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Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty

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Abstract

Purpose

Our aim was to evaluate the effectiveness of two different dosing regimens of human recombinant erythropoietin (rHu-EPO) for preoperative autologous blood collection in patients undergoing total hip arthroplasty (THA).

Methods

Prospective randomised trials in which erythropoietin 15,000 IU was administered intravenously twice a week or 30,000 IU once a week (total 90,000 IU) combined with ferrous II sulphate (Ferro-Gradumet 2) orally and compared with Ferro-Gradumet 2 alone.

Results

Although different dosing regimens of rHu-EPO administration during preoperative autologous blood donation have similar effects on the collection of two units of autologous blood, preoperative haemoglobin level and perioperative allogenic blood transfusion, a once weekly dose regimen of rHu-EPO was more convenient (although not statistically significantly) for patients.

Conclusion

We recommend the more practical and comfortable but yet highly effective therapeutic regimen with a single weekly intravenous administration of rHu-EPO for patients scheduled for THA.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Clinical Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia

    Melita Buljan, Goran Bicanic, Branko Tripkovic & Domagoj Delimar

  2. Department of Internal Medicine, Division of Hematology, University Hospital Centre Zagreb, Zagreb, Croatia

    Damir Nemet

  3. Department of Clinical Transfusiology, University Hospital Centre Zagreb, Zagreb, Croatia

    Branka Golubic-Cepulic

Authors
  1. Melita Buljan
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  2. Damir Nemet
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  3. Branka Golubic-Cepulic
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  4. Goran Bicanic
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  5. Branko Tripkovic
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  6. Domagoj Delimar
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Corresponding author

Correspondence to Goran Bicanic.

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Buljan, M., Nemet, D., Golubic-Cepulic, B. et al. Two different dosing regimens of human recombinant erythropoietin beta during preoperative autologous blood donation in patients having hip arthroplasty. International Orthopaedics (SICOT) 36, 703–709 (2012). https://doi.org/10.1007/s00264-011-1367-7

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