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Current approaches in dendritic cell generation and future implications for cancer immunotherapy

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Abstract

The discovery of tumor-associated antigens, which are either selectively or preferentially expressed by tumors, together with an improved insight in dendritic cell biology illustrating their key function in the immune system, have provided a rationale to initiate dendritic cell-based cancer immunotherapy trials. Nevertheless, dendritic cell vaccination is in an early stage, as methods for preparing tumor antigen presenting dendritic cells and improving their immunostimulatory function are continuously being optimized. In addition, recent improvements in immunomonitoring have emphasized the need for careful design of this part of the trials. Still, valuable proofs-of-principle have been obtained, which favor the use of dendritic cells in subsequent, more standardized clinical trials. Here, we review the recent developments in clinical DC generation, antigen loading methods and immunomonitoring approaches for DC-based trials.

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Acknowledgment

This work was supported by the Belgian Program on Interuniversity Poles of Attraction, by a grant of the Belgian Foundation against Cancer, by an Integrated Project and Network of Excellence sponsored by the EU and by a grant of the Fund for Scientific Research (FWO-V). ST was supported by a grant from the ‘Vlaamse Liga tegen Kanker’. JLA, KB and AB are post-doctoral fellows of the Fund for Scientific Research Flanders, Belgium (FWO Vlaanderen).

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  1. Laboratory of Molecular and Cellular Therapy, Department of Physiology and Immunology, Medical School of the Vrije Universiteit Brussel, Laarbeeklaan 103/E, 1090, Brussels, Belgium

    Sandra Tuyaerts, Joeri L. Aerts, Jurgen Corthals, Carlo Heirman, Karine Breckpot, Kris Thielemans & Aude Bonehill

  2. Medical Oncology, Oncology Center, University Hospital Brussels, Free University Brussels, Laarbeeklaan 101, 1090, Brussels, Belgium

    Bart Neyns

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  1. Sandra Tuyaerts
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Correspondence to Aude Bonehill.

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Tuyaerts, S., Aerts, J.L., Corthals, J. et al. Current approaches in dendritic cell generation and future implications for cancer immunotherapy. Cancer Immunol Immunother 56, 1513–1537 (2007). https://doi.org/10.1007/s00262-007-0334-z

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