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Vaccination therapy in prostate cancer

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Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Abstract

Radical prostatectomy and radiation therapy provide excellent localized prostate cancer (PC) control. Although the majority of prostate carcinoma is nowadays diagnosed at early stages with favourable risk features, in patients up to 30–40% it recurs within 10 years. Furthermore, the lack of effective therapies, once prostate carcinoma becomes refractory to androgen deprivation, mandates the development of alternative therapeutic options. There is a growing interest in harnessing the potency and specificity of anti-tumour immunity through the generation of fully competent dendritic cells and tumour reactive effector lymphocytes. Several strategies to treat or prevent the development of metastatic PC have been explored in clinical trials and are summarized in this review, considering also the feasibility and safety of these approaches. In some cases clinical responses were achieved showing that vaccine-primed T cells induced anti-tumour activity in vivo. The present findings and perspectives of the immunologic interventions in PC patients will be discussed.

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Abbreviations

ADT:

Androgen deprivation therapy

APC:

Antigen-presenting cells

DCs:

Dendritic cells

PAP:

Prostatic acid phosphatase

PC:

Prostate cancer

PSA:

Prostate-specific antigen

PSMA:

Prostate-specific membrane antigen

RT:

Radiotherapy

TAA:

Tumour-associated antigens

TGFβ:

Transforming growth factor β

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Authors and Affiliations

  1. Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133, Milan, Italy

    Andrea Marrari, Manuela Iero, Lorenzo Pilla, Giorgio Parmiani & Licia Rivoltini

  2. Unit of Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Sergio Villa

  3. Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Roberto Salvioni

  4. Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Riccardo Valdagni

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  1. Andrea Marrari
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  2. Manuela Iero
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Correspondence to Andrea Marrari.

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Marrari, A., Iero, M., Pilla, L. et al. Vaccination therapy in prostate cancer. Cancer Immunol Immunother 56, 429–445 (2007). https://doi.org/10.1007/s00262-006-0233-8

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