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Diffuse pigmented villonodular synovitis of the foot and ankle treated with surgery and radiotherapy

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Abstract

We followed up seven patients with histologically confirmed diffuse pigmented villonodular synovitis in a prospective study between 1992 and 2001. The mean age at diagnosis was 30.7 years. The patients underwent synovectomy, followed by radiotherapy with a total dose of 35 Gy in 20 fractions. In all cases, the excision was considered incomplete when examined histologically. At an average follow up of 24 (18–36) months, six patients reported better function and reduced levels of pain. One patient remained symptomatic but did not have a recurrence. We conclude that a combined approach to a primary pigmented villonodular synovitis of the foot and ankle may reduce the risk of recurrence without functional impairment.

Résumé

Nous avons suivi sept malades avec une synovite villonodulaire pigmentée diffuse confirmé histologiquement dans une étude prospective entre 1992 et 2001. L'âge moyen au diagnostic était de 30,7 ans. Les malades ont subi une synovectomie suivie d'une radiothérapie avec une dose totale de 35 Gy en 20 fractions. Dans tous les cas, la résection a été considérée incomplète à l'examen histologique. À une moyenne de suivi de 24 (18–36) mois, six malades ont une meilleure fonction et un niveau réduit de douleur. Un malade est resté symptomatique, mais sans récidive. Nous concluons qu'un traitement combiné d'une synovite villonodulaire pigmenté du pied et de la cheville peut réduire le risque de récidive sans dégradation fonctionnelle.

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References

  1. Blanco CE, Leon HO, Guthrie TB (2001) Combined partial arthroscopic synovectomy and radiation therapy for diffuse pigmented villonodular synovitis of the knee. Arthroscopy 17:527–531

    Article  PubMed  CAS  Google Scholar 

  2. Brenner DJ, Curtis RE, Hall EJ, Ron E (2000) Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery. Cancer 88(2):398–406

    Article  PubMed  CAS  Google Scholar 

  3. Broerse JJ, Snijders-Keilholz A, Jansen JT, Zoetelief J, Klein C, Seegenschmiedt MH (1999) Assessment of a carcinogenic risk for treatment of Graves' ophthalmopathy in dependence on age and irradiation geometry. Radiother Oncol 53(3):205–208

    Article  PubMed  CAS  Google Scholar 

  4. Granowitz SP, Mankin HJ (1967) Localized pigmented villonodular synovitis of the knee: report of five cases. J Bone Joint Surg Am 49:122–128

    PubMed  CAS  Google Scholar 

  5. Hildebrandt G, Seed MP, Freemantle CN, Alam CA, Colville-Nash PR, Trott KR (1998) Mechanisms of the anti-inflammatory activity of low-dose radiation therapy. Int J Radiat Biol 74(3):367–78

    Article  PubMed  CAS  Google Scholar 

  6. Kottal RA, Vogler JB, Matamoros A, Alexander AH, Cookson JL (1987) Pigmented villonodular synovitis: a report of MR imaging in two cases. Radiology 163:551–553

    PubMed  CAS  Google Scholar 

  7. Metayer C, Lynch CF, Clarke EA, Glimelius B, Storm H, Pukkala E, Joensuu T, van Leeuwen FE, van't Veer MB, Curtis RE, Holowaty EJ, Andersson M, Wiklund T, Gospodarowicz M, Travis LB (2000) Second cancers among long-term survivors of Hodgkin's disease diagnosed in childhood and adolescence. J Clin Oncol 18(12):2435–2443

    PubMed  CAS  Google Scholar 

  8. Munker R, Grutzner S, Hiller E, Aydemir U, Enne W, Dietzfelbinger H, Busch M, Haas R, Emmerich B, Schmidt M, Duhmke E, Holzel D, Wilmanns W (1999) Second malignancies after Hodgkin's disease: the Munich experience. Ann Hematol 78(12):544–554

    Article  PubMed  CAS  Google Scholar 

  9. O'Sullivan B, Cummings B, Catton C et al (1995) Outcome following radiation treatment for high-risk pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys 32:777–786

    Article  PubMed  Google Scholar 

  10. Ruther U, Dieckmann K, Bussar-Maatz R, Eisenberger F (2000) Second malignancies following pure seminoma. Oncology 58(1):75–82

    Article  PubMed  CAS  Google Scholar 

  11. Trott KR (1994) Therapeutic effects of low radiation doses. Strahlenther Onkol 170(1):1–12

    PubMed  CAS  Google Scholar 

  12. Trott KR, Kamprad F (1999) Radiobiological mechanisms of anti-inflammatory radiotherapy. Radiother Oncol 51(3):197–203

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Bone and Soft Tissue Tumour Unit, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, London, HA7 4LP, UK

    M. Lee, S. Mahroof, J. Pringle, T. W. R. Briggs & S. R. Cannon

  2. The Marie Curie Research Wing for Oncology, Mount Vernon Hospital, London, UK

    S. C. Short

  3. 3 Tankerfield Place, Romeland Hill, St. Albans, Herts, AL3 4HH, UK

    M. Lee

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  1. M. Lee
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  2. S. Mahroof
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  3. J. Pringle
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  4. S. C. Short
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  5. T. W. R. Briggs
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  6. S. R. Cannon
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Correspondence to M. Lee.

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Lee, M., Mahroof, S., Pringle, J. et al. Diffuse pigmented villonodular synovitis of the foot and ankle treated with surgery and radiotherapy. International Orthopaedics (SICO 29, 403–405 (2005). https://doi.org/10.1007/s00264-005-0004-8

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  • DOI: https://doi.org/10.1007/s00264-005-0004-8

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