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John C. P. Williams of Williams-Beuren syndrome

  • Historical Perspective
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Abstract

John C.P. Williams of New Zealand, whose name is associated with Williams-Beuren syndrome, spent his known professional career primarily in cardiovascular research. His disappearance in the mid-1970s and his later life remain a mystery.

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References

  1. Berdon WE, Clarkson P, Teele RL (2010) Williams-Beuren syndrome: Historical aspects. Pediatr Radiol 41, doi:10.1007/s00247-010-1908-z

  2. King M (2000) Wrestling with the angel: a life of Janet Frame. Penguin Books, New Zealand, p 583

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Acknowledgements

We thank Ms. Nicole Babcock, archivist at the Mayo Clinic; E. Andrew Wood of Rochester, MN, for Fig. 1; Dr. Sally Page (Dept. of Physiology, University College London); the numerous colleagues and friends of Dr. Williams whom we interviewed, and Thomas Morgan, nephew of Dr. J.C.P. Williams, for their help.

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Authors and Affiliations

  1. Developmental & Cell Biology, School of Biological Sciences, University of California, Irvine, Irvine, CA, USA

    Howard M. Lenhoff

  2. Department of Radiology, Starship Children’s Hospital, Auckland Medical School, Auckland, New Zealand

    Rita L. Teele

  3. Department of Radiology, Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Rita L. Teele

  4. Green Lane Paediatric and Congenital Cardiac Service, Starship Children’s Hospital, Auckland, New Zealand

    Patricia M. Clarkson

  5. Department of Radiology, Children’s Hospital of New York, New York, NY, USA

    Walter E. Berdon

Authors
  1. Howard M. Lenhoff
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  2. Rita L. Teele
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  3. Patricia M. Clarkson
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  4. Walter E. Berdon
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Corresponding author

Correspondence to Rita L. Teele.

Appendix Curriculum Vitae

Appendix Curriculum Vitae

Name: John Cyprian Phipps Williams

Date and place of Birth: November 16, 1922, Wellington, New Zealand

Academic Institutions attended, degrees awarded, and year of award:

  • Bachelor of Science, 1945. Victoria College, University of New Zealand

  • Bachelor of Arts, 1947. Victoria College, University of New Zealand

  • Bachelor of Medicine, Bachelor of Surgery, 1953. Otago Medical School (Dunedin), University of New Zealand

Postgraduate Diploma: Member of the Royal Australasian College of Physicians (MRACP) Fellow (1978)

Positions held (position, place, years):

  • 1954–1955 House surgeon (Intern), Auckland Hospital, NZ

  • 1955 Thames Hospital, NZ

  • 1956–1962 Auckland and Green Lane Hospitals, Auckland, NZ. Appointed cardiology consultant Green Lane Hospital 1963

  • Oct. 1, 1962, to Sept. 30, 1965. N.I.H. Postdoctoral Fellow in Cardiovascular Physiology in Laboratory of Professor E.A. Wood, Mayo Clinic, Rochester, MN, USA

  • Oct. 1, 1965, to Sept. 30, 1966. Consultant with Professor E.A. Wood, Mayo Clinic, Rochester, MN, USA

  • Oct. 1, 1966, to Oct. 1, 1968. Laboratory of Professor A.F. Huxley at University College London, UK; also associated with Mayo Clinic through 1968

Position formally offered and declined:

  • 1972. Agreed to accept job offered by Dr. Homer Warner at Latter Day Saints Hospital, Salt Lake City, but later changed his mind.

Honor: Plunket Oratory Medal from Victoria University, NZ (1944)

Publications

  1. 1.

    Lowe JB, Williams JCP, Robb D, Cole D (1959) Congenital diverticulum of the left ventricle. Brit Heart J 21:101–106

  2. 2.

    Williams JCP, Barratt-Boyes BG (1959) Atrial septal defect: the results of repair using the atrial well. NZ Med J 58:279–287

  3. 3.

    Barratt-Boyes B, Lowe JB, Cole DS, Watt WJ, Williams JCP (1960) Initial experience with extracorporeal circulation in intracardiac surgery. Brit Med J 2:1826–1831

  4. 4.

    Williams JCP, Barratt-Boyes BG, Lowe JB (1961) Supravalvular aortic stenosis. Circulation 24:1311–1318

  5. 5.

    North JDK, Williams JCP, Howie RN (1961) Severe hypertension treated with ganglion-blocking drugs in a general hospital. Brit Med J 1:1426–1429

  6. 6.

    Williams JCP, Barratt-Boyes BG, Lowe JB (1963) Underdeveloped right ventricle and pulmonary stenosis. Am J Cardiol 11:458–468

  7. 7.

    Williams JCP, O’Donovan TP, Wood EH (1966) A method for the calculation of areas under indicator-dilution curves. J Appl Physiol 21:695–699

  8. 8.

    Williams JCP, O’Donovan TP, Cronin L, Wood EH (1967) Influence of sequence of atrial and ventricular systole on closure of mitral valve. J Appl Physiol 22:786–792

  9. 9.

    Boyde A, Williams JCP (1968) Proceedings of the Physiological Society, 22–23 March 1968, University College Meeting: Surface morphology of frog striated muscle as prepared for and examined in the scanning electron microscope. J. Physiol (Suppl) 197:10P–11P

  10. 10.

    Williams JC, Vandenberg RA, Sturm RE, Wood EH (1968) Presystolic atriogenic mitral reflux developed at abnormally long PR intervals. Cardiovasc Res 2:271–277

  11. 11.

    Williams JC, Vandenberg RA, O’Donovan TP, Sturm RE, Wood EH (1968) Roentgen video densitometer study of mitral valve closure during atrial fibrillation. J Appl Physiol 24:217–224

  12. 12.

    Williams JC, O’Donovan PB, Vandenberg RA, Sturm RE, Wood EH (1968). Atriogenic mitral valve reflux: diastolic mitral incompetence following isolated atrial systoles. Circ Res 22:19–27

  13. 13.

    Williams JCP, Sturm RE, Tsakiris AG, Wood EH (1968). Biplane videoangiography. J Appl Physiol 24:724–727

  14. 14.

    Williams JCP, Lambert EH, Titus JL (1969) Use of intracardiac AV nodal potentials in producing complete heart block in dogs. J Appl Physiol 27:740–744

  15. 15.

    Vandenberg, RA, Williams JCP, Sturm RE, Wood EH (1969) Effect of ventricular extrasystoles on closure of mitral valve. Circulation 39:197–204

  16. 16.

    Vandenberg RA, Williams JCP, Sturm RE, Wood EH (1971) Effect of varying ventricular function by extrasystolic potentiation on closure of the mitral valve (Extrasystolic potentiation of ventricular contraction effect on dog mitral valve function, using roentgen videodensitometry). Am J Cardiol 28:43–53

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Lenhoff, H.M., Teele, R.L., Clarkson, P.M. et al. John C. P. Williams of Williams-Beuren syndrome. Pediatr Radiol 41, 267–269 (2011). https://doi.org/10.1007/s00247-010-1909-y

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