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A listing of human tumor antigens recognized by T cells: March 2004 update

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Abstract

The technological advances occurred in the last few years have led to a great increase in the number of tumor associated antigens (TAA) that are currently available for clinical applications. In this review we provide a comprehensive list of human tumor antigens as reported in the literature updated at Feburary 2004. The list includes all T cell-defined epitopes, while excluding analogs or artificially modified epitopes, as well as virus-encoded and antibodies-recognized antigens. TAAs are listed in alphabetical order along with the epitope sequence and the HLA allele which restricts recognition by T cells. Data on the tissue distribution of each antigen are also provided together with an extensive bibliography that allows a rapid search for any additional information may be needed on each single antigen or epitope. Overall, the updated list is a database tool for clinicians, scientists and students who have an interest in the field of tumor immunology and immunotherapy.

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Abbreviations

AFP:

Alpha (α)-fetoprotein

AIM-2:

Interferon-inducible protein absent in melanoma 2

ALL:

Acute lymphoblastic leukemia

AML:

Acute myeloid leukemia

707-AP:

707 alanine proline

APL:

Acute promyelocytic leukemia

ART-4:

Adenocarcinoma antigen recognized by T cells 4

BAGE:

B antigen

bcr-abl:

Breakpoint cluster region-Abelson

CAMEL:

CTL-recognized antigen on melanoma

CAP-1:

Carcinoembryonic antigen peptide-1

CASP-8:

Caspase 8

CDC27:

Cell division cycle 27

CDK4:

Cyclin-dependent kinase 4

CEA:

Carcinoembryonic antigen

CLCA2:

Calcium-activated chloride channel 2

CML:

Chronic myelogenous leukemia

CT:

Cancer-testis (antigen)

CTL:

Cytotoxic T lymphocytes

Cyp-B:

Cyclophilin B

DAM:

Differentiation antigen melanoma (the epitopes of DAM-6 and DAM-10 are equivalent, but the gene sequences are different. DAM-6 is also called MAGE-B2 and DAM-10 is also called MAGE-B1)

ELF2:

Elongation factor 2

Ep-CAM:

Epithelial cell adhesion molecule

EphA2, 3:

Ephrin type-A receptor 2, 3

Ets:

E-26 transforming specific (family of transcription factors)

ETV6-AML1:

Ets variant gene 6 / acute myeloid leukemia 1 gene ETS

FGF-5:

Fibroblast growth factor 5

FN:

Fibronectin

G250:

Glycoprotein 250

GAGE:

G antigen

GnT-V:

N-Acetylglucosaminyltransferase V

Gp100:

Glycoprotein 100 kDa

HAGE:

Helicase antigen

HER-2/neu:

Human epidermal receptor 2/neurological

HLA-A*0201-R170I:

Arginine (R) to isoleucine (I) exchange at residue 170 of the α-helix of the α2-domain in the HLA-A2 gene

H/N:

Head and neck

HSP70-2 M:

Heat shock protein 70-2 mutated

HST-2:

Human signet-ring tumor 2

hTERT:

Human telomerase reverse transcriptase

iCE:

Intestinal carboxyl esterase

IL-13Rα2:

Interleukin 13 receptor α2 chain

KIAA0205:

Name of the gene as it appears in databases

LAGE:

L antigen

LDLR/FUT:

Low density lipid receptor / GDP-L-fucose:β-D-galactosidase 2-α-L-fucosyltransferase

MAGE:

Melanoma antigen

MART-1/Melan-A:

Melanoma antigen recognized by T cells-1 / melanoma antigen A

MART-2:

Melanoma Ag recognized by T cells-2

MC1R:

Melanocortin 1 receptor

M-CSF:

Macrophage colony-stimulating factor gene

MHC:

Major histocompatibility complex

MSI:

Microsatellite instability

MUC1, 2:

Mucin 1, 2

MUM-1, -2, -3:

Melanoma ubiquitous mutated 1, 2, 3

NA88-A:

NA cDNA clone of patient M88

Neo-PAP:

Neo-poly(A) polymerase

NPM/ALK:

Nucleophosmin/anaplastic lymphoma kinase fusion protein

NSCLC:

Non–small cell lung carcinoma

NY-ESO-1:

New York esophageous 1

OA1:

Ocular albinism type 1 protein

OGT:

O-Linked N-acetylglucosamine transferase gene

ORF:

Open reading frame

OS-9:

Name of the gene as it appears in databases

P15:

Protein 15

p190 minor bcr-abl:

Protein of 190-kDa bcr-abl

Pml/RARα:

Promyelocytic leukemia / retinoic acid receptor α

PRAME:

Preferentially expressed antigen of melanoma

PSA:

Prostate-specific antigen

PSMA:

Prostate-specific membrane antigen

PTPRK:

Receptor-type protein-tyrosine phosphatase kappa

RAGE:

Renal antigen

RCC:

Renal cell carcinoma

RU1, 2:

Renal ubiquitous 1, 2

SAGE:

Sarcoma antigen

SART-1, -2, -3:

Squamous antigen rejecting tumor 1, 2, 3

SCC:

Squamous cell carcinoma

SSX-2:

Synovial sarcoma, X breakpoint 2

Survivin-2B:

Intron 2-retaining survivin

SYT/SSX:

Synaptotagmin I / synovial sarcoma, X fusion protein

TAA:

Tumor-associated antigen

TEL/AML1:

Translocation Ets-family leukemia/acute myeloid leukemia 1

TGFβRII:

Transforming growth factor β receptor 2

TPI:

Triosephosphate isomerase

TRAG-3:

Taxol resistant associated protein 3

TRG:

Testin-related gene

TRP-1:

Tyrosinase-related protein 1, or gp75

TRP-2:

Tyrosinase-related protein 2

TRP-2/INT2:

TRP-2/intron 2

TRP-2/6b:

TRP-2/novel exon 6b

TSTA:

Tumor-specific transplantation antigens

WT1:

Wilms’ tumor gene

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Acknowledgements

The authors would like to thank Ms Grazia Barp for editorial assistance. This work was supported in part by a grant of the European Community (QLK3-1999-00064) and the Italian Ministry of Education, University and Research (Rome, FIRB RBNE017B4C).

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  1. Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Via G. Venezian 1, 20133, Milan, Italy

    Luisa Novellino, Chiara Castelli & Giorgio Parmiani

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  1. Luisa Novellino
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  2. Chiara Castelli
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Correspondence to Chiara Castelli.

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Novellino, L., Castelli, C. & Parmiani, G. A listing of human tumor antigens recognized by T cells: March 2004 update. Cancer Immunol Immunother 54, 187–207 (2005). https://doi.org/10.1007/s00262-004-0560-6

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