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Effects of Lactobacillus salivarius, Lactobacillus reuteri, and Pediococcus acidilactici on the nematode Caenorhabditis elegans include possible antitumor activity

  • Applied Microbial and Cell Physiology
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Abstract

This study examined the effects of three lactic acid bacteria (LAB) strains on the nematode Caenorhabditis elegans. Lactobacillus salivarius, Lactobacillus reuteri, and Pediococcus acidilactici were found to inhibit the development and growth of the worm. Compared to Escherichia coli used as the control, L. reuteri and P. acidilactici reduced the lifespan of wild-type and short-lived daf-16 worms. On the contrary, L. salivarius extended the lifespan of daf-16 worms when used live, but reduced it as UV-killed bacteria. The three LAB induced the expression of genes involved in pathogen response and inhibited the growth of tumor-like germ cells, without affecting DAF16 localization or increasing corpse cells. Our results suggest the possible use of C. elegans as a model for studying the antitumor attributes of LAB. The negative effects of these LAB strains on the nematode also indicate their potential use against parasitic nematodes.

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Authors and Affiliations

  1. Center of Basic Research II, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou, 11527, Athens, Greece

    Michael K. Fasseas & Popi Syntichaki

  2. Department of Agricultural Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855, Athens, Greece

    Costas Fasseas

  3. Department of Nutritional Physiology and Feeding, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, 75 Iera Odos, 11855, Athens, Greece

    Konstantinos C. Mountzouris

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  1. Michael K. Fasseas
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  2. Costas Fasseas
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  3. Konstantinos C. Mountzouris
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  4. Popi Syntichaki
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Correspondence to Michael K. Fasseas.

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Fasseas, M.K., Fasseas, C., Mountzouris, K.C. et al. Effects of Lactobacillus salivarius, Lactobacillus reuteri, and Pediococcus acidilactici on the nematode Caenorhabditis elegans include possible antitumor activity. Appl Microbiol Biotechnol 97, 2109–2118 (2013). https://doi.org/10.1007/s00253-012-4357-9

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