Becker J, Borgstrom S, Saltzman GF (1970) Incidence of thrombosis associated with epsilon-aminocaproic acid administration and with combined epsilon-aminocaproic acid and subcutaneous heparin therapy. II. A clinical study with the aid of intravenous phlebography. Acta Chir Scand 136:167–171

    PubMed  CAS  Google Scholar 

  23. Browse N, Jackson B, Mayo ME et al (1974) The value of mechanical method of preventing postoperative calf vein thrombosis. Br J Surg 61:219–223

    Article  PubMed  CAS  Google Scholar 

  24. Crawford ED, Dumbadze I, Ratledge HW et al (1978) Deep venous thrombosis following transurethral resection of the prostate: diagnosis by phleborheography. J Urol 120:438–441

    PubMed  CAS  Google Scholar 

  25. Mayo ME, Halil T, Browse NL (1971) The incidence of deep vein thrombosis after prostatectomy. Br J Urol 43:738–742

    Article  PubMed  CAS  Google Scholar 

  26. Nicolaides AN, Dupont PA, Desai S et al (1972) Small doses of subcutaneous sodium heparin in preventing deep venous thrombosis after major surgery. Lancet 2:890–893

    Article  PubMed  CAS  Google Scholar 

  27. Nicolaides AN, Field ES, Kakkar VV et al (1972) Prostatectomy and deep-vein thrombosis. Br J Surg 59:487–488

    Article  PubMed  CAS  Google Scholar 

  28. Rosenberg I, Evans M, Polock A (1974) Prophylaxis of postoperative leg vein thrombosis by low dose subcutaneous heparin or perioperative calf muscle stimulation: a controlled clinical trial. BMJ 1:649–651

    Article  Google Scholar 

  29. Schaub N, Duckert F, Fridrich R et al (1975) [Incidence of postoperative deep vein thrombosis in general surgical and urological patients: an investigation by means of the 125I-fibrinogen test in 95 patients without prophylaxis (author’s translation).] Langenbecks Arch Chir 340:23–34

    Google Scholar 

  30. Von Hospenthal J, Frey C, Rutishauser G et al (1977) [Prevention of thromboembolic complications in transurethral resection of the prostate (author’s translation)]. Urologe A 16:88–92

    Google Scholar 

  31. Bergqvist D (1983) Postoperative thromboembolism: frequency, etiology, prophylaxis. Springer, Berlin

    Google Scholar 

  32. Van Arsdalen KN, Barnes RW, Clarke G et al (1983) Deep vein thrombosis and prostatectomy. Urology 21:461–463

    Article  PubMed  Google Scholar 

  33. Hassan MA, El Shiekh A, Rahman EA et al (1974) Proceedings: prostatectomy and deep vein thrombosis in Sudanese patients. West Afr J Pharmacol Drug Res 2:110P

    CAS  Google Scholar 

  34. Hassan MA, Rahman EA, Rahman IA (1974) Prostatectomy and deep vein thrombosis in Sudanese patients. Br J Surg 61:650–652

    Article  PubMed  CAS  Google Scholar 

  35. Hendolin H, Mattila MA, Poikolainen E (1981) The effect of lumbar epidural analgesia on the development of deep vein thrombosis of the legs after open prostatectomy. Acta Chir Scand 147:425–429

    PubMed  CAS  Google Scholar 

  36. Presman D, Cruz R (1960) The prevention of postoperative thrombophlebitis following prostatic surgery. J Urol 84:158–161

    PubMed  CAS  Google Scholar 

  37. Bejjani BB, Chen DC, Nolan NG et al (1983) Minidose heparin in transurethral prostatectomy. Urology 22:251–254

    Article  PubMed  CAS  Google Scholar 

  38. Hedlund PO, Blomback M (1981) The effects of low-dose heparin treatment on patients undergoing transvesical prostatectomy. Urol Res 9:147–152

    Article  PubMed  CAS  Google Scholar 

  39. Vandendris M, Kutnowski M, Futeral B et al (1980) Prevention of postoperative deep-vein thrombosis by low-dose heparin in open prostatectomy. Urol Res 8:219–221

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Surgical Sciences, Section of Vascular Surgery, University Hospital, 751 85, Uppsala, Sweden

    David Bergqvist

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  1. David Bergqvist
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Correspondence to David Bergqvist.

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Bergqvist, D. Venous Thromboembolism After Surgery for Benign Prostatic Hyperplasia. World J Surg 35, 1824–1828 (2011). https://doi.org/10.1007/s00268-011-1150-3

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