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Injecting epidural and intra-articular triamcinolone in HIV-positive patients on ritonavir: beware of iatrogenic Cushing’s syndrome

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Abstract

We report two HIV-positive patients on highly active antiretroviral therapy (HAART) who developed clinical features in keeping with secondary adrenal suppression following epidural and subacromial triamcinolone. Both patients were on ritonavir-boosted protease inhibitor containing HAART and both required maintenance hydrocortisone therapy following diagnosis. This highlights the need for radiologists and clinicians practicing these injections to be aware of this complication, to elicit an accurate drug history, and to take adequate measures to minimize these adverse effects.

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References

  1. Novir (®) Tablets Summary of Product Characteristics, Abbott Laboratories Ltd, April 2010. http://www.hiv-druginteractions.org/data/FactSheetImages/FactSheet_DrugID_126.pdf Accessed 03/04/2012

  2. Derendorf H, Möllmann H, Grüner A, et al. Pharmacokinetics and pharmacodynamics of glucocorticoid suspensions after intra-articular administration. Clin Pharmacol Ther. 1986;39(3):313–7.

    Article  PubMed  CAS  Google Scholar 

  3. Ramanathan R, Pau AK, Busse KH, Zemskova M, Nieman L, Kwan R, Hammer JH, Mican JM, Maldarelli F. Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir. Clin Infect Dis. 2008;47:e97–9.

    Article  PubMed  CAS  Google Scholar 

  4. Dort K, Padia S, Wispelwey B, Moore CC. Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report. AIDS Res Ther. 2009;6:10.

    Article  PubMed  Google Scholar 

  5. Danaher PJ, Salsbury TL, Delmar JA. Metabolic derangement after injection of triamcinolone into the hip of an HIV-infected patient receiving ritonavir. Orthopedics. 2009;32(6):450.

    Article  PubMed  Google Scholar 

  6. St Germain RM, Yigit S, Wells L, Girotto JE, Salazar JC. Cushing syndrome and severe adrenal suppression caused by fluticasone and protease inhibitor combination in an HIV-infected adolescent. AIDS Patient Care STDS. 2007;21:373–7.

    Article  PubMed  Google Scholar 

  7. Albert NE, Kazi S, Santoro J, Dougherty R. Ritonavir and epidural triamcinolone as a cause of iatrogenic Cushing’s syndrome. Am J Med Sci. 2012;344:72–4.

    Article  PubMed  Google Scholar 

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Acknowledgments

We thank Neal Marshall for assistance in the preparation of this article for publication.

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The authors declare that they have no conflicts of interest.

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Correspondence to M. Maviki.

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Maviki, M., Cowley, P. & Marmery, H. Injecting epidural and intra-articular triamcinolone in HIV-positive patients on ritonavir: beware of iatrogenic Cushing’s syndrome. Skeletal Radiol 42, 313–315 (2013). https://doi.org/10.1007/s00256-012-1539-6

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  • DOI: https://doi.org/10.1007/s00256-012-1539-6

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