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Focal nodular hyperplasia in children, adolescents, and young adults

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Abstract

Background

Focal nodular hyperplasia (FNH) is a benign hepatic tumor that is rare in children. In order to understand whether there are differences in the etiology or appearance of FNH in children, we analyzed the clinical information and imaging of pathologically proven cases.

Materials and methods

A pathology database was used to identify all cases of FNH diagnosed at our institution. Each patient’s imaging was evaluated for the characteristics of FNH lesions. Clinical information was obtained on each patient.

Results

Thirteen patients with FNH were identified (7 male/6 female, mean age 14.3 years, range 1–27 years). Seven patients (5 male/2 female) had a remote history of childhood malignancy. The time interval between the diagnoses of malignancy and FNH ranged from 9 to 27 years (mean 14.4 years). On imaging, all seven cancer survivors had multiple liver lesions. In the remaining six patients (2 male/4 female), there was no history of malignancy and all but one of these patients had a solitary FNH.

Conclusion

Half of the patients with FNH in this study were long-term cancer survivors and each of these patients had multiple masses. Recognizing the features of FNH will aid in diagnosis and appropriate management.

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Authors and Affiliations

  1. Department of Radiology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave., ML# 5031, Cincinnati, OH, 45229, USA

    Alexander J. Towbin

  2. Department of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Guangju G. Luo, Hong Yin & Jun Q. Mo

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  1. Alexander J. Towbin
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  2. Guangju G. Luo
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  3. Hong Yin
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  4. Jun Q. Mo
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Correspondence to Alexander J. Towbin.

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Towbin, A.J., Luo, G.G., Yin, H. et al. Focal nodular hyperplasia in children, adolescents, and young adults. Pediatr Radiol 41, 341–349 (2011). https://doi.org/10.1007/s00247-010-1839-8

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  • DOI: https://doi.org/10.1007/s00247-010-1839-8

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